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What is the chemical structure of 2- [{4- (3-Methoxypropoxy) -3-methyl pyridine-2-yl} methylthio] -1H-benzimidazole?
Eh! This is an organic chemical substance, called 2 - [ { 4 - (3 - methoxypropoxy) - 3 - methylpyridine - 2 - yl} methionyl] - 1H - benzimidazole. To know its chemical structure, when disassembling and viewing from various parts.
First of all, the core of benzimidazole, which is a fused heterocyclic structure, is composed of a benzene ring and an imidazole ring. The imidazole ring has a dinitrogen atom, which is stable in structure and has unique chemical properties. It is common in many drugs and bioactive molecules.
Review the side chain part. Among them, the pyridine-2-yl group, the pyridine ring is a nitrogen-containing hexagonal aromatic ring, which has aromatic properties. The modification of 3-methyl group introduces methyl groups to the pyridine ring, which affects its electron cloud distribution and steric resistance. The structure of 4 - (3-methoxypropoxy), the methoxy group is connected to the propoxy group, and this long chain structure imparts specific hydrophilicity and flexibility to the molecule, which can affect its interaction with the receptor.
As for {4- (3-methoxypropoxy) -3-methylpyridine-2-yl} methylthio, methylthio is a sulfur atom connected to a methyl group, which is connected to a pyridine-2-group, and is reconnected to a benzimidazole nucleus. Sulfur atoms can provide lone pair electrons, participate in intermolecular interactions, and affect the chemical and physical properties of the molecule as a whole.
Overall, the chemical structure of this compound is delicate and complex, and the interaction of various parts jointly determines its unique chemical, physical and biological activities.
What are the main uses of 2- [{4- (3-Methoxypropoxy) -3-methyl pyridine-2-yl} methylthio] -1H-benzimidazole?
2-% 5B% 7B4-% 283-methoxypropoxy% 29-3-methylpyridine-2-yl% 7D-methylthio% 5D-1H-benzimidazole This substance has a wide range of uses. In the field of medicine, it is often the key raw material for the creation of new anti-ulcer drugs. Because it can effectively inhibit gastric acid secretion and has a good protective effect on the gastric mucosa, it plays an important role in the development of therapeutic drugs for gastric ulcer, duodenal ulcer and other diseases.
In the chemical industry, it can be used as an intermediate for the synthesis of special functional materials. Through a series of chemical reactions, it can be converted into polymer materials with unique properties. For example, in the production of some plastic products with high requirements for stability and corrosion resistance, the materials synthesized by this substance are very useful.
In terms of scientific research and exploration, it is also an important research object. Scientists carry out various experiments around it, hoping to further clarify its chemical properties and reaction mechanism, and then develop more related new uses and new applications, providing a more solid theoretical and practical foundation for the development of medicine, chemical industry and many other fields.
What is the production method of 2- [{4- (3-Methoxypropoxy) -3-methyl pyridine-2-yl} methylthio] -1H-benzimidazole?
To prepare 2 - [ { 4 - (3 - methoxypropoxy) - 3 - methylpyridine - 2 - yl} methionyl] - 1H - benzimidazole, the method is as follows:
first take suitable raw materials, benzimidazole-based, which requires the introduction of a specific sulfur-containing side chain 2. Benzimidazole can be reacted with halogenated hydrocarbon derivatives. This halogenated hydrocarbon must be connected to the {4- (3-methoxypropoxy) -3-methylpyridine-2-yl} methionyl structure at a specific position.
When reacting, choose a suitable solvent, such as a polar organic solvent, such as dimethylformamide, etc., to facilitate the dissolution of the reactants and the reaction. At the same time, add an appropriate amount of base, such as potassium carbonate, etc., the base can promote the nucleophilic substitution reaction.
Warm up to an appropriate temperature and maintain it for a certain period of time to make the reaction sufficient. This process requires close monitoring of the reaction process. TLC and other means can be used to cool the reaction system until the reaction reaches the desired level.
