1h Imidazole 4 Ethanamine Chloride 1 1
quinoline thiophene imidazole thiazole

1H-imidazole-4-ethanamine, chloride (1:1)

    Specifications

    HS Code

    893980

    Chemical Name 1H-imidazole-4-ethanamine, chloride (1:1)
    Molecular Formula C5H9ClN4
    Molar Mass 160.605 g/mol
    Appearance Solid
    Solubility Soluble in water
    Melting Point 220 - 224 °C
    Pka 7.05
    Logp -0.49

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    Frequently Asked Questions

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    1H-imidazole-4-ethanamine, what is the chemical structure of chloride (1:1)
    1H-imidazole-4-ethylamine hydrochloride (1:1), its chemical structure is as follows. In this substance, the imidazole ring is a five-membered heterocyclic ring containing two nitrogen atoms, showing a planar structure. The hydrogen atom at position 1 indicates that the position has not been replaced by other groups. The 4-position imidazole ring is connected to the ethylamine group, which is connected by two methylene (-CH ² -) groups, one end is connected to the imidazole ring, and the other end is the amino group (-NH ²). The hydrochloride form means that the amino group reacts with hydrogen chloride (HCl) to form an ammonium salt structure, that is, the nitrogen atom of the amino group binds to the hydrogen ion with a positive charge, and the chloride ion (Cl) forms an ionic bond with it to achieve electrical neutrality. In the overall structure, each atom is connected by covalent bonds, presenting a specific spatial configuration and chemical activity. This structure endows the compound with unique physical and chemical properties, and has important applications in the fields of organic synthesis and medicinal chemistry.
    1H-imidazole-4-ethanamine, what are the physical properties of chloride (1:1)
    1H-imidazole-4-ethylamine hydrochloride (1:1), this is an organic compound. Its physical properties are crucial and related to many applications.
    Looking at its properties, it is mostly white to off-white crystalline powder under normal conditions, fine and uniform, and this morphology is easy to store, transport and subsequent processing.
    In terms of melting point, it is about a specific numerical range. This property has an important indication of its stability and phase change under different temperature environments. In the chemical synthesis process, the grasp of melting point can help determine the reaction process and product purity.
    The solubility cannot be ignored either. It has a certain solubility in water and can be partially dissolved to form a uniform solution. However, the solubility may vary in some organic solvents. This property needs to be carefully considered during separation, purification and preparation of preparations.
    In terms of hygroscopicity, it has a certain degree of hygroscopicity. It may absorb water vapor in a humid environment, which affects its physical state and chemical stability. Therefore, it is necessary to pay attention to environmental dryness when storing.
    Its density is also an important physical parameter. Although the exact value varies depending on the measurement conditions, it is relatively stable under specific conditions. Density data is of great significance for operations involving mass and volume conversion, such as material ratio and preparation filling.
    The above physical properties are of indispensable value in many fields such as chemical production, drug research and development, and materials science, and both researchers and producers need to master them in detail.
    What are the common uses of 1H-imidazole-4-ethanamine, chloride (1:1)?
    1H-imidazole-4-ethylamine hydrochloride (1:1), this substance is commonly used and can be used in many fields. In the pharmaceutical and chemical industry, it is often used as a key intermediate to help synthesize a variety of drugs. Due to its unique chemical structure and activity, it can introduce specific groups into drug molecules, which affect the pharmacological properties of drugs, such as enhancing efficacy and improving pharmacokinetic properties.
    In the field of materials science, it also has applications. It can participate in the preparation of functional materials, such as by reacting with specific compounds to construct polymers or composites with special properties, such as adjusting the adsorption and conductivity of materials.
    In the field of biochemistry research, it also plays an important role. It can be used as a bioactive molecular model to help researchers explore complex chemical processes and interaction mechanisms in organisms. For example, simulating the binding of certain bioactive substances to receptors to gain a deeper understanding of the essence of related biological processes. In short, 1H-imidazole-4-ethylamine hydrochloride (1:1) has important value in many fields such as chemical industry, materials, and scientific research, and has a wide range of uses.
    1H-imidazole-4-ethanamine, what are the preparation methods of chloride (1:1)
    1H-imidazole-4-ethylamine hydrochloride (1:1), the method to prepare it is as follows.
    First, imidazole is used as the starting material. First, imidazole and acrylonitrile are added to obtain 4- (2-cyanoethyl) imidazole. After using Raney nickel as the catalyst, hydroreduction is performed in a hydrogen atmosphere, and cyanylation is formed into an amino group to obtain 1H-imidazole-4-ethylamine. After hydrochloric acid is used to form a salt, 1H-imidazole-4-ethylamine hydrochloride is obtained. The materials used in this way are commonly available, but the addition and reduction steps require controlled conditions and equipment to maintain yield and purity.
    Second, start with 4- (2-bromoethyl) imidazole. Heat the reaction with ammonia in a suitable solvent, such as ethanol. Bromine is replaced by ammonia to obtain 1H-imidazole-4-ethylamine. Then use hydrochloric acid to form 1H-imidazole-4-ethylamine hydrochloride. This step is simple, but 4- (2-bromoethyl) imidazole is not a widely used reagent, or need to be self-made, the cost may increase.
    Third, it is based on 4-imidazole formaldehyde. First, 4 - (hydroxymethyl) imidazole is reduced, and then reacts with halogenating agents such as sulfoxide chloride to obtain 4 - (halomethyl) imidazole. Then reacts with ammonia to introduce amino groups and finally forms a salt with hydrochloric acid. There are many steps in this way, and each step requires fine operation to keep the intermediate product pure in order to achieve the best yield.
    All methods to prepare 1H-imidazole-4-ethylamine hydrochloride have their own advantages and disadvantages. When actually making, when the material is available, the cost is weighed, and the equipment is not available, the appropriate method is selected.
    1H-imidazole-4-ethanamine, chloride (1:1) whether there is a safety risk
    1H-imidazole-4-ethylamine hydrochloride (1:1) This product is related to safety risks and needs to be reviewed in detail.
    When the nature of the product is unknown, the safety risk is unpredictable. 1H-imidazole-4-ethylamine hydrochloride (1:1), or chemically active, may come into contact with other products, and may cause unexpected changes. If it is not stored in accordance with appropriate regulations, such as temperature and humidity loss, or cause changes in properties, it may even cause danger.
    And when it is used, a little carelessness in operation, such as wrong dosage and environmental discomfort, may lead to safety risks. It may be corrosive, injuring the skin, damaging utensils; it may also be toxic, if inhaled or ingested, endangering health.
    And during the preparation process, if the properties of raw materials and reaction conditions are slightly poor, there will be hidden dangers. Therefore, if you want to use this product, you should check the classics carefully, clarify its physical and chemical properties, operate according to precise methods, and prepare good protection to ensure safety and safety, so that this product can be used without harm. In short, in 1H-imidazole-4-ethylamine hydrochloride (1:1), its safety risks must not be ignored, and it must be treated with caution.