1H-Imidazole-4-Carboxaldehyde

1H-imidazole-4-formaldehyde has a wide range of uses. In the field of medicine, it is often used as a key intermediate for the synthesis of a variety of drugs. The structure of Gainimidazole is common in many bioactive molecules. With its unique chemical properties, 1H-imidazole-4-formaldehyde can participate in the construction of drug molecules, such as the synthesis of antibacterial, antiviral and anti-tumor drugs, and can escort human health.
It also has its uses in the field of materials science. It can be used to prepare functional materials, because the aldehyde groups it contains are prone to react with other substances. Through chemical reactions, the surface of the material can be modified or modified to improve the properties of the material, such as enhancing the adsorption of the material and improving its compatibility with other substances, etc., so that the material can play a role in more fields.
Furthermore, in the field of organic synthesis, 1H-imidazole-4-formaldehyde is an important raw material. Chemists have designed and implemented various organic synthesis routes with their unique structures and reactivity, preparing many organic compounds with special structures and properties, which have contributed to the development of organic chemistry. Overall, 1H-imidazole-4-formaldehyde has important uses in many fields such as medicine, materials, and organic synthesis, and is of great significance for promoting the development of related fields.

1H-imidazole-4-formaldehyde, an organic compound, has unique physical properties. It is usually solid at room temperature and pressure, and it is often white to light yellow crystalline powder, which is easy to distinguish.
When it comes to the melting point, it is between 160-163 ° C, and the melting point is relatively high, reflecting the strong intermolecular force. Such a high melting point, in practical applications, when it involves heating treatment and other links, it needs to reach a specific temperature to cause it to melt.
In terms of solubility, 1H-imidazole-4-formaldehyde is soluble in a variety of organic solvents, such as methanol, ethanol, dichloromethane, etc. This solubility property is of great significance in the field of organic synthesis, so that it can participate in various chemical reactions in the corresponding solvent system as a reactant or intermediate, because the solvent can help it disperse evenly and promote the reaction to proceed fully.
However, its solubility in water is relatively limited, because the molecular structure of the compound contains a certain polar group, but the overall hydrophobic part accounts for a large proportion, making it difficult to dissolve in water with strong polarity.
In addition, 1H-imidazole-4-formaldehyde also has a certain volatility, but the volatility is weak. Although the evaporation rate is slow at room temperature, in a poorly ventilated and slightly higher temperature environment, its volatilization may increase. Therefore, when storing and using, it is necessary to pay attention to environmental ventilation to prevent its vapor accumulation.

The synthesis method of 1H-imidazole-4-formaldehyde is described in the ancient books, and is roughly as follows.
First, imidazole is used as the starting material and is prepared by formylation reaction. In a suitable reaction vessel, put an appropriate amount of imidazole, supplemented by a specific solvent, such as dichloromethane. The reaction system is cooled to an appropriate low temperature, such as about 0 ° C. Slowly add a formylating agent dropwise, such as a mixture of N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl). Add dropwise, gradually raise to room temperature, and continue to stir the reaction number. When the reaction is completed, it is suitable for alkali, such as sodium hydroxide solution, to neutralize the reaction solution. Then through the steps of extraction, separation and purification, such as extracting the product with an organic phase, and then by column chromatography or recrystallization, 1H-imidazole-4-formaldehyde can be obtained.
Second, 4-methylimidazole is used as the starting material, and the methyl group is first converted into an aldehyde group by oxidation reaction. In the reactor, take 4-methylimidazole and dissolve it in a suitable solvent, such as ethanol. Add an appropriate amount of oxidizing agent, such as a mixed system of manganese dioxide and sulfuric acid. Heat the reflux reaction for a certain period of time to make the oxidation reaction fully proceed. After the reaction is completed, solid impurities are filtered to remove, and the filtrate is distilled under reduced pressure to remove the solvent. The residue is further purified, such as by silica gel column chromatography, eluted with a suitable eluent, and the fraction containing the target product is collected. After concentration, 1H-imidazole-4-formaldehyde can be obtained.
Third, synthesized by cyclization reaction. The chain compound containing a suitable substituent is used as the raw material to form an imidazole ring in the molecule, and the aldehyde group is introduced at the same time. For example, a specific aminonitrile compound and a formaldehyde derivative are heated in a suitable solvent in the presence of a basic catalyst. The basic catalyst can be selected from potassium carbonate, etc., and the solvent can be selected from acetonitrile. During the reaction, cyclization and condensation occur in the molecule to generate 1H-imidazole-4-formaldehyde. After the reaction is completed, the target product can be obtained after separation and purification.

The price of 1H-imidazole-4-formaldehyde in the market is difficult to determine. This is due to different market conditions, and the price varies with many factors. The abundance of its raw materials, the difficulty of preparation, and the ebb and flow of demand are all reasons for price fluctuations.
Looking at the past, if the raw materials are widely available, the preparation method is simple and mature, and when the market is stable, the price may tend to be easy. However, if the raw materials are scarce, the preparation is difficult, or there are many applicants and few suppliers, the price will rise.
Also, the market conditions are different in different places, the east and the west are different, and the north and the south are different, and the price is also different. In places with prosperous trade and smooth transportation, the logistics is convenient, the cost may be reduced, and the price may be slightly lower; in remote areas, the transportation is difficult, the cost may increase, and the price may be slightly higher.
Although it is difficult to determine, it is common sense that if the market is stable, the price may hover within a certain range. To know the exact price, you need to ask the chemical material suppliers, or check the recent trading conditions on the market platform to get the clue of the actual price.

1H-imidazole-4-formaldehyde has a wide range of uses and has its traces in many fields.
In the field of medicinal chemistry, it is an important intermediate. In terms of the synthesis of specific drug molecules, by ingeniously reacting with other compounds, key structures can be built, and then substances with unique pharmacological activities can be shaped. For example, when developing drugs to treat certain inflammation or specific diseases, 1H-imidazole-4-formaldehyde can be used as a starting material to build a core skeleton through multi-step reactions, giving the drug the ability to target.
In the field of materials science, it is also useful. In the preparation of specific functional materials, it can be used as a structural modification unit. When synthesizing polymer materials with special optical and electrical properties, introducing them into the polymer chain can change the interaction between the molecules of the material, adjust the conductivity and fluorescence properties of the material, and open up the way for the preparation of new optoelectronic materials.
In the field of organic synthetic chemistry, it plays a key role. As a reaction substrate, it participates in many classical organic reactions. For example, condensation reactions with nucleophiles such as nitrogen and oxygen can generate a series of compounds with complex structures, providing a powerful tool for organic synthetic chemists to construct diverse molecular structures, greatly enriching the variety of organic compounds, and promoting the development of organic synthetic chemistry.