2-(4-Chlorobenzyl)1H Benzimidazole

2-% (4-chlorobenzyl) -1H-benzimidazole is one of the organic compounds. Its main uses are in many fields.
In the field of medicinal chemistry, it is often a key intermediate for drug research and development. Due to its unique structure, it can be chemically modified in a variety of ways to create drug molecules with specific biological activities. For example, some drugs with antibacterial, antiviral or antitumor activities may be an indispensable part of the synthesis pathway. By fine modification of its structure, it can regulate the interaction between drugs and biological targets, thereby improving the efficacy and selectivity of drugs.
In the field of materials science, it also shows potential value. It can participate in the preparation of functional materials, such as fluorescent materials. Due to its structural properties, it may endow materials with unique optical properties, and may play an important role in the manufacture of fluorescent probes, Light Emitting Diodes and other devices, providing new ideas and approaches for the design and optimization of materials.
In pesticide chemistry, it may be used as a starting material for pesticide creation. After chemical transformation, pesticide ingredients with high inhibitory effect on specific pests or pathogens are derived, which helps to control agricultural pests and diseases and ensure the yield and quality of crops.
Overall, 2% (4-chlorobenzyl) -1H-benzimidazole has important uses in many fields such as medicine, materials and pesticides, providing an important material basis and research direction for the research and development of related fields.

To prepare 2 - (4 -chlorobenzyl) -1H -benzimidazole, there are three methods. First, 4-chlorobenzyl chloride and o-phenylenediamine are used as starting materials, and in a suitable solvent, such as ethanol or dimethylformamide, a base such as potassium carbonate is added, and refluxed. In this case, the action of the base is to bind the acid, so that the reaction proceeds to the formation of the product. After the reaction is completed, the crude product can be obtained by cooling, filtering, washing, and drying, and then purified by recrystallization. Second, using 4-chlorobenzaldehyde and o-phenylenediamine as raw materials, the Schiff base is first condensed, and then the target is cyclized in the presence of a suitable catalyst such as acetic acid or p-toluenes The reaction is usually carried out by heating in an organic solvent such as toluene, and the water is removed by a water separator to promote the complete reaction. At the end of the reaction, it is purified by reduced pressure distillation, column chromatography, etc. Third, the o-phenylenediamine is first reacted with formic acid or formate to form benzimidazole, followed by N-alkylation with 4-chlorobenzyl halogen. The alkylation reaction is carried out in the presence of a base and is carried out in a polar solvent such as acetonitrile. After the reaction is completed, the product is obtained by extraction, concentration, crystallization and other processes. Each method has its own advantages and disadvantages. The first method is common in raw materials and easy to operate. The secondary method steps are slightly complicated, but the yield may be higher. The conditions of the three methods are mild, so it is In actual synthesis, factors such as raw material availability, cost, and yield should be weighed and selected.

2-% 284 - Chlorobenzyl% 291H - Benzimidazole, the Chinese name is often 2 - (4 - chlorobenzyl) -1H - benzimidazole. This substance has the following physical and chemical properties:
In appearance, it is mostly white to light yellow crystalline powder at room temperature. This morphology is conducive to identification and distinction, and the powdered substance can provide a large specific surface area in the reaction, which is conducive to the progress of chemical reactions.
In terms of melting point, it is about 170 - 175 ° C. Melting point is an important indicator for identifying the compound. By measuring the melting point, its purity and authenticity can be preliminarily determined. If the measured melting point is close to this value, it indicates that its purity is high; if the deviation is large, it may contain impurities. In terms of solubility, it is slightly soluble in water and soluble in common organic solvents such as ethanol, dichloromethane, etc. This solubility characteristic determines its application in different solvent systems. For example, in organic synthesis reactions, ethanol or dichloromethane can be selected as the reaction solvent, so that the compound can be fully dissolved and participate in the reaction; in aqueous systems, because of its slight solubility, special means need to be considered to promote its dispersion or reaction. In terms of stability, under conventional storage conditions, in a dry and cool place, the properties are relatively stable. However, it is necessary to avoid contact with strong oxidants, strong acids, strong bases, etc., because the benzimidazole ring and chlorobenzyl group in the structure may react with these substances, resulting in structural changes, which in turn affect its performance and use. In case of strong oxidants, oxidation reactions may be initiated, causing oxidation of nitrogen atoms or chlorobenzyl groups on the benzimidazole ring; in case of strong acids or bases, reactions such as ring opening of the benzimidazole ring may be caused.

Today I have a question about the price of 2- (4-chlorobenzyl) -1H-benzimidazole in the market. This is a chemical product. In "Tiangong Kaiwu", the market price of this specific product is not recorded in detail. When "Tiangong Kaiwu" was written, most chemical products were traditional products, such as hardware, pottery, paper, ink, etc. This 2- (4-chlorobenzyl) -1H-benzimidazole, or did not exist at that time, or was not valued by the world.
Today is different from the past. Chemistry has developed rapidly, and the price of this product is not a fixed number. Its price is affected by many factors. First, its purity is crucial. If the purity is high, it is suitable for high-end scientific research, pharmaceutical manufacturing, etc., and the price must be high; if the purity is low, it is only for ordinary experiments or crude chemicals, and the price may be slightly cheaper.
Furthermore, the situation of supply and demand also affects its price. If there are many people in the market who want it, but there are few people who produce it, the price will rise; on the contrary, if the supply exceeds demand, the price will drop.
The cost of production is also the key. The price of raw materials, the simplicity of the production process, and the consumption of manpower and material resources are all related to its price. If raw materials are scarce and difficult to harvest, or the production process is complicated, high-tech equipment and professional personnel are required, and the price must be high. < Br >
To know the exact price of this product, consult chemical market merchants, chemical reagent suppliers, or refer to the chemical product price information platform to obtain the actual price.

2-% 284-Chlorobenzyl% 29-1H-benzimidazole, its safety and toxicity are related to human life and cannot be ignored. This substance may be used in industry or scientific research, but its impact on the human body and the environment needs to be investigated in detail.
To consider its safety, if it is not in close contact with the human body in ordinary environments, and it is properly stored, or it will not cause serious harm. However, if it is accidentally inhaled, it may cause respiratory discomfort, such as cough and asthma. And if it touches the skin, or causes skin allergies, erythema and itching can be seen. As for the eyes, it will hurt the eyes, pain, redness and swelling, and even damage the vision.
As for its toxicity, after experimental investigation, it is on the animal body, or the appearance of organ damage. If ingested for a long time, the function of the liver and kidneys may be affected, metabolic disorders, and toxin accumulation may be affected. And there is a risk of mutagenesis, interfering with the genetic material of the organism, causing genetic mutations, and having adverse consequences for the reproduction of future generations. In the environment, if this substance flows into water sources, soils, or harms aquatic organisms and plants, it will disrupt the ecological balance.
Therefore, when using 2% 284-chlorobenzyl% 29-1H-benzimidazole, safety procedures should be strictly followed and protective measures should be taken to ensure personal safety and environmental safety.