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What is the chemical structure of 2- {[4- (3-methoxypropoxy) -3-methylpyridin-2-yl] methylthio} -1H-benzimidazole?
First of all, it involves "2 - {[4 - (3 - methoxyethoxy) - 3 - methylpyridine - 2 - yl] formyl} - 1H - benzimidazole", which is one of the organic compounds. Looking at its structure, benzimidazole is the core skeleton. 1H - benzimidazole, which is a nitrogen-containing heterocyclic structure, is formed by fusing a benzene ring with an imidazole ring.
And on top of this basic structure, there is a complex substituent. "{[4 - (3-methoxyethoxy) -3 -methylpyridine-2-yl] formyl}", pyridine is also a nitrogen-containing heterocyclic ring, with methyl substitution at the 3-position and ether chain structure such as 3-methoxyethoxy at the 4-position. The 2-position of this pyridine ring is connected to benzimidazole through formyl groups.
Such a structure makes this compound have unique chemical properties and potential biological activities. The ether chain of methoxy ethoxy can affect the balance of lipophilicity and water solubility, while the nitrogen atom on the pyridine ring and benzimidazole ring can participate in a variety of chemical reactions or interact with biological targets.
Although its structure is complex, it can also be seen through such twisting and stripping. The beauty of chemistry lies in this. Complex structures contain endless mysteries, waiting for our generation to explore.
What are the physical properties of 2- {[4- (3-methoxypropoxy) -3-methylpyridin-2-yl] methylthio} -1H-benzimidazole?
2-% {[ (4- (3-methoxyethoxy) -3-methoxypropyl-2-yl) ] methylcarboxyl} -1H-indolo-pyrrole compounds possess several unique physical properties. The appearance of this compound is often specific, mostly crystalline or powdery, and the color may be white to yellowish, which is related to its internal structure and electronic transition characteristics.
From a solubility point of view, the substance exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide, which is due to the interaction between molecules and solvents, including van der Waals forces, hydrogen bonds, etc., while it has poor solubility in water because its molecular polarity does not match water.
In terms of melting point, experimentally determined, it has a relatively high melting point, which indicates that the intermolecular force is strong, and more energy is required to overcome the lattice energy to melt the substance. This is due to the interaction between molecules such as hydrogen bonds 、π - π stacking, which enhances the stability of the crystal structure.
Its density is affected by the molecular composition and stacking mode, which is relatively moderate, reflecting the relationship between molecular mass and occupied space.
In addition, the compound has a certain stability and can maintain its own structure under conventional conditions, but under extreme conditions such as high temperature, strong acid and alkali, structural changes or reactions may occur, which is related to the activity of functional groups in the molecule.
What are the main uses of 2- {[4- (3-methoxypropoxy) -3-methylpyridin-2-yl] methylthio} -1H-benzimidazole?
2-%7B%5B4-%283-%E7%94%B2%E6%B0%A7%E5%9F%BA%E4%B8%99%E6%B0%A7%E5%9F%BA%29-3-%E7%94%B2%E5%9F%BA%E5%90%A1%E5%95%B6-2-%E5%9F%BA%5D%E7%94%B2%E7%A1%AB%E5%9F%BA%7D-1H-%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91, this is the expression of specific compounds in organic chemistry. Its main uses are quite extensive and of great significance in the field of organic synthesis.
In the field of pharmaceutical research and development, it can act as a key intermediate. Through a series of chemical reactions, it can build molecular structures with specific biological activities to help synthesize new drugs for the treatment and prevention of diseases. For example, in the synthesis of some anti-cancer drugs and anti-infective drugs, it may participate in key steps and affect the construction and activity of drug molecules.
In the field of materials science, it can be used as a synthetic raw material for functional materials. By polymerizing or reacting with other substances, materials with special properties are generated, such as materials with good electrical conductivity, optical properties or mechanical properties, which are used in electronic devices, optical instruments and other fields.
