1H-Imidazole-2-carboxylic acid

1H-imidazole-2-carboxylic acid, its chemical structure can be described as follows: This compound contains an imidazole ring, which is a five-membered heterocyclic ring composed of two nitrogen atoms and three carbon atoms. The two nitrogen atoms are in an interposition relationship. At position 2 of the imidazole ring, there is a carboxyl group (-COOH) connected.
The structure of the imidazole ring gives the compound its unique chemical properties. Its nitrogen atom has lone pairs of electrons and can participate in various chemical reactions, such as coordination reactions, to form complexes with metal ions. The presence of carboxyl groups makes the compound acidic and can neutralize with bases to form corresponding salts. The structure of 1H-imidazole-2-carboxylic acid is very important in the fields of organic synthesis and medicinal chemistry. Due to its special structure, it can be used as a key intermediate for the preparation of bioactive compounds. In drug development, its structure is often modified to obtain drugs with better efficacy and less side effects.

1H-imidazole-2-carboxylic acid, this is an organic compound. Its common physical properties, let me talk about them one by one.
Looking at its properties, it usually shows the appearance of white to light yellow crystalline powder, which is delicate and pure. This is due to the orderly arrangement of its molecular structure and the regular crystal form. The powder is easy to store and use, and it is quite convenient for many chemical operations.
When it comes to the melting point, it is about 280 ° C - 290 ° C. The melting point is higher, because of the strong intermolecular force. The hydrogen bonds and conjugate system in the molecule make the molecules closely connected, and high energy is required to break the lattice and melt it.
As for solubility, it is slightly soluble in water. Although there are carboxyl groups in the molecule that can form hydrogen bonds with water, the hydrophobicity of the imidazole ring limits its solubility in water. However, it is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc. In these organic solvents, the molecule and the solvent form a suitable interaction, so that it can be dissolved.
The density of 1H-imidazole-2-carboxylic acid is about 1.48 g/cm ³. This density value indicates the mass distribution of the molecule per unit volume, reflecting the compactness and relative mass size of the molecule.
Its stability is also worth mentioning, relatively stable under conventional conditions. When encountering strong oxidants, strong acids, strong bases and other substances, chemical reactions are prone to occur. Because the carboxyl groups and imidazole rings in the molecule have certain activity, they can participate in various organic reactions, such as esterification, amidation and other reactions.

1H-imidazole-2-carboxylic acid, this is a miraculous organic compound that has extraordinary applications in many fields.
In the field of medicine, its role is critical. Due to its unique chemical structure, it can be used as a key intermediate in drug synthesis. Through ingenious chemical reactions, compounds with specific pharmacological activities can be constructed, or have antibacterial effects, or have antiviral effects, or have potential value in the treatment of certain difficult diseases. It can be seen in the development path of many new drugs, helping medical researchers to explore more effective treatment options.
In the field of materials science, it also shows its unique charm. It can be used to prepare functional materials, such as some special polymer materials. It participates in the construction process of materials, giving them excellent properties such as good stability and special adsorption properties. These materials may play a role in separation membranes, sensors, etc., improving the performance and efficacy of related devices.
In the field of biochemical research, 1H-imidazole-2-carboxylic acids also play an important role. It can be used as a mimic of bioactive molecules to help researchers delve deeper into complex chemical reactions and biological processes in living organisms. Through the study of its properties and reactions, it is expected to reveal the mystery of life activities and contribute to the development of biological science.
In addition, it is also an indispensable reagent in the field of organic synthetic chemistry. With its active chemical properties, it can trigger a variety of organic reactions, providing the possibility for the synthesis of complex organic compounds with unique functions, and promoting organic synthetic chemistry to new heights.

There are many ways to synthesize 1H-imidazole-2-carboxylic acid, let me tell you one by one.
First, imidazole is used as the starting material. First, imidazole is reacted with appropriate carboxylic acid derivatives, such as acid chloride or acid anhydride, under suitable alkaline conditions. Basic substances can be selected from potassium carbonate, sodium carbonate, etc., in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). When reacting, pay attention to the control of temperature and reaction time, usually in the range of room temperature to moderate heating, ranging from a few hours to ten hours. In this process, the acyl group of the carboxylic acid derivative will replace the hydrogen atom at a specific position on the imidazole. After subsequent hydrolysis and other steps, 1H-imidazole-2-carboxylic acid can be obtained.
Second, it is prepared by cyclization reaction. Suitable precursors containing nitrogen and carbon are selected, and the target product is obtained by intramolecular cyclization. For example, some compounds containing nitrogen and carbonyl groups undergo cyclization and condensation under the action of catalysts. The catalysts involved can be specific metal salts or organic bases, the reaction environment or specific conditions such as anhydrous and oxygen-free conditions, and after complex chemical bond rearrangement and formation processes, the final 1H-imidazole-2-carboxylic acid is formed.
Third, it can be started from natural products. Some natural products contain fragments similar to 1H-imidazole-2-carboxylic acids in their structure, which are chemically modified and converted to gradually achieve the target structure. Through extraction and separation of natural products, and then a series of chemical reactions such as oxidation, reduction and substitution, the structure is precisely adjusted to obtain 1H-imidazole-2-carboxylic acids. Although the raw materials of this approach are natural, the steps may be cumbersome and require fine operation and separation technology.
In short, the synthesis methods of 1H-imidazole-2-carboxylic acids are diverse, and each has its own advantages and disadvantages. The appropriate method needs to be carefully selected according to actual needs and conditions.

1H-imidazole-2-carboxylic acid, this product is in the market, its price is uncertain, due to multiple factors intertwined. First, the quality is different, the pure one is expensive, and the miscellaneous one is cheap. Well-refined and rare impurities are needed by various industries, and the price is high; while those with more impurities and poor quality are inferior. Second, the trend of supply and demand, when there is a shortage of supply, the price will rise; if the supply exceeds the demand, the price will decline. For example, the pharmaceutical, chemical and other industries have strong demand for it, but the output is limited, and the price will rise; if the production capacity increases greatly, the market is full, and the price will fall. Third, the manufacturing cost, the price of raw materials, the simplicity of the process, and the amount of energy consumption all affect it. If the price of raw materials is high, the process is complicated, and the energy consumption is huge, the cost will be high, and the price will follow. Fourth, the difference in regions, different places, due to logistics, taxation, etc., the price is also different. Tongdu, with convenient transportation, the price may be stable; in remote places, the logistics is difficult, and the price may be slightly higher.
At present, the market price is between tens of yuan and hundreds of yuan per kilogram. However, this is only an approximate number, and the real-time price must be carefully checked by the market dynamics and consulted with the supplier. Purchasers should consider quality, price, after-sales, etc. comprehensively to obtain the best choice and gain an advantage in the business war.