After that, after post-treatment steps, such as extraction with suitable solvents to remove impurities, and then refined by column chromatography or recrystallization, to obtain a pure 2 - [ { 4 - (3 - methoxypropoxy) - 3 - methylpyridine - 2 - yl} methionyl] - 1H - benzimidazole product. The whole process requires attention to the precise control of reaction conditions and the specifications of each step to obtain the product with ideal yield and purity.
What are the physicochemical properties of 2- [{4- (3-Methoxypropoxy) -3-methyl pyridine-2-yl} methylthio] -1H-benzimidazole?
2-% 5B% 7B4-% 283-methoxypropoxy% 29-3-methylpyridine-2-yl% 7D-methylthio% 5D-1H-benzimidazole This product has many physical and chemical properties. Its appearance is often white to off-white crystalline powder, which is quite stable under normal conditions.
When it comes to solubility, it is slightly soluble in organic solvents such as methanol, ethanol, and dichloromethane. However, in water, the solubility is very small, because its molecular structure is dominated by hydrophobic groups, resulting in poor hydrophilicity.
Its melting point has been determined to be about a certain temperature range, which is of great significance for its identification and purity determination. During the heating process, when a certain temperature is reached, the substance will melt from the solid state to the liquid state, and this melting point range is one of its important physical markers.
At the level of chemical properties, the benzimidazole ring, pyridine ring and sulfur-containing groups in the compound endow it with various reactivity. The nitrogen atom of the benzimidazole ring can participate in various nucleophilic reactions; the substituent group on the pyridine ring has a great influence on the distribution of its electron cloud, which in turn affects its reactivity and selectivity. The sulfur atom containing the sulfur group has a lone pair of electrons, which can participate in the reaction as a nucleophilic reagent, and can also undergo oxidation and other reactions under appropriate conditions.
Due to its unique physicochemical properties, 2-% 5B% 7B4-% 283-methoxypropoxy% 29-3-methylpyridine-2-yl% 7D-methylthio% 5D-1H-benzimidazole has shown high potential application value in organic synthesis, medicinal chemistry and other fields.
2- [{4- (3-Methoxypropoxy) -3-methyl pyridine-2-yl} methylthio] -1H-benzimidazole What are the precautions during use?
2-% 5B% 7B4-% 283-methoxypropoxy% 29-3-methylpyridine-2-yl% 7D-methylthio% 5D-1H-benzimidazole This product has several ends to pay attention to when using it.
The first one concerns its chemical properties. This is an organic compound with specific groups such as benzimidazole and pyridine in its structure, and its chemical activity and stability depend on these groups. If it encounters with strong oxidizing agents, strong acids and bases, or reacts violently, it will cause the components to deteriorate or produce dangerous products. Therefore, when storing, it is necessary to keep it away from such dangerous chemicals and keep it in a dry, cool and ventilated place to prevent its chemical properties from being changed by external influences.
The second is toxicity and safety. Although its exact toxicity is not known, there are many potential health risks in organic compounds. When operating, be sure to take good protection. In front of laboratory clothes, gloves and goggles, avoid direct contact with the skin and eyes. If you accidentally touch it, you should rinse it with plenty of water and seek medical attention according to the specific situation. The operating environment should also be well ventilated to prevent inhalation of its volatiles and damage to the respiratory tract and nervous system.
In addition, the use of norms is also important. Before use, be sure to read the relevant literature and operating instructions carefully to understand the correct use methods and procedures. In the experiment, the dosage and reaction conditions are precisely controlled in strict accordance with the operating procedures. If chemical reactions are involved, temperature, time, and the proportion of reactants will affect the purity and yield of the product. A slight poor pool may cause experimental failure or even safety accidents.
In addition, waste treatment cannot be ignored. Residues, reaction products and other wastes after use should not be discarded at will. According to chemical waste treatment specifications, they should be collected and properly disposed of to prevent environmental pollution.