1H-Imidazole, 4-(chloromethyl)-, monohydrochloride (9CI)

4- (chloromethyl) -1H -imidazole hydrochloride (9CI) is an organic compound. Its physical properties are unique, and it is often in the state of white to off-white crystalline powder at room temperature, which is easy to recognize by the naked eye. In terms of solubility, it has quite good solubility in water and can be uniformly dispersed, which is caused by the interaction between molecular structure and water molecules; in organic solvents, such as ethanol, it also has a certain solubility, but the degree of solubility varies in different solvents.
When it comes to melting point, it has been experimentally determined that the melting point of this compound is within a certain range, which is of great significance for its identification and purity judgment. The determination of the melting point can help chemists identify whether it is pure. If it contains impurities, the melting point often shifts and the melting range becomes wider.
Its stability is also an important physical property. Under normal conditions, this compound is relatively stable. In case of hot topics, open flames or strong oxidants, it may cause chemical reactions and cause changes in properties.
In addition, its density is also a specific value, which is related to the measurement and packaging design of materials storage, transportation and use. Understanding this physical property is of important guiding value in chemical production, scientific research experiments, etc., and can ensure accurate, safe and efficient operation.

The chemical synthesis of 4- (chloromethyl) -1H -imidazole monohydrochloride (9CI) has the following routes.
First, the corresponding imidazole derivative is used as the starting material. Find a suitable imidazole compound and introduce a chloromethyl group under appropriate reaction conditions. For example, using a specific base as the catalyst, in an organic solvent environment, the imidazole derivative is mixed with chloromethyl-containing reagents, such as chloromethylating reagents, such as chloromethyl ethers, etc., according to a specific stoichiometric ratio. In this reaction process, it is necessary to strictly control the reaction temperature and time. The temperature may need to be maintained in a certain range, such as between room temperature and moderate temperature rise. The reaction time may take several hours to ensure that the reaction proceeds in the direction of generating the target product.
Second, you can also start with the construction of an imidazole ring. Using nitrogenous and carbon-containing basic raw materials, such as some amines and aldones, the imidazole ring structure is first constructed through a multi-step reaction. First, the amines and aldones are condensed to form a specific intermediate product, and then the imidazole ring is formed through a cyclization reaction. Subsequently, chloromethyl is introduced at a specific position on the imidazole ring, that is, at the 4-position, using a suitable chloromethylation method. This process requires fine regulation of the conditions of each step of the reaction, including the proportion of reactants, reaction solvents, reaction temperature and reaction time, etc., to obtain the target product precursor. Finally, after reacting with hydrochloric acid, 4- (chloromethyl) -1H-imidazole monohydrochloride is formed.
Third, with the help of some special synthesis strategies. For example, the reaction path catalyzed by transition metals. Select specific transition metal catalysts, such as complexes of metals such as palladium and copper, with the assistance of ligands, to promote the coupling reaction of substrates containing appropriate functional groups, and then realize the synthesis of 4- (chloromethyl) -1H-imidazole monohydrochloride. This method requires accurate screening and determination of the type and dosage of catalysts and ligands, and detailed exploration of reaction conditions, such as the pH of the reaction system, reaction temperature, etc., in order to enable the reaction to proceed efficiently and selectively, in order to obtain higher yield and purity of the target product.

4- (chloromethyl) -1H-imidazole monohydrochloride (9CI), this substance has a wide range of uses. In the field of medicine, it is often used as an intermediate in organic synthesis to create new drugs. Through chemical reactions, it can be introduced into a specific molecular structure, endowing drugs with unique activities and properties, and helping to develop good drugs for treating various diseases.
In the field of materials science, it also has outstanding performance. It can participate in the preparation of special functional materials, such as materials with specific adsorption and catalytic properties. It is cleverly designed to combine with other substances to change the surface properties and structure of materials and expand the application scenarios of materials.
In chemical production, it is one of the important raw materials. It can be used to synthesize a variety of fine chemicals, such as special surfactants, additives, etc. These fine chemicals play a key role in all aspects of industrial production, or improve product performance, or optimize production processes.
It is a commonly used reagent in laboratories for scientific research and exploration. Scientists use it to carry out various chemical reaction research, explore new synthesis methods and reaction mechanisms, and provide assistance for knowledge expansion and technological innovation in the field of chemistry.

4- (chloromethyl) -1H -imidazole hydrochloride (9CI), the price of this product in the market is difficult to hide. The price fluctuation is affected by many factors.
First, the price of raw materials has a great impact. If the raw materials required for the synthesis of this imidazole hydrochloride are difficult to obtain, or the output changes due to weather, geography, personnel, etc., the price will rise and fall. If the price of raw materials is high, the price of finished products will also rise; if the price of raw materials falls, the price of finished products may fall.
Second, the preparation method is also the key. Sophisticated and efficient preparation technology can reduce its production cost, which in turn affects the market price. If there is a new way to increase productivity and reduce energy consumption, the price may change due to cost reduction.
Third, the market supply and demand trend, the price is very large. If the demand for imidazole hydrochloride in the fields of medicine and chemical industry increases greatly, but the supply is limited, the price will rise; on the contrary, if the demand is sluggish and the supply is excessive, the price may fall.
Fourth, the difference between manufacturers also makes the price different. Large factories rely on scale effect, brand advantage, or pricing is different; small factories or due to cost control, quality differences, etc., the price will also vary.
Looking at the market, the price of 4- (chloromethyl) -1H-imidazole hydrochloride (9CI) varies from time to time due to the intertwining of the above factors, ranging from a few yuan per gram to as many as tens of yuan per gram. To know the exact price, you must check the current market conditions and consult the suppliers.

4- (chloromethyl) -1H-imidazole monohydrochloride (9CI), this is a chemical substance. Its safety and toxicity are extremely important, and it is related to many practical application scenarios.
According to ancient books, this substance may have certain toxicity. Its chloromethyl structure is quite active, or it can chemically react with many biological macromolecules in organisms, such as proteins, nucleic acids, etc., thereby affecting the normal physiological functions of cells. When the human body comes into contact with this substance, or absorbs it through the skin, inhales it through the respiratory tract, or ingests it by mistake, it may lead to a series of adverse consequences.
If it is exposed through the skin, it may cause skin irritation, such as redness, swelling, itching, and pain. If accidentally splashed into the eyes, because of its corrosive, or cause serious damage to the eye tissue, and even affect vision. If inhaling dust or vapor containing this substance, or irritating the respiratory tract, causing cough, asthma, breathing difficulties and other symptoms. Long-term or large inhalation, or cause chronic damage to the lungs and other respiratory organs. As for accidental ingestion, or cause burns and ulcers to the mouth, throat, gastrointestinal tract and other digestive systems, affecting digestive function, serious or life-threatening.
However, when it comes to safety, if during operation, the relevant safety procedures can be strictly followed, appropriate protective measures can be taken, such as wearing protective gloves, goggles, masks, and operating in a well-ventilated place, the risk may be effectively controlled. Proper storage conditions are also essential. It should be placed in a cool, dry, and well-ventilated place, away from fire, heat, and oxidants, to prevent dangerous reactions.