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What are the main uses of 2- (3-aminophenyl) -5-aminobenzimidazole?
2-% (3-aminophenyl) -5-aminobenzoxazole, which is mainly used in the field of organic synthesis. In medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. Due to the amino and benzoxazole structures contained in this structure, it has unique chemical and biological activities. It can be chemically modified to construct a variety of complex molecular structures with specific pharmacological activities.
In the field of materials science, 2-% (3-aminophenyl) -5-aminobenzoxazole also plays an important role. After polymerization, high-performance polymer materials can be prepared. Such materials exhibit excellent thermal stability, mechanical properties and electrical properties due to their special molecular structure, and are widely used in high-end fields such as aerospace, electronics and electrical appliances. For example, in the aerospace field, the prepared polymer materials can be used to make internal structural components of aircraft. Due to their good thermal stability and mechanical properties, they can meet the strict requirements of aircraft in extreme environments. In the field of electronics and electrical appliances, because of their good electrical properties, they can be used to make insulating materials for electronic components.
In addition, in dye chemistry, the compound can be used as a raw material for the synthesis of new dyes due to its own structural properties. By modifying and adjusting its structure, dyes with specific colors, photostability and dyeing properties can be obtained, which can be used in textiles, printing and dyeing industries.
What are the synthesis methods of 2- (3-aminophenyl) -5-aminobenzimidazole
In order to prepare 2- (3-aminophenyl) -5-aminobenzoxazole, there are many synthesis methods.
can start from aniline compounds containing corresponding substituents, and construct benzoxazole structures through cyclization. For example, specific substituents are modified for aniline first, the desired group is introduced at a suitable position, and then the cyclization reagent is used to promote the cyclization and condensation of amino groups with ortho-hydroxyl groups (or groups that can be converted to hydroxyl groups) under suitable reaction conditions to form benzoxazole rings, thereby obtaining the target product. < Br >
Or starting from the parent structure of benzoxazole, the 2- (3-aminophenyl) and 5-amino groups can be gradually introduced through electrophilic substitution, nucleophilic substitution and other reactions. Moderately active halogenated aromatics and amino-containing nucleophiles can be used to undergo nucleophilic substitution in the presence of bases to introduce 3-aminophenyl groups into the 2-position of benzoxazole; subsequently, similar methods or other suitable amination strategies can be used to introduce amino groups at the 5-position.
can also be achieved by the reaction catalyzed by transition metals. For example, in a palladium-catalyzed cross-coupling reaction, a benzopazole derivative containing a suitable functional group is coupled with an aryl halide or other electrophilic reagent to precisely construct the carbon-carbon bond and carbon-nitrogen bond of the target molecule, thereby completing the synthesis of 2- (3-aminophenyl) -5-aminobenzopazole. In the reaction, factors such as catalyst dosage, reaction temperature, reaction time and solvent need to be strictly controlled to improve the reaction yield and selectivity.
What are the physicochemical properties of 2- (3-aminophenyl) -5-aminobenzimidazole?
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2- (3-hydroxyphenyl) -5-hydroxybenzofuranone, this compound has certain unique physicochemical properties. From the perspective of physical properties, its appearance often shows a specific crystalline form. Due to the arrangement and interaction of atoms in the molecular structure, its crystallization has specific crystal forms and lattice parameters. Its melting point and boiling point are also determined by intermolecular forces. Intermolecular hydrogen bonds, van der Waals forces, etc., maintain the melting point and boiling point in a specific range, and the phase state transition occurs at the corresponding temperature.
Chemically, due to the structure of the molecule containing hydroxyl groups and benzofuranone, it has significant chemical activity. Hydroxyl groups are active functional groups and are easy to participate in many chemical reactions. For example, they can be esterified with acids to form corresponding ester compounds. During this process, hydroxyl hydrogen atoms are replaced by acid groups and form new compounds through covalent bonds. At the same time, hydroxyl groups can be oxidized, and different oxidation products such as aldehyde groups and carboxyl groups can be formed depending on the type of oxidant and reaction conditions. The structure of benzofuranone endows the compound with a certain conjugated system, which makes it have a unique electron cloud distribution and chemical stability. The conjugated system deloculates electrons and enhances molecular stability. Under certain conditions, electrophilic substitution reactions can occur. The hydrogen atoms on the aromatic ring are replaced by electrophilic reagents to form a variety of derivatives, showing rich chemical properties and reactivity. These physicochemical properties make it important in organic synthesis, drug research and development and other fields.
What is the market price of 2- (3-aminophenyl) -5-aminobenzimidazole?
I look at what you said, the price of the "2- (3-aminophenyl) -5-aminobenzothiazole" involved in the market varies for many reasons.
First, the quality is different, if its purity is high and impurities are few, it is suitable for high-end scientific research and fine chemical fields, and the price will be high; if the purity is slightly inferior, it is only for general industrial use, and the price is slightly lower.
Second, in the situation of supply and demand, if there are many people in the market and few products, the so-called "rare things are expensive", the price will rise; on the contrary, if the supply is abundant and the demand is flat, the price will stabilize or fall.
Third, the difficulty of production. If the synthesis of this compound requires complicated processes, special raw materials or harsh conditions, the cost will be high, and the price will rise accordingly; if the production is easier and the cost is controllable, the price will be reduced.
Fourth, brand and after-sales, produced by well-known manufacturers, with reliable quality and detailed after-sales service. Although the price is high, some people will follow it; if it is produced by an unknown person, the vertical price is low, or no one is interested.
As far as I know, the price of this compound per gram in the market can range from tens of yuan at least to hundreds of yuan at most, or even higher. It is difficult to generalize. Those who need to buy should carefully observe the market, measure their needs, and find the best price.
What are the application fields of 2- (3-aminophenyl) -5-aminobenzimidazole
2-% (3-aminophenyl) -5-aminobenzoxazole has applications in many fields.
In the field of materials science, due to its unique chemical structure and properties, it can be used as a raw material for the preparation of high-performance polymers. After rational design and synthesis, it can be introduced into the main or side chains of polymers, imparting properties such as excellent thermal stability, mechanical properties and optical properties. For example, in the preparation of polymer materials used in aerospace, the addition of this substance can improve the material's high temperature resistance and mechanical strength, meeting the needs of extreme conditions.
In the field of medicinal chemistry, this compound has potential biological activity. Its special molecular structure can interact with specific targets in organisms, or exhibit pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor. Scientists can use it as a lead compound to develop new therapeutic drugs through structural modification and optimization. For example, the development of targeted therapeutic drugs for certain tumor cells, the structural properties of this compound may help to achieve precise effects on tumor cells and reduce damage to normal cells.
In the field of organic synthesis, it is an important intermediate. With the reactivity of amino and benzoxazole structures, it can participate in a variety of organic reactions, such as nucleophilic substitution, cyclization reactions, etc., for the construction of more complex organic molecular structures, providing organic synthesis chemists with rich synthesis strategies and methods to help synthesize organic compounds with specific functions and structures.