1h Imidazole 4 Carboxamide 5 Hydroxy 1 Beta D Ribofuranosyl
quinoline thiophene imidazole thiazole

1H-Imidazole-4-carboxamide, 5-hydroxy-1-beta-D-ribofuranosyl-

    Specifications

    HS Code

    491869

    Chemical Formula C9H13N3O6
    Molar Mass 259.217 g/mol
    Appearance Solid
    Melting Point 199 - 202 °C
    Solubility In Water Soluble
    Pka 3.83 (for the carboxylic acid group)
    Isomerism Exists as a specific ribofuranosyl isomer
    Hydrophilicity Relatively hydrophilic due to multiple polar groups
    Functional Groups Hydroxy, carboxamide, imidazole, ribofuranosyl
    Chirality Chiral due to ribofuranosyl moiety

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    1H-Imidazole-4-carboxamide, what is the chemical structure of 5-hydroxy-1-beta-D-ribofuranosyl-?
    This is 5-hydroxy-1 - β - D-ribosyl-1H-imidazole-4-formamide, and its chemical structure is composed of several parts.
    The furan ribosyl part is based on the β-D-furan ribosyl configuration, and its carbon chain is a five-membered ring, and each carbon atom is numbered in sequence. One of the carbons is connected to the imidazole ring, which builds the key structure of the whole molecule.
    The imidazole ring as the core is a five-membered heterocycle containing two nitrogen atoms, which has aromatic properties. The nitrogen atom at the 1st position is covalently linked to the carbon at the 1st position of the furan ribosyl group, and the carbon at the 4th position is connected with a formamide group. This formamide group is composed of carbonyl and amino groups, which endows the molecule with specific reactivity and chemical properties.
    The presence of the 5-position hydroxyl group further enriches the molecular properties. Hydroxyl groups, as active functional groups, can participate in a variety of chemical reactions, such as esterification, oxidation, etc., which have a great impact on the metabolism of this compound in living organisms and its interactions with other substances.
    This compound has a unique structure and the synergy of various parts, which endows it with various chemical and biological functions. It is of great significance in the fields of medicinal chemistry, biochemistry and so on.
    1H-Imidazole-4-carboxamide, what are the main uses of 5-hydroxy-1-beta-D-ribofuranosyl-
    1H-imidazole-4-formamide, 5-hydroxy-1 - β - D-furan-ribosyl are useful in various fields.
    In the field of medicine, it is quite beneficial in the anti-viral industry. It can interfere with the synthesis of viral nucleic acid and prevent the growth of viruses, adding a powerful cornerstone to the research and development of antiviral drugs. And in the field of anti-tumor, it also shows its presence. Or it can inhibit the growth and proliferation of tumor cells by regulating cell metabolism and signal transduction pathways, providing new ideas for the creation of anti-cancer drugs.
    In terms of biochemical research, this substance is like a delicate key. Because its structure is similar to many important nucleotides in cells, it can be used as a tool to explore the mysteries of key processes such as cell metabolism, nucleic acid synthesis and repair, and help researchers clarify the fine mechanism of life activities.
    In addition, in the field of immune regulation, it also has potential utility. It may affect the body's immune system, mobilize the activity of the body's immune cells, improve the body's ability to resist foreign enemies, and open up new ways for the prevention and treatment of immune-related diseases.
    In summary, 1H-imidazole-4-formamide, 5-hydroxy-1 - β - D-furan ribosyl groups have considerable value and broad application prospects in many important fields such as pharmaceutical research and development, biochemical exploration, and immune regulation. It is an important substance worthy of in-depth study and exploration.
    1H-Imidazole-4-carboxamide, what are the physical properties of 5-hydroxy-1-beta-D-ribofuranosyl-
    1H-imidazole-4-formamide, 5-hydroxy-1 - β - D-furan-ribosyl This substance has the following physical properties:
    This substance is often in the state of white to off-white crystalline powder, and the texture is fine. Its melting point is quite high, about 170-175 ° C. At this temperature, the substance gradually melts from solid to liquid, which is one of its important physical characteristics.
    In terms of solubility, it can show certain solubility in water. Appropriate amount placed in water, stirred and other operations, partially soluble in water to form a uniform dispersion system, but not very soluble, solubility is limited. In common organic solvents such as ethanol, the solubility is relatively weak, only slightly soluble, showing a partial dispersion in the solvent, and it is difficult to form a homogeneous solution.
