1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, mononitrate (9CI)

1H-imidazole, 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl), mononitrate (9CI), this is the name of the chemical substance. To know its chemical structure, it is necessary to interpret according to the naming rules.
"1H-imidazole", indicating that the compound contains an imidazole parent nucleus, and the hydrogen atom is attached to the nitrogen atom at the 1st position. "4,5-dihydro", indicating the hydrosaturation of the double bonds at the 4th and 5th positions of the imidazole ring. " 2 - (1,2,3,4-tetrahydro-1-naphthyl) ", indicating that the imidazole ring is connected to the 1,2,3,4-tetrahydro-1-naphthyl substituent at the 2nd position. The naphthalene ring of this naphthyl group has four hydrogen atoms added, and the connection check point is 1." Mononitrate "means that this compound forms a 1:1 salt with nitric acid.
In summary, the structure of this chemical substance is: with the imidazole ring as the core, the 4,5 positions are single bonds, and the 2 positions are connected to the 1,2,3,4-tetrahydro-1-naphthyl group. The whole is then salted with mononitrate. Thus, the chemical structures of 1H-imidazole, 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) and mononitrate (9CI) were obtained.

This is 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) -1H-imidazole mononitrate (9CI). Its physical properties are as follows:
This compound is often in a solid state at room temperature, but its specific appearance may vary depending on the purity and preparation process, or it is a white to off-white crystalline powder with fine texture and a certain luster under light.
Its melting point is an important physical constant, and the exact value is not yet known. The melting point can help to identify and determine the purity, and the melting point may fluctuate at different purity.
Solubility is also a key property. In water or with a certain solubility, it can interact with water molecules by hydrogen bonding and other interactions. However, the solubility varies greatly in organic solvents. In polar organic solvents such as ethanol, the solubility is better, but due to the principle of similar miscibility, the polarity of the two is similar; in non-polar organic solvents such as n-hexane, the solubility is poor or poor, because its structure has a certain polarity, and it interacts weakly with non-polar solvents.
In terms of density, although the exact value is unknown, it can be inferred from the structure and similar compounds. Its molecular structure contains aromatic rings and heterocycles, and the relative molecular weight is large, and the atomic arrangement between atoms is close, so the density may be greater than that of water. The specific value needs to be accurately determined by experiments.
This compound may have certain hygroscopicity, because its structure contains atomic groups such as nitrogen that can interact with water molecules. In a humid environment, or adsorbing moisture in the air causes self-deliquescence, which affects its stability and performance.

This chemical substance is called 1H-imidazole, 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) -, mononitrate (9CI), but its use in modern times is mostly related to pharmaceutical research and development.
According to the records of physicians, these chemicals may play a miraculous role in the healing of diseases. Or they can be used as active pharmaceutical ingredients to help create new types of medicines to deal with various diseases and pains. Viewer of ancient healers, tasted all kinds of herbs and gold stones as medicines to heal the people. Today's chemical substances are like ancient medicinal stones. After research and exploration, they may become a good prescription for the world.
In cardiovascular diseases, it can dilate blood vessels, make qi and blood flow smoothly, and make blood flow without stagnation, just like dredging a river to make water flow smoothly. Or in diseases of the nervous system, it can regulate nerve conduction, such as tuning the strings of the piano and making its voice harmonious, so that neural activity is normal. Or in the immune system, it can stimulate righteousness and enhance the power to resist external evil, just like strengthening the city defense, making it difficult for foreign enemies to invade.
Although the use of this substance has not been personally tested by the ancients, today's scientific research is like following the teachings of the ancient times, exploring the subtleties, hoping to cure diseases and diseases for the common people in the world, and benefit the world. It is also in line with the way of the ancient doctors who are kind and helpful to the world.

The synthesis method of 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) -1H-imidazole mononitrate (9CI) is studied in the field of organic synthesis. There are many methods, and the common ones are as follows.
First, the compound containing naphthyl group and imidazole derivatives are used as starting materials. First, the raw material containing naphthyl group is introduced into the halogen atom at a suitable position in the naphthalene ring through a specific reaction, such as halogenation reaction, to increase its reactivity. In the presence of a suitable base and solvent, the naphthalene group is connected to the imidazole group according to the nucleophilic substitution reaction mechanism to form 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthalene) -1H-imidazole. Then the obtained product is reacted with nitric acid or nitrate under specific conditions to form a mononitrate. In this process, factors such as the strength of the base, the polarity of the solvent, the reaction temperature and time all have a great influence on the reaction process and yield.
Second, the strategy of constructing an imidazole ring can be used. The imidazole ring was constructed by multi-step reaction with appropriate amines, carbonyl compounds, and aldides or ketones containing naphthyl groups as raw materials. The shilling amine condensed with the carbonyl compound, and then cyclized with the aldides or ketones containing naphthyl groups to form 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) -1H-imidazole parent structure. The target product was also obtained through nitrate steps. This path requires fine control of the reaction conditions at each step to ensure the selectivity of the reaction and the purity of the product.
Third, the catalytic synthesis method is also one way. Select specific catalysts, such as metal complex catalysts or enzyme catalysts, to promote the relevant reactions. Metal complex catalysts can change their electron cloud density and spatial configuration by coordinating with reactants, reduce the activation energy of the reaction, and speed up the reaction rate. Enzyme catalysts are highly specific and can efficiently catalyze reactions under mild conditions. This method requires screening suitable catalysts and optimizing catalytic reaction conditions to achieve ideal synthesis results.

This is 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) -1H-imidazole mononitrate (9CI), which is related to safety precautions, let me come one by one.
This item must be stored with caution. It needs to be stored in a cool, dry and well ventilated place, away from fires and heat sources. Because of its specific chemical properties, it may be dangerous to heat or open flames, so it is essential to control the temperature and humidity of the storage environment. If it is not stored properly, or its chemical structure changes, it will cause a safety accident.
When operating, you must also pay special attention. Operators should be professionally trained and act in strict accordance with the operating procedures. It is recommended to wear appropriate protective equipment during operation, such as protective glasses, to prevent this object from accidentally splashing into the eyes and causing damage to the eyes; wear protective gloves to avoid direct contact with the skin, because it may have irritating or corrosive effects on the skin; also wear a gas mask to prevent inhalation of its dust or volatile gases, which will have adverse effects on the respiratory tract.
Furthermore, during use, pay attention to environmental ventilation. If the ventilation is poor, the volatile gas of this object will accumulate in the space, and the concentration will gradually increase, or cause poisoning and other hazards, and high concentrations of gas or risk of explosion. Smoking and diet are strictly prohibited on the operation site to prevent this substance from mixing into the human body and endangering health.
When handling, the action must be gentle and careful to avoid damage to the packaging container. If the packaging is damaged, the leakage of this material may not only pollute the environment, but also it is quite difficult to deal with the leakage. If it is not careful, it will cause a safety hazard. If it leaks, the leaked contaminated area should be quickly isolated, and personnel should be restricted from entering and leaving. Emergency personnel need to wear protective equipment and breathing apparatus to clean up.
To sum up, the use, storage and handling of 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) -1H-imidazole mononitrate must be strictly operated in accordance with regulations, and always be vigilant to ensure safety.