In the fragrance industry, it may also play a role. Due to its unique chemical structure, through appropriate modification and transformation, compounds with specific aromas can be produced, which can be used to prepare various flavors and fragrances, add the aroma characteristics of products, and are used in perfumes, food additives and other industries.
At the same time, it is also an important research object in the basic research of organic chemistry. Through in-depth investigation of its reaction mechanism and chemical properties, scientists deepen their understanding and understanding of the laws of organic chemical reactions, providing theoretical support for the development of organic synthesis methodologies.
What are the preparation methods of 2- {[4- (3-methoxypropoxy) -3-methylpyridin-2-yl] methylthio} -1H-benzimidazole?
To prepare 2 - {[4- (3-methoxyethoxy) -3-methylpyridine-2-yl] methanesulfonyl} -1H-indazole, the method is as follows:
First as the selection and preparation of raw materials. Select appropriate starting materials, such as pyridine derivatives with specific substituents and compounds related to the parent structure of indazole, to ensure the purity and quality of the raw materials. This is the basis for the smooth progress of the reaction.
Then the reaction is done. The goal can be achieved by multi-step organic reaction. First, the specific functional group in the pyridine derivative is reacted with the reagent containing methoxyethoxy group under suitable conditions, such as in the catalysis of alkali, the specific temperature and the solvent environment, to promote the substitution reaction to obtain the pyridine intermediate containing 3-methoxyethoxy group.
Then, the intermediate is further modified. The specific position on the pyridine ring is methylated to introduce methyl groups. This step also requires attention to the control of the reaction conditions, the proportion of reactants, the reaction temperature and time, etc., to ensure the selectivity and yield of the reaction.
Furthermore, the methanesulfonyl moiety is prepared. Methanesulfonyl chloride is obtained by oxidation of methanethiol and other raw materials, and then the methanesulfonyl chloride is reacted with a specific substituted pyridine intermediate in the presence of a base, and the methanesulfonyl group is introduced into the designated position of the pyridine ring to obtain the key intermediate.
Finally, the key intermediate is reacted with the indazole parent structure under suitable conditions, or through mechanisms such as nucleophilic substitution, the target product 2 - {[4- (3-methoxyethoxy) -3 -methylpyridine-2-yl] methanesulfonyl} -1H -indazole is constructed. After the reaction is completed, the high-purity product can be obtained by means of separation and purification, such as column chromatography, recrystallization, etc.
The whole preparation process requires fine control of the reaction conditions at each step, close monitoring of the reaction process, and accurate characterization of the products at each step to obtain the target compound efficiently and with high quality.
What are the market prospects for 2- {[4- (3-methoxypropoxy) -3-methylpyridin-2-yl] methylthio} -1H-benzimidazole?
There are now 2 - {[4 - (3 - methoxyethoxy) -3 - methylpyridine - 2 - yl] formyl} -1H - indazole, and its market prospects are related to many parties. Looking at this compound, its structure contains unique groups, methoxyethoxy, methylpyridine and other endowed properties. In the field of medicine, or because of its structural characteristics, it has biological activity and can interact with specific targets, providing opportunities for the development of new drugs. If it can accurately fit disease-related receptors or enzymes, it is expected to become a drug for the treatment of specific diseases, and the prospect is promising. In the chemical industry, it can be used as a synthetic raw material or intermediate to build more complex compounds with its structure and expand the diversity of chemical products.
However, its market prospects also face challenges. Developing new drugs requires a long process, from basic research to clinical trials, which consumes huge resources and time, and has a high risk of failure. In chemical applications, the synthesis process may have problems, and it is necessary to optimize conditions, improve yield and purity, otherwise the cost will be difficult to control and affect market competitiveness.
Overall, 2 - {[4 - (3 - methoxyethoxy) -3 - methylpyridine - 2 - yl] formyl} -1H - indazole has addressable market value, but to achieve it, many obstacles need to be overcome in R & D and production. If properly solved, it will emerge in the pharmaceutical and chemical markets.