1H-Imidazole-2-carboxaldehyde, 4-methyl-

4-Methyl-1H-imidazole-2-formaldehyde has a wide range of uses. In the field of medicine, it is often used as a key intermediate. In pharmaceutical chemistry, many bioactive molecular structures need to use such compounds containing specific functional groups as starting materials, and through a series of chemical reactions, complex and specific pharmacological molecules are constructed. For example, in the synthesis of some antibacterial and antiviral drugs, 4-methyl-1H-imidazole-2-formaldehyde plays an important starting cornerstone role.
It also has important applications in the field of materials science. When preparing functional polymer materials, it can be introduced into the polymer chain to give the material special properties. Because it contains active functional groups, it can polymerize with other monomers, thereby changing the physical and chemical properties of the material, such as improving the stability of the material, improving its adsorption performance to specific substances, etc., so that the material exhibits unique advantages in adsorption separation, catalytic support, etc.
In the field of organic synthetic chemistry, it is a commonly used synthetic block. Organic chemists can use it to react with various nucleophiles and electrophiles to form diverse carbon-carbon and carbon-heteroatom bonds, thereby synthesizing organic compounds with rich structures, providing an important material foundation for the development of organic synthetic chemistry, assisting scientists in exploring the synthesis paths and methods of more new organic compounds, and promoting the continuous development of organic chemistry.

4-Methyl-1H-pyrazole-2-formaldehyde is an organic compound with special physical properties. It is mostly in a crystalline solid state at room temperature. Due to the existence of van der Waals forces and hydrogen bonds between molecules, it is arranged in an orderly and solid state.
Looking at its melting point, it is about [X] ° C. The melting point is specific, and it is different due to the interaction between atoms and groups in the molecular structure. 4-Methyl-1H-pyrazole-2-formaldehyde molecules contain pyrazole rings and aldehyde groups. The pyrazole rings have certain rigidity, and aldehyde groups can participate in the formation of hydrogen bonds, strengthening the intermolecular forces, and the melting point is higher. < Br >
When it comes to the boiling point, it is about [X] ° C. The boiling point is restricted by the intermolecular forces. The molecules contain polar aldehyde groups, resulting in strong dipole-dipole interactions between molecules, and the pyrazole ring can also increase the intermolecular forces, so the boiling point is quite high.
In terms of solubility, 4-methyl-1H-pyrazole-2-formaldehyde has good solubility in organic solvents such as ethanol and dichloromethane. Both ethanol and dichloromethane are polar organic solvents. The polar aldehyde group of 4-methyl-1H-pyrazole-2-formaldehyde and the pyrazole ring can form hydrogen bonds or dipole-dipole interactions with the organic solvent molecules, and then dissolve them. However, in water, the solubility is not good, because the ability to form hydrogen bonds between water molecules and the compound molecules is limited, and the compound has an incomplete hydrophilic structure.
When the color of 4-methyl-1H-pyrazole-2-formaldehyde is pure, it may be a white to light yellow crystalline powder. Light color, because the molecular structure does not contain a large number of conjugated systems, the conjugated system often causes the compound to deepen in color. The physical properties of this compound have a profound impact on its synthesis, separation, purification and application. In the field of organic synthesis, suitable reaction conditions and separation methods can be selected according to its melting point, boiling point and solubility.

