2-(1H-imidazole-1-yl)acetonitrile

2-%281H-imidazole-1-yl%29acetonitrile, Chinese name 2- (1H-imidazole-1-yl) acetonitrile, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it is a key intermediate. In many drug development processes, it can be cleverly combined with other compounds through specific chemical reactions to build molecules with complex structures and specific pharmacological activities. For example, in the preparation of some antibacterial drugs, it participates in reactions, giving drugs better antibacterial properties and biological activities, helping to fight bacterial infections.
In the field of materials science, it also has important uses. It can be used as a functional monomer, which can be integrated into polymer material systems by means of polymerization reactions, etc., thereby giving materials unique properties. For example, in the preparation of some polymer materials with special adsorption or recognition functions, the addition of 2- (1H-imidazole-1-yl) acetonitrile can make the material exhibit high selective adsorption capacity for specific substances, and play an important role in the field of separation and detection.
In organic synthetic chemistry, it is an extremely important building block. Because of the active groups contained in its molecular structure, it can carry out a variety of chemical reactions, such as nucleophilic substitution, addition, etc., to build different types of organic compounds, providing a rich material basis and reaction path for the development of organic synthetic chemistry. In short, 2- (1H-imidazole-1-yl) acetonitrile plays an indispensable role in many fields, promoting the sustainable development and progress of various fields.

2-% (1H-imidazole-1-yl) acetonitrile, that is, 2- (1H-imidazole-1-yl) acetonitrile. The synthesis method of this product has the following methods.
First, 1H-imidazole and bromoacetonitrile are used as raw materials. The two are mixed in a suitable solvent, such as dimethylformamide (DMF), with an appropriate base, such as potassium carbonate, and stirred at a suitable temperature. The function of the base is to capture the protons on 1H-imidazole to form a nucleophilic reagent, which then undergoes a nucleophilic substitution reaction with bromoacetonitrile to form 2- (1H-imidazole-1-yl) acetonitrile. The reaction process needs to pay attention to the control of temperature. Excessive temperature may trigger side reactions and reduce the purity of the product.
Second, 1 - (2-hydroxyethyl) imidazole is used as the starting material. First, it is reacted with a suitable halogenating reagent, such as phosphorus tribromide or sulfoxide chloride, to convert the hydroxyl group into a halogen atom to obtain 1 - (2-haloethyl) imidazole. Subsequently, this product is reacted with cyanide reagents such as sodium cyanide or potassium cyanide in an appropriate solvent, such as ethanol-water mixed solvent, and the halogen atom is replaced by cyanyl group to obtain 2- (1H-imidazole-1-yl) acetonitrile. This method has a little more steps, but the reaction conditions of each step are relatively mild and easy to control.
Third, imidazole can also be reacted with 2-chloroacetonitrile in the presence of a phase transfer catalyst. Phase transfer catalysts can promote the reaction to be carried out more efficiently in two-phase systems. Commonly used phase transfer catalysts include quaternary ammonium salts. Under suitable temperature and stirring conditions, the nitrogen atom of imidazole attacks the chlorine atom of 2-chloroacetonitrile to form the target product. The advantage of this method is that the reaction conditions are relatively simple, and the reaction rate and yield can be improved.
The above methods have their own advantages and disadvantages. In the actual synthesis, the most suitable method should be selected according to the comprehensive consideration of factors such as raw material availability, cost, and product purity requirements.

