2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide

This is the chemical structure analysis of 2- [ (2R) -2 -methylpyrrolidine-2-yl] -1H -benzimidazole-4-formamide. Among its structures, there is a core structure of benzimidazole, which is two fused aromatic rings, one is a benzene ring and the other is an imidazole ring, and the two share two edges. Unsubstituted at the 1H position of benzimidazole, there is a formamide group at the 4th position. This formamide is composed of a carbonyl-linked amino group. The carbonyl group is electrophilic and the amino group is nucleophilic. It plays an important role in many chemical reactions and biological activities.
Furthermore, [ (2R) -2 -methylpyrrolidine-2-yl] connected to benzimidazole is a chiral five-membered nitrogen-containing heterocycle. The 2-methylpyrrolidine-2-group is connected to benzimidazole through its 2-position. This chiral center (2R configuration) is crucial in determining the stereochemical properties and biological activities of the compound, and different configurations may lead to significant differences in biological activities.
In summary, the chemical structure of 2- [ (2R) -2 -methylpyrrolidine-2-yl] -1H -benzimidazole-4 -formamide fuses benzimidazole, formamide and chiral pyrrolidine groups, the interaction of each part determines the physical, chemical and biological properties of the compound.

2-% 5B% 282R% 29-2-methylpyrrolidine-2-yl% 5D-1H-benzimidazole-4-formamide is an organic compound. This substance has specific physical properties.
Looking at its properties, under normal temperature and pressure, it is mostly in a white to quasi-white solid state, with a fine texture and is as pure as early winter snow. Its melting point is between 190 and 195 ° C. It is like a key threshold for the internal order of matter. When the temperature rises to this point, the intermolecular forces begin to rearrange and combine, and the solid state quietly changes to the liquid state.
In terms of solubility, the compound exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethyl formamide (DMF), just like a fish entering water, the molecules can freely swim and disperse in the arms of the solvent; however, the solubility in water is poor, just like the incompatibility of oil and water, the molecules are difficult to distribute uniformly surrounded by water molecules.
Its density is about 1.3-1.4 g/cm ³, which means that under the same volume, it is denser and has a heavy texture than common light substances. In addition, the stability of the compound is relatively good. Under normal temperature, humidity, and lighting conditions, it can maintain the stability of its own structure and properties, like a sturdy castle that resists the erosion of the external environment and is not prone to decomposition or other chemical reactions.

2-% 5B% 282R% 29-2-methylpyrrolidine-2-yl% 5D-1H-benzimidazole-4-formamide, which is often involved in the field of pharmaceutical chemistry. Its main use is related to drug research and development.
In pharmaceutical chemistry research, such compounds containing specific structures are often key starting materials for the creation of new drugs. Due to their unique chemical structure, capsules can interact with specific targets in organisms. If they can precisely dock biological macromolecules, or can regulate the physiological and biochemical processes of the body, in order to achieve the purpose of treating diseases.
Looking at past studies, many compounds containing benzimidazole and pyrrolidine structures have exhibited pharmacological activities such as antibacterial, antiviral, and antitumor. 2-% 5B% 282R% 29-2-methylpyrrolidine-2-yl% 5D-1H-benzimidazole-4-formamide or similar potential. After rational structural modification and activity screening, it is expected to be developed as a specific drug for specific diseases.
In addition, this compound can be used as an important model in the study of drug structure-activity relationship. By systematically changing its substituents, exploring the effects of structural changes on activity, selectivity and pharmacokinetic properties can provide a solid theoretical basis for the design of better drugs, and help drug development move towards high efficiency and low toxicity.

To prepare 2 - [ (2R) -2 -methylpyrrolidine-2-yl] -1H -benzimidazole-4-formamide, there are many methods. Common, or first take a suitable starting material, through organic synthesis, obtained by several steps of reaction.
One method can be based on benzimidazole first, and a formyl group can be introduced at its 4 position. This step may require specific reagents and reaction conditions. For example, with an acylating agent, in the presence of an appropriate solvent and catalyst, benzimidazole is acylated to obtain 4-formyl benzimidazole derivatives.
Then, try to introduce [ (2R) -2 -methylpyrrolidine-2-yl]. Or find a compound containing [ (2R) -2 -methylpyrrolidine-2-yl], and connect it with the obtained 4-formyl benzimidazole derivative by means of condensation reaction. For this condensation reaction, a suitable base or catalyst may be selected to promote the reaction, and the reaction temperature and time need to be controlled to achieve the best reaction effect.
There are other methods, the pyrrolidine ring part can be constructed first, and then combined with the benzimidazole structure. The pyrrolidine precursor containing a specific substituent is prepared first, and then a pyrrolidine ring is formed by cyclization reaction, and its configuration is ensured to be (2R) -2-methylpyrrolidine-2-yl. Then, the pyrrolidine derivative is connected to the benzimidazole-related intermediate through a suitable reaction path, such as nucleophilic substitution, coupling reaction, etc., to form the target product 2 - [ (2R) -2-methylpyrrolidine-2-yl] -1H-benzimidazole-4-formamide. However, each method requires fine regulation of reaction conditions, and focuses on the purification and identification of intermediates in order to obtain pure products.

2 - [ (2R) -2 -methylpyrrolidine-2-yl] -1H -benzimidazole-4-formamide. When using this substance, all matters need to be paid attention to.
The first one concerns its chemical properties. This is an organic compound. In the structure, the parts of benzimidazole and pyrrolidine are connected to each other, and the chemical activity is particularly critical. Due to its complex structure, under different chemical reaction conditions, there may be different reaction paths. When using it, it is necessary to know its chemical properties in detail and understand the possible reactions to prevent accidental side reactions.
Furthermore, safety protection must not be ignored. Organic compounds, which may be toxic or irritating. To handle this substance, appropriate protective equipment, such as gloves, goggles, and even gas masks, is required, depending on the specific situation. If you accidentally come into contact with the skin or eyes, you should immediately rinse with plenty of water, and seek medical attention in a timely manner according to the severity of the injury. And this substance should also be stored with caution. It should be stored in a cool, dry, and ventilated place, away from fire sources and oxidants to prevent dangerous chemical reactions.
In addition, accurate measurement is of paramount importance. For scientific research, production, and other purposes, the dosage needs to be precisely controlled. Minor measurement deviations, or deviations in experimental results, or product quality problems in the production process. Therefore, before use, when calibrating the measuring instrument, ensure that the dosage is correct.
In addition, it is also important to know the physical properties such as solubility and stability of this substance. Different solvents have different solubility, so choose a suitable solvent to achieve the best use effect. The stability is related to the shelf life and use time, and it needs to be properly disposed of according to its characteristics.
In general, the use of 2- [ (2R) -2 -methylpyrrolidine-2-yl] -1H -benzimidazole-4-formamide requires more attention to chemical properties, safety protection, accurate measurement, and physical properties in order to achieve the intended purpose and ensure safety.