4-Methyl-1H-pyrrole-2-formaldehyde, this substance has many chemical properties. It has an aldehyde group, so it has typical aldehyde properties. If an oxidation reaction can occur, it can be oxidized to 4-methyl-1H-pyrrole-2-formic acid in case of weak oxidants, such as Torun reagent, and can be oxidized to 4-methyl-1H-pyrrole-2-formic acid, and at the same time form a silver mirror. This reaction is called a silver mirror reaction; in case of Feilin reagent, it can form a brick red cuprous oxide precipitation, because the aldehyde group has strong reductivity.
It can also undergo an addition reaction. The carbon and oxygen double bonds in the aldehyde group can be added to hydrocyanic acid to form compounds containing cyanide groups; under acid catalysis, acetal reactions can occur with alcohols to form acetal structures. Because the pyrrole ring is aromatic and has certain stability, the electron cloud distribution on the ring is uneven.
In the electrophilic substitution reaction, because the pyrrole ring is an electron-rich aromatic ring and the methyl group is the power supply group, the electron cloud density at the 2-position and 5-position is relatively higher, and the electrophilic reagents are easy to attack these two positions. If it reacts with halogenated reagents, halogen atoms can be introduced into the ring; it can also react with nitrifying reagents, sulfonating reagents, etc., and nitro, sulfonate groups and other substituents can be introduced at the corresponding positions.
In addition, the hydrogen on the pyrrole ring nitrogen atom of 4-methyl-1H-pyrrole-2-formaldehyde has a certain acidity, which can be taken away under the action of a strong base to generate the corresponding nitrogen negative ion. This negative ion can participate in the reaction as a nucleophilic reagent, and undergo nucleophilic substitution reaction with electrophilic reagents such as halogenated hydrocarbons, introducing new substituents on the nitrogen atom.

To prepare 4-methyl-1H-pyrazole-2-formonitrile, there are many methods, and there are several common methods.
One is to start with a suitable nitrogen-containing heterocyclic precursor. First, take a pyrazole derivative with a specific substituent and activate it in a basic environment with a strong base such as sodium hydride. Then, it meets with halogenated acetonitrile reagents such as chloroacetonitrile or bromoacetonitrile. These two react in a suitable organic solvent such as dimethylformamide (DMF) at moderate temperatures. The base can capture the hydrogen at a specific position of the pyrazole derivative, and the generated negative ions launch a nucleophilic attack on the carbon-halogen bond of halogenated acetonitrile, then form a carbon-carbon bond, and then obtain 4-methyl-1H-pyrazole-2-formonitrile.
Second, the pyrazole ring can be constructed from simple small molecules. Acetylacetone and formamidine are used as starting materials, and under the catalysis of acidic catalysts such as p-toluenesulfonic acid, the pyrazole ring is first condensed to form a pyrazole ring. After the pyrazole ring is formed, a cyano group is introduced. It can be reacted with cyanide reagents such as trimethylsilyl cyanide (TMSCN) in Lewis acid such as zinc chloride. Lewis acid activates the cyanide reagent to perform nucleophilic substitution at a specific position of the pyrazole ring, thereby introducing the cyanyl group at the 2-position to obtain the target product.
Third, halopyrazole is used as the substrate. If there is 4-methyl-halopyrazole, metal-catalyzed cyanation can be used. For example, a palladium catalyst, such as tetra (triphenylphosphine) palladium (0), is used in combination with cyanide reagents such as zinc cyanide. In organic solvents such as 1,4-dioxane, under heating conditions, palladium catalysts activate the carbon-halogen bond of halogenated pyrazoles, and cyano anions undergo nucleophilic substitution. Cyanyl groups are ingeniously introduced to obtain 4-methyl-1H-pyrazole-2-formonitrile.
All methods have advantages and disadvantages. In actual preparation, many factors such as the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product need to be weighed.

4-Methyl-1H-imidazole-2-acetonitrile, the price of this product in the market is difficult to determine. The price of this product often varies due to many reasons, such as the quality of the craftsmanship, the demand for supply, the size of the market, and the quality of the product.
If it is roughly, in the market of ordinary chemical raw materials, the price per kilogram may be around 100 gold. However, this is only an approximation. If the quality is good and pure, the price will increase. Or up to hundreds of gold per kilogram, depending on its purity and impurity control, the higher the purity, the higher the price.
If the demand of the market increases sharply, and the supply is not sufficient, the price will also rise. On the contrary, if the supply exceeds the demand, the price may drop. And in different regions and cities, the price is also different. In prosperous places and places with convenient transportation, the price may be different from that of other places, or it may be different due to the freight of freight, the cost of renting stores, etc.
In addition, the method and cost of production also have a great impact on the price. New and efficient methods can reduce the cost of production, and the price may change accordingly. In order to determine the price of this 4-methyl-1H-imidazole-2-acetonitrile, it is necessary to study the current market situation in detail and consult the merchants to obtain a more accurate number.