2-%281H-imidazole-1-yl%29acetonitrile is 2- (1H-imidazole-1-yl) acetonitrile, which is an organic compound. Its physical and chemical properties are as follows:
Looking at its properties, at room temperature, 2- (1H-imidazole-1-yl) acetonitrile is often in a solid state, or a white to off-white powder, its powder is delicate and uniform in texture. This form is easy to store and use, and it is also conducive to subsequent chemical operations.
When it comes to solubility, this compound exhibits a certain solubility in common organic solvents, such as ethanol, dichloromethane, N, N-dimethylformamide (DMF), etc. In ethanol, moderate heating and stirring can be better dissolved to form a homogeneous solution. However, in water, its solubility is poor and only slightly soluble. This solubility characteristic is related to the imidazolyl and acetonitrile groups contained in the molecular structure. Imidazolyl has a certain polarity, but the presence of acetonitrile groups limits the hydrophilicity of the molecule as a whole.
In terms of melting point, the melting point of 2- (1H-imidazolyl-1-yl) acetonitrile is within a specific range, which is an important physical property. Accurate determination of melting point can be used to identify the purity of the compound. If the compound has high purity, the melting point range is relatively narrow and close to the theoretical value; if it contains impurities, the melting point will be reduced and the melting range will be wider.
In terms of chemical properties, the imidazole ring of 2- (1H-imidazole-1-yl) acetonitrile has electron-rich properties and is prone to electrophilic substitution reactions. If it reacts with halogenated hydrocarbons, substituents can be introduced at specific positions of the imidazole ring, and then a variety of compounds can be derived. At the same time, the carbon-nitrogen triple bond of the acetonitrile group has high reactivity, which can be hydrolyzed and converted into the corresponding carboxylic acid or carboxylate under acidic or basic conditions; it can also participate in nucleophilic addition reactions and react with compounds containing active hydrogen, such as alcohols and amines, to form new carbon-heteroatomic bonds, which have important application value in the field of organic synthesis.

It is difficult to determine the price range of 2-% (1H-imidazole-1-yl) acetonitrile in the market. This is due to the changeable market conditions, and the price is subject to various factors.
If the raw materials, the abundance of raw materials and the rise and fall of prices can cause the price of 2-% (1H-imidazole-1-yl) acetonitrile to fluctuate. If the raw materials are abundant and easy to harvest, the price may be stable and cheap; if the raw materials are thin and difficult to find, the price will rise.
Furthermore, the method of production also has an impact. A good method can increase the yield, reduce wear and tear, and control the cost, so the price is appropriate; if the law is poor, the production is low and the consumption is high, and the price will be expensive.
The supply and demand of the city is also due to this. If there is a demand for many and the supply is small, the price will rise; if there is too much supply and less demand, the price will drop. And different places, due to differences in logistics, taxes, and regulations, the price is also different.
Therefore, if you want to know the exact price of 2-% (1H-imidazole-1-yl) acetonitrile, you should consult chemical material suppliers, market research agencies, or check in detail on the chemical trading platform to get a close price.

2-% (1H-imidazole-1-yl) acetonitrile, Chinese name 2- (1H-imidazole-1-yl) acetonitrile, is an important intermediate in organic synthesis, and is widely used in various fields such as medicine, pesticides and materials. Its manufacturers are all over the world, the following are some of them:
- ** Sigma-Aldrich Company **: This is a global leader in the field of chemical reagents and scientific research products. The 2- (1H-imidazole-1-yl) acetonitrile provided by Sigma-Aldrich is of high quality and has a variety of packaging specifications. It can meet the needs of different users, whether it is a small number of experiments in scientific research institutions or a large number of purchases in industrial production.
- ** TCI (Tokyo Chemical Industry Co., Ltd.) **: As a well-known chemical reagent supplier, TCI has extremely strict control over product quality. The 2- (1H-imidazole-1-yl) acetonitrile it produces has high purity and good stability. It has a good reputation in the field of organic synthetic chemistry and is favored by researchers and enterprises.
- ** Alfa Aesar Company **: It is known for providing high-quality metal and ceramic materials, organic chemical reagents, etc. The company's 2- (1H-imidazole-1-yl) acetonitrile products are not only reliable in quality, but also have excellent cost performance. They are commonly used by many enterprises and scientific research institutions.
- ** Some domestic manufacturers **: In China, there are also many chemical companies engaged in the production of 2- (1H-imidazole-1-yl) acetonitrile. For example, some fine chemical companies located in Jiangsu, Zhejiang and other places are actively involved in the production of this product by virtue of their own technology and cost advantages. Its products not only supply the domestic market, but also some are exported overseas, accounting for a certain share in the global market.