2-(4-bromophenyl)-1-methyl-1H-imidazole

2-%284-%E6%BA%B4%E8%8B%AF%E5%9F%BA%29-1-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91, this is a specific compound expression in the field of organic chemistry. Among them, 2- (4-bromophenyl) -1-methyl-1H-pyrazole has a wide range of main uses.
In the field of medicinal chemistry, this compound is often a key intermediate. Due to its unique chemical structure, it can be linked to other groups through various chemical reactions to construct drug molecules with specific biological activities. In the development of many antibacterial and anti-inflammatory drugs, it is used as a starting material, and the molecular structure is modified and optimized through carefully designed reaction routes to achieve ideal pharmacological properties.
In the field of materials science, 2- (4-bromophenyl) -1-methyl-1H-pyrazole also has important applications. It can be involved in the preparation of functional organic materials, such as photoelectric materials. Due to its structure endowing molecules with specific electronic properties, it may play a role in regulating charge transport and improving luminous efficiency in devices such as organic Light Emitting Diodes (OLEDs) or organic solar cells, providing a key foundation for the creation of new high-performance materials.
In organic synthetic chemistry, it is a commonly used synthetic building block. With its activity check point, chemists build more complex organic molecular structures through nucleophilic substitution, coupling and other reactions, help the synthesis and methodological development of novel organic compounds, and promote the continuous progress of organic chemistry.

To prepare 2 - (4 -cyanobenzyl) - 1 -methyl - 1H -pyrazole, there are many ways to synthesize it.
First, we can start from nitrogen-containing heterocyclic compounds. Using suitable pyrazole derivatives as raw materials, first modify their specific positions. If the methyl group is introduced before the first position of the pyrazole ring, a methylating agent such as iodomethane and the corresponding pyrazole can be selected. Under basic conditions, a base such as potassium carbonate, in a suitable solvent such as N, N-dimethylformamide (DMF), the heating reaction prompts the methyl group to replace the hydrogen on the pyrazole ring to generate 1-methyl-1H-pyrazole derivatives. Then, (4-cyanobenzyl) is introduced at the second position. 1-Methyl-1H-pyrazole can be reacted with 4-cyanobenzyl halide, such as 4-cyanobenzyl chloride, in an alkaline environment, such as sodium hydride, in an anhydrous tetrahydrofuran solvent, and the nucleophilic substitution process can be used to achieve the synthesis of 2- (4-cyanobenzyl) -1-methyl-1H-pyrazole.
Second, the strategy of constructing pyrazole rings can be used. Pyrazole rings are constructed by reacting 1,3-dicarbonyl compounds with nitrogen-containing reagents. For example, acetylacetone is reacted with methylamine first to generate the corresponding enamide intermediate, and then cyanobenzaldehyde is cyclized with acidic catalysis, such as p-toluenesulfonic acid, to form a pyrazole ring. At the same time, cyanobenzyl and methyl are introduced at a suitable position. After multi-step reaction, the target product 2- (4-cyanobenzyl) -1-methyl-1H-pyrazole can also be obtained.
Third, the coupling reaction catalyzed by transition metals can be used. Using halogenated pyrazole derivatives, such as 2-halo-1-methyl-1H-pyrazole with 4-cyanobenzylboronic acid or its esters, under the catalysis of transition metal catalysts such as palladium, such as tetra (triphenylphosphine) palladium, under basic conditions, such as cesium carbonate basic environment, in a suitable solvent such as dioxane, through Suzuki coupling reaction, 2- (4-cyanobenzyl) -1-methyl-1H-pyrazole can be efficiently synthesized. Each method has its own advantages and disadvantages, and the selection needs to be comprehensively considered according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the cost.

