1H-Imidazole-4-ethanol

1H-imidazole-4-ethanol has a wide range of uses and is used in various fields of medicine and chemical industry.
In the field of medicine, it is an important intermediate in organic synthesis. The preparation of many drugs depends on its participation in the reaction to form a specific chemical structure. For example, some drugs for the treatment of cardiovascular diseases, when synthesizing, 1H-imidazole-4-ethanol can be a key starting material. After a series of delicate chemical reactions, a molecular structure with specific pharmacological activities is gradually constructed to help the drug achieve the effect of regulating cardiovascular function.
In the chemical industry, it is also an indispensable ingredient. In the preparation process of some high-performance polymers, it can be introduced as a functional monomer, giving the polymer special properties. For example, to make the polymer have better heat resistance, chemical resistance, or improve its mechanical properties, which is of great significance in the research and development and production of high-end materials. In addition, in fine chemical products, such as the synthesis of some special surfactants, the unique structure of 1H-imidazole-4-ethanol can help adjust the hydrophilic and lipophilic balance of surfactants, and improve its emulsification and dispersion properties in different systems. It is widely used in daily chemicals, coatings and other industries.

The physical properties of 1H-imidazole-4-ethanol are particularly important for its application in various fields. The following is a detailed description of it.
Looking at its appearance, it is mostly white to light yellow crystalline powder under normal conditions. This form makes it easy to handle in many operations, and the characteristics of the powder make it well dispersed. In process steps such as mixing, it can blend with other substances more uniformly.
When it comes to melting point, it is within a specific range. This characteristic is an important indication for its operation in heating or melting. When the temperature approaches the melting point, its physical state will change, from solid state to liquid state, and this transition process is crucial to the temperature control of the production process, which is related to the quality and performance of the product.
Solubility is also a key property. 1H-imidazole-4-ethanol exhibits a certain solubility in some common organic solvents and a moderate solubility in water. This property makes it available in the preparation of solutions, formulations, etc. According to different needs, suitable solvents can be selected to achieve the required concentration and dispersion state to meet the needs of fields such as chemical reaction media and drug formulations.
Furthermore, its density is also an important physical parameter. Although the specific value depends on specific conditions, the density affects its distribution and sedimentation behavior in the mixed system. In the liquid mixture system, the density difference determines whether it floats or sinks, which in turn affects the uniformity and stability of the mixture.
In addition, its hygroscopicity is also worthy of attention. Due to different environmental humidity, 1H-imidazole-4-ethanol may absorb a certain amount of water. Hygroscopicity not only affects its own storage stability, but also affects the overall performance of the product if used in a specific product, such as affecting the shelf life and efficacy of the drug.
In summary, the physical properties of 1H-imidazole-4-ethanol, from appearance, melting point, solubility, density to hygroscopicity, have a profound impact on its application and processing in chemical, pharmaceutical and other fields, and need to be carefully considered in practical applications.

The synthesis method of 1H-imidazole-4-ethanol has been known for a long time, and is now described by you.
First, 4-cyanimidazole is used as the starting material. First, 4-cyanimidazole and lithium aluminum hydride are reacted slowly in a suitable organic solvent, such as anhydrous tetrahydrofuran, at low temperature and protected by inert gas. Lithium aluminum hydride is highly reducible, and the cyano group can be gradually reduced to hydroxymethyl groups. After this step, the intermediate product can be properly treated, such as under mild acidic conditions, to further convert it to 1H-imidazole-4-ethanol. This process requires fine control of the reaction temperature, time and reagent dosage, otherwise it is easy to cause side reactions and affect the purity and yield of the product.
Second, 4-nitroimidazole is used as the starting material. 4-nitroimidazole is reduced with suitable reducing agents, such as iron powder and hydrochloric acid system, or hydrogen under palladium-carbon catalysis. Nitro is reduced into amino groups, and then halogenated ethanol and amino-containing intermediate products are reacted in suitable solvents under base catalysis. The base can be selected from potassium carbonate, etc., and the solvent can be selected from N, N-dimethylformamide. This reaction undergoes nucleophilic substitution, and the amino group attacks the halogen atom of halogenated ethanol to eventually generate 1H-imidazole-4-ethanol. This route requires attention to the degree of reduction reaction and the optimization of nucleophilic substitution conditions.
Third, imidazole and ethylene oxide are used as raw materials. Under the action of catalysts, such as some Lewis acid catalysts, at appropriate temperature and pressure, the nitrogen atom of imidazole undergoes nucleophilic ring-opening reaction on ethylene oxide. This reaction is relatively direct, but the reaction conditions need to be controlled to ensure the selectivity of the ring opening position of ethylene oxide, so that the reaction mainly generates 1H-imidazole-4-ethanol, rather than other position isomers. At the same time, attention should be paid to the safety of the reaction system, as ethylene oxide poses certain risks.

The price of 1H-imidazole-4-ethanol in the market often varies with quality, source, quantity and market conditions, so it is difficult to determine.
Watching the market conditions of the past, if the quantity is small and the purchase price is slightly high; if the purchase is large, the price should be reduced. In ordinary trade, the price per gram may be in the range of a few yuan to a few dozen yuan. However, this is only an approximate number and cannot be determined.
And the quality of the husband is also the main reason for the price. Those with high purity must be higher than those of ordinary people. And the distance of the supply and the simplicity of transportation can make the price fall and rise.
If you want to know the exact price, you can ask the chemical raw material supplier, reagent supplier, or visit the network of chemical product trading, and you can get a near-real price compared to the reports of others. The market is volatile, and the price is also changeable. Buyers should consider the situation to get an appropriate price.

1H-imidazole-4-ethanol, this substance should be stored in a cool, dry and well-ventilated place. Due to its nature or sensitivity to temperature and humidity, too high temperature may cause it to decompose and deteriorate; too humid environment may also make it damp and affect its quality.
Therefore, the storage temperature should be controlled between 15 ° C and 25 ° C. This temperature range can ensure that its chemical properties are relatively stable and not easy to change. The humidity of the air should be maintained at 40% to 60%. In this way, it can prevent its moisture absorption, agglomeration and other phenomena.
And it needs to be stored separately from oxidants, acids, bases and other substances. There may be a chemical reaction between 1H-imidazole-4-ethanol and other such substances, which may cause changes in their properties and even cause danger. The storage place should also be kept away from fire and heat sources, and fireworks should be strictly prohibited to avoid the risk of fire.
At the same time, storage containers should also be selected carefully. A well-sealed container should be used to prevent it from evaporating or reacting with components in the air. After taking it, it should be sealed immediately to maintain the stability of its storage environment. If it can be properly stored under these conditions, the quality of 1H-imidazole-4-ethanol can be guaranteed for subsequent use.