    Furthermore, the density of this substance is also one of its characteristics. Its density is about 1.8 - 2.0 g/cm ³. Compared with many common organic compounds, the density is within a certain range, reflecting the structural characteristics such as the compactness of its molecules.
    In addition, under normal temperature and pressure, the chemical properties of this substance are relatively stable, and it is not easy to spontaneously produce violent chemical reactions. When exposed to extreme conditions such as high temperature, strong acid, and strong alkali, its structure may change, causing chemical properties to change. Its appearance and physical properties provide an important basis for the identification and application of this substance, and are of great significance in many fields, such as the research and practice of medicinal chemistry and biochemistry.
    1H-Imidazole-4-carboxamide, what are the synthesis methods of 5-hydroxy-1-beta-D-ribofuranosyl-
    5-Hydroxy-1 - β - D-ribonyl-1H-imidazole-4-formamide, which is an important compound. Although the ancients did not directly state its synthesis method, it is obtained by many methods according to modern science.
    First, ribose derivatives are often used as starting materials. First, the ribose is modified by a specific reaction to make its hydroxyl group have suitable activity. Then, the condensation reaction is carried out with the imidazole-4-formamide-related precursor. This condensation needs to be carried out efficiently under the action of suitable solvents and catalysts. For example, an organic solvent is used as the medium, and a specific reagent of the catalyst amount is added to make the two fully react, and the target product is converted through multiple steps.
    Second, imidazole derivatives are also used as the starting point. The imidazole ring is modified, a suitable substituent is introduced, and then connected to the ribose derivative. In this process, the reaction conditions, such as temperature, reaction time, and the proportion of reactants, need to be precisely controlled. If the temperature is too high, the side reactions may increase; if the time is too short, the reaction may be incomplete.
    Every step of the synthesis requires fine operation. After the reaction is completed, the steps of separation and purification are still required. Or by chromatography, according to the product and impurities in the stationary phase and the mobile phase of the different partition coefficients, to achieve the purpose of separation; or by recrystallization method, by the product and the difference in the solubility of impurities at different temperatures, to obtain a pure 5 - hydroxy - 1 - β - D - ribosyl furan - 1H - imidazole - 4 - formamide.
    1H-Imidazole-4-carboxamide, 5-hydroxy-1-beta-D-ribofuranosyl- in which areas are more widely used
    5-Hydroxy-1 - β - D-nitrofuran-1H-imidazole-4-formamide, also known as ribavirin, is widely used in the fields of medicine and health, animal husbandry, and plant protection.
    In the field of medicine and health, it can be called an antiviral medicine. Ribavirin has significant inhibitory effect on many viruses, such as respiratory syncytial virus, influenza virus, and herpes simplex virus. In clinical practice, it is often used to treat viral pneumonia and bronchitis, and also has certain curative effects on Lassa fever and epidemic hemorrhagic fever. The mechanism of its anti-virus is to inhibit the synthesis of guanosine by inhibiting inosine monophosphate dehydrogenase, which in turn hinders the synthesis of viral nucleic acid.
    In the field of animal husbandry, ribavirin is also highly valued. The breeding industry is often affected by viruses. This drug can prevent and control a variety of animal viral diseases, such as Newcastle disease in poultry, avian influenza, and foot-and-mouth disease in livestock. It can effectively reduce animal morbidity and mortality, and ensure the economic benefits of the breeding industry.
    In the field of plant protection, ribavirin can also play a role. Some plant virus diseases seriously affect crop yield and quality, and it also has a certain inhibitory effect on some plant viruses, which helps to maintain the healthy growth of crops and ensure food safety and agricultural product quality.
    Ribavirin plays an important role in many fields related to antivirus, and with its unique antiviral properties, it provides strong protection for human health, animal husbandry and agricultural production.