1H-Imidazole, 2-isopropyl-1-methyl-5-nitro-

2-Isopropyl-1-methyl-5-nitro-1H-imidazole, this is an organic compound. Its use is quite extensive, in the field of medicine, or as a key intermediate in drug synthesis. Due to the specific structure of organic compounds, it is often endowed with unique biological activities. It can be used as a cornerstone for building complex drug molecules, assisting medical chemists to create new drugs with specific curative effects.
In the field of materials science, or participate in the research and development of new materials. For example, some materials containing imidazole structures may have unique electrical, optical or mechanical properties. The introduction of such compound structures may improve the material properties to meet the needs of different fields, such as electronic devices, optical materials, etc.
In the field of pesticides, it may also play an important role. Or it can be used as a synthetic raw material for pesticide active ingredients. After appropriate chemical modification and transformation, pesticide products with high-efficiency killing or inhibitory effects on pests can be created, which can help agricultural pest control and ensure crop yield and quality.
It is a commonly used reagent in chemical research for researchers to explore organic reaction mechanisms and develop new synthesis methods. Due to the particularity of its structure, it can participate in a variety of chemical reactions, providing important support for the development of organic synthetic chemistry, helping scientists expand the boundaries of chemical synthesis and create more novel compounds.

2-Isopropyl-1-methyl-5-nitro-1H-imidazole, which is white to pale yellow crystalline powder and stable under normal conditions. Its melting point is between 122-124 ° C, which makes it undergo phase transition under specific temperature conditions.
In terms of solubility, it is slightly soluble in water, but easily soluble in common organic solvents such as ethanol, dichloromethane, etc. This difference in solubility is due to the difference in its molecular structure and the forces between water molecules and organic solvent molecules. The nitro, methyl, isopropyl and other groups in its molecules together shape unique physical and chemical properties. < Br >
Because of its specific chemical structure, it is often used as a key intermediate in the field of organic synthesis. With these structural properties, it can be modified through a series of chemical reactions to construct more complex organic compounds, which are widely used in the preparation of fine chemical products such as medicines and pesticides.

2-Isopropyl-1-methyl-5-nitro-1H-imidazole, this is an organic compound, its chemical properties are very interesting, let me tell you one by one.
First of all, in its structure, the imidazole ring is the core part. The imidazole ring has aromatic properties, which endows the compound with certain stability. The electron cloud distribution of the aromatic system is special, so that the molecule can resist the intrusion of external chemical actions to a certain extent, and it is not prone to violent reactions such as ring opening.
2-position isopropyl, because isopropyl is the power supply subgroup, which affects the electron cloud density of the imidazole ring. The electron cloud density of the imidazole ring is increased by the electron carrier effect, especially in the ortho-paradigm. As a result, the activity of the compound changes in the electrophilic substitution reaction. Compared with imidazole itself, because of its increased electron cloud density, it is easier to react with electrophilic reagents, and the reaction check point is mostly inclined to the ortho-paradigm affected by the isopropyl electron carrier effect. The methyl group of
1 position, although its electron carrier capacity is slightly weaker than that of isopropyl, also contributes to the electron cloud of the imidazole ring. The existence of methyl groups changes the molecular space structure to a certain extent, and also affects the physical properties of the compound such as boiling point and melting point. Due to the addition of methyl groups, the intermolecular forces increase, so that the boiling point and melting point of the compound relatively increase. The nitro group at position 5 is a strong electron-absorbing group. The presence of nitro groups greatly reduces the electron cloud density of the imidazole ring. In contrast to the electron-absorbing effects of isopropyl and methyl groups, the electron-absorbing effect of nitro groups causes the electron cloud of the imidazole ring to shift towards the nitro group. This not only changes the electron cloud distribution of the compound, but also has a significant impact on its chemical activity. In the nucleophilic substitution reaction, the electron cloud density on the ring is reduced due to the nitro group, which is more likely to attract the attack of nucleophiles. At the same time, the presence of nitro groups also enhances the oxidation of the compound, because the nitro group can accept the reduction of electrons under appropriate conditions.
In addition, the solubility of the compound is also affected by each group. Isopropyl and methyl are hydrophobic groups, while nitro has a certain polarity. As a whole, its solubility in organic solvents is better than that in water. However, due to the polarity of nitro, its solubility in some polar organic solvents is also good.
In summary, the interaction of 2-isopropyl-1-methyl-5-nitro-1H-imidazoline groups shows unique chemical properties and may have potential application value in organic synthesis, medicinal chemistry and other fields.

To prepare 2-isopropyl-1-methyl-5-nitro-1H-imidazole, the following ancient method can be used.
First, it is necessary to select suitable starting materials, such as 1-methylimidazole as the base, because its structure is related to the target product, it can be used as the base. Place 1-methylimidazole in a suitable reaction vessel, which needs to be clean and temperature-resistant to prevent impurities from interfering with the reaction.
Then introduce isopropylation reagents, such as isopropyl halide. With the assistance of a suitable temperature and catalyst, the two can react with each other. Temperature control is extremely important. If it is too high, side reactions will proliferate, and if it is too low, the reaction will be slow. Usually use a moderate hot bath to keep the temperature constant in a certain range, and stir slowly to make the reactants mix evenly and promote the reaction to be efficient.
After isopropylation is completed, the intermediate product is obtained. It needs to be carefully separated and purified to remove its impurities before it can be used for subsequent use. Common extraction and distillation methods are used, which are selected according to the characteristics of the product.
Then proceed to the nitrification step. Prepare nitrification reagents, such as mixed acids (a mixture of nitric acid and sulfuric acid). Slow the purified intermediate product into the nitrification reagent. This process must be cautious because the nitrification reaction is intense. At the same time, the reaction temperature and time are tightly controlled, so as not to overreact and cause the product to decompose or become heterogeneous.
After the reaction is completed, the obtained crude product is purified to achieve high purity of 2-isopropyl-1-methyl-5-nitro-1H-imidazole. Or use the method of recrystallization to select a suitable solvent to crystallize the product and obtain a pure product.
During the whole synthesis process, each step requires fine operation and strict adherence to conditions to obtain the desired 2-isopropyl-1-methyl-5-nitro-1H-imidazole.

I don't know the price of 2-isopropyl-1-methyl-5-nitro-1H-imidazole in the market. The price of these chemical substances often varies for many reasons. If it is difficult to make, if its preparation requires complicated methods and rare materials, the price will be high; and if there is a state of supply and demand, there are many seekers and few suppliers, and the price will also increase, otherwise it will drop. And the difference between producers and quality can change the price. Or in the chemical industry, the field of medicinal materials, consult all merchants, or you can know the approximate price. However, I have not personally involved in the business situation, it is difficult to determine the range of its price. If you want to get an accurate price, you should go to the market in person to scrutinize the reports of various merchants, or study the recent prices on the trading platform of chemical materials, in order to obtain the approximate number.