2'-(1H-Imidazole-1-yl)-2,4-dichloroacetophenone

2%27-%281H-Imidazole-1-yl%29-2%2C4-dichloroacetophenone is 2 '- (1H-imidazole-1-yl) -2,4-dichloroacetophenone, which has a wide range of uses. In the field of medicine, it is often used as a key intermediate to assist in drug synthesis. Due to its structure, imidazolyl and dichloroacetophenone parts endow unique chemical activity and binding properties, and can participate in many reactions, laying the foundation for the creation of drugs with specific pharmacological activities, such as the preparation of certain antibacterial and antiviral drugs, which interact with specific targets to achieve therapeutic purposes.
In the field of materials science, it also plays an important role. Its special structure can improve material properties, such as for the preparation of functional polymer materials, to improve material stability, conductivity or optical properties. In the field of organic synthetic chemistry, it is an important reaction substrate and participates in many organic reactions. Through structural modification and modification, complex organic compounds are constructed, and the variety and application range of organic compounds are expanded. In short, 2 '- (1H-imidazole-1-yl) -2,4-dichloroacetophenone has important value in many fields, promoting continuous development and innovation in various fields.

2%27-%281H-Imidazole-1-yl%29-2%2C4-dichloroacetophenone that is, 2 '- (1H-imidazole-1-yl) -2,4-dichloroacetophenone. There are many methods for its synthesis.
One is to use 2,4-dichloroacetophenone and imidazole as raw materials and react under alkali catalysis. This is a classic method, often using potassium carbonate, sodium hydroxide, etc. as bases. First, place 2,4-dichloroacetophenone and imidazole in a reaction vessel in an appropriate ratio, add an appropriate amount of organic solvents, such as N, N-dimethylformamide (DMF), acetonitrile, etc., then add alkali, heat up and stir. In the reaction, the base captures the proton of imidazole to form an imidazole negative ion. This negative ion attacks the carbonyl α-carbon of 2,4-dichloroacetophenone and generates the target product through a nucleophilic substitution reaction. After the reaction is completed, the pure product can be obtained by separation, washing, column chromatography and other separation and purification methods.
Second, 2,4-dichloroacetophenone can be activated first, such as by conversion to acid chloride. React with 2,4-dichloroacetophenone with sulfoxide chloride and other reagents to obtain 2,4-dichloroacetyl chloride. Afterwards, it is reacted with imidazole in the presence of acid binding agents. Acid binding agents such as triethylamine can neutralize the hydrogen chloride generated by the reaction. In this reaction process, the nitrogen atom of imidazole attacks the carbonyl group of the acid chloride to form an intermediate, and then the chloride ion is removed to produce 2 '- (1H-imidazole-1-yl) -2,4-dichloroacetophenone. Similarly, regular separation operations are required after the reaction, such as extraction, distillation, recrystallization, etc., to achieve the purpose of purification.
There are also those who use 2,4-dichlorobenzoic acid as the starting material. First, it is converted into 2,4-dichlorobenzoyl chloride, and then reacted with diazomethane to form diazone. After Wolff rearrangement, 2,4-dichlorobenzophenone is obtained, and then reacted with imidazole. Although there are many steps in this process, it is also a way of synthesis.
The above methods have their own advantages and disadvantages, and they need to be used according to actual needs, such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.

2%27-%281H-Imidazole-1-yl%29-2%2C4-dichloroacetophenone, this is an organic compound. Its physical and chemical properties are quite characteristic.
Looking at its appearance, under room temperature and pressure, or in a solid state, it often takes the shape of white to light yellow crystalline powder, just like the first snow in the mountains, pure and simple.
When talking about the melting point, it is about a specific temperature range. This temperature is the key node for the conversion of the compound from a solid state to a liquid state. When melting snow, it has its own inherent value, which is one of the important indicators for identifying this compound.
In terms of solubility, in organic solvents, such as common ethanol, dichloromethane, etc., it has a certain solubility, just like fish entering water and can dissolve with it; however, in water, the degree of solubility is extremely low, just like oil droplets in water, difficult to integrate. This solubility characteristic is crucial for its separation, purification and application in different reaction systems.
Chemically, its molecular structure contains 1H-imidazole-1-group and 2,4-dichloroacetyl group, which give the compound unique reactivity. The nitrogen atom of 1H-imidazole-1-yl has a lone pair of electrons, which can be used as a nucleophilic reagent to participate in many nucleophilic substitution reactions. If it encounters with halogenated hydrocarbons, nucleophilic substitution will occur, and new compounds will be formed, just like particles that attract each other and combine with each other. The chlorine atom of 2,4-dichloroacetyl is active and easy to be attacked by nucleophilic reagents, and substitution reactions occur, providing various possibilities for organic synthesis. And under suitable conditions, this compound may participate in oxidation, reduction and other reactions, and deduce various chemical changes on the stage of organic chemistry.

I look at your question, and I am inquiring about the market price range of 2- (1H-imidazole-1-yl) -2,4-dichloroacetophenone. However, the price of this chemical product changes for many reasons.
First, the price of the raw materials of the product fluctuates, which affects its cost, and then causes the price to be different. If the raw materials are easily available and cheap, the price may be low; if the raw materials are scarce and difficult to find, the price must be high.
Second, the process of preparing this compound is also related to the simplicity. If the process is complicated, high-end equipment and exquisite technology are required, and the cost increases and the price also rises; if the process is simple, the cost decreases and the price also decreases.
Third, the state of market supply and demand is the key. If the demand is strong and the supply is small, merchants may raise the price in pursuit of profit; if the supply exceeds the demand, the price may be reduced in order to sell the goods.
Fourth, the purity of the product also affects the price. For high purity, the preparation is difficult, the cost is high, and the price is expensive; for low purity, the price is relatively cheap.
As far as I know, on the market, this 2- (1H-imidazole-1-base) -2,4-dichloroacetophenone has a wide price range due to the above factors. Roughly speaking, the price per gram may range from tens to hundreds of yuan. However, this is only an approximate amount, and the actual price shall be subject to the quotation of each supplier and the specific transaction situation.

I heard that today there is a product called 2- (1H-imidazole-1-yl) -2,4-dichloroacetophenone, and the world wants to know its manufacturer. This is an important compound in the field of fine chemicals and is widely used in medicine, pesticides, materials and other industries.
In the land of China, there are many manufacturers involved in the production of this product. For example, in the land of Jiangsu and Zhejiang, there is a factory named [Manufacturer A], which has a reputation for its production with exquisite craftsmanship and advanced equipment. The factory has strict quality control, and the 2- (1H-imidazole-1-base) -2,4-dichloroacetophenone produced is of high quality and is favored by many downstream enterprises.
There is also Qilu's domain, and [Manufacturer B] is also involved in this. Its research and development force is strong, and it constantly improves production technology, striving for better products. The products produced are not only supplied at home, but also exported overseas, and have won a place in the international market.
Furthermore, in the land of Huguang, [Manufacturer C] is also producing this product. The factory pays attention to environmental protection and innovation, and adopts green production technology, which not only guarantees product quality, but also fits the current environmental protection trend. In the market, its products are known for their stability and reliability.
In addition, there are also manufacturers in the land of Sichuan and Shu engaged in this industry. [Manufacturer D] With its geographical advantages and technological accumulation, it produces 2- (1H-imidazole-1-base) - 2,4-dichloroacetophenone, which occupies an important share in the southwest market and contributes to the development of the local chemical industry.
These manufacturers are all important producers of 2- (1H-imidazole-1-base) - 2,4-dichloroacetophenone, each with its own strengths and has contributed greatly to the prosperity of the industry.