2-%284-%E6%BA%B4%E8%8B%AF%E5%9F%BA%29-1-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91%E7%9A%84%E5%85%B7%E4%BD%93%E5%90%8D%E7%A7%B0%E5%BA%94%E6%98%AF2 - (4 - hydroxybenzyl) -1 - methyl - 1H - pyrazole, which has the following physical properties:
appearance, often presented as white to off-white crystalline powder, texture is more fine uniform, observed in natural light, the powder surface has a certain luster.
solubility, which has a certain solubility in organic solvents such as ethanol, acetone. In ethanol, with the increase of temperature, the solubility will increase, and under heating conditions, it can be better dissolved to form a clear solution; in water, the solubility is relatively poor, and it is almost insoluble at room temperature, mainly due to its molecular structure contains more hydrophobic groups, and the interaction force between water molecules is weak.
The melting point is about [specific melting point value]. When heated to this temperature, the substance will gradually change from solid to liquid, and the phase state will change. The determination of this melting point is of great significance for identification and purity judgment. If the purity of the substance is high, the melting point range is narrow, otherwise the melting point range may be wider. < Br >
In terms of stability, under normal temperature, pressure and dark conditions, the substance has good stability, chemical properties are relatively inactive, and can be stored for a long time without obvious deterioration. However, in strong acid and alkali environments, its structure may be damaged and chemical reactions occur, resulting in changes in its physical and chemical properties.
The density is [specific density value]. This physical property determines its accumulation state and space occupation under specific conditions, and has certain reference value for material measurement and storage in chemical production.

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This is a problem related to organic compounds, and I will describe its chemical properties in detail.
2- (4-bromobenzyl) -1-methyl-1H-pyrazole This compound has a certain stability of the pyrazole ring. The nitrogen atom in the pyrazole ring is rich in electrons and can participate in a variety of chemical reactions, such as nucleophilic substitution reactions. Because there are lone pairs of electrons on the nitrogen atom, it can be used as a nucleophilic agent to attack the electrophilic reagent.
Bromobenzyl moiety, bromine atom is a good leaving group. Under appropriate conditions, nucleophilic substitution reactions are prone to occur. For example, when reacting with nucleophilic reagents such as sodium alcohol and amine, bromine atoms can be replaced by corresponding groups to form new organic compounds. In this process, the control of reaction conditions is very critical, and factors such as temperature and solvent will affect the reaction rate and product selectivity.
methyl is attached to the pyrazole ring, which has an impact on the electron cloud distribution of the compound. Methyl as the power supply group can increase the electron cloud density of the pyrazole ring, which in turn affects its reactivity, making it more likely to react in the electrophilic substitution reaction, and the reaction check point may be affected by the methyl localization effect.
1H-pyrazole part of the hydrogen atom is acidic under certain conditions. In case of a strong base, the hydrogen atom can be taken away to form a corresponding negative ion, which can be used as a nucleophilic reagent to participate in subsequent reactions.
This compound has important application value in the field of organic synthesis, and can be designed and carried out through its different chemical properties to prepare complex organic compounds, providing an important material basis for the development of medicinal chemistry, materials science and many other fields.

I think what you are asking is about "what is the price range of 2 - (4 -cyanobenzyl) -1 -methyl-1H -indole in the market". However, this is a chemical substance, and its price often varies due to many factors.
First, the purity has a great impact. If the purity is very high and almost perfect, the price will be high; if the purity is slightly lower, the price will be relatively low. For example, refined gold and miscellaneous gold, the price is different.
Second, the situation of supply and demand is also critical. If the market demand is strong and the output is limited, the so-called "rare is expensive", the price will be high; conversely, if the supply exceeds the demand, the price will easily fall.
Third, the source channels are different. Those carefully prepared by famous factories are of reliable quality, and the price may not be low; if the source is ordinary, the price may be different.
Today, such chemicals are in the market, and the price range fluctuates greatly. Ordinary purity, or tens of yuan per gram; if the purity is high, designed for specific high-end uses, the price per gram can reach hundreds of yuan, or even more.
However, the market is changing, and the price is also like a current wave, changing from time to time. To know the exact price, when you visit the chemical market in person, or consult merchants and experts in the industry, you can get an accurate number.