1H-Imidazole-1-acetic acid hydrochloride

1H-imidazole-1-acetic acid hydrochloride, this is an organic compound with unique chemical properties. Its properties are mostly white to off-white crystalline powders, which are relatively stable in the air, but may change when damp.
When it comes to solubility, it is easily soluble in water. Because the molecular structure contains polar groups, it can form hydrogen bonds with water molecules to help it disperse and dissolve. It also has a certain solubility in organic solvents, such as ethanol and methanol, but it has little solubility in non-polar solvents such as ether and benzene.
In terms of chemical activity, the imidazole ring in the molecule has electron-rich properties and is prone to electrophilic substitution reactions. The nitrogen atom on the ring can be used as an electron donor to react with electrophilic reagents to introduce new functional groups. This property has a wide range of uses in the field of organic synthesis and can be used to construct complex organic molecular structures.
In addition, its carboxyl group is partially acidic and can neutralize with bases to generate corresponding salts. Under appropriate conditions, carboxyl groups can also participate in esterification reactions and react with alcohols to form esters. The hydrochloric salt form makes it dissociable from hydrogen ions in aqueous solution, which is acidic and can react with basic substances.
In chemical reactions, 1H-imidazole-1-acetic acid hydrochloride is often used as an intermediate. With its special structure and reactivity, it participates in many organic synthesis steps, laying the foundation for the preparation of more complex compounds with specific functions.

1H-imidazole-1-acetate hydrochloride has a wide range of uses. In the field of medicine, it is a key organic synthesis intermediate and is indispensable in the preparation process of many drugs. For example, in the synthesis of some antibacterial drugs, it participates in the construction of drug molecular structures. With its unique chemical activity, it helps to form compounds with specific pharmacological activities, laying the foundation for the development and production of antibacterial drugs.
In the chemical industry, it is often used to prepare functional materials. Due to its structural properties, it can react with other compounds, thus endowing the material with special properties, such as improving the stability and solubility of the material. In the synthesis process of some polymer materials, it can participate in the polymerization reaction as a functional monomer to improve the comprehensive properties of the material.
In biochemical research, 1H-imidazole-1-acetate hydrochloride also has important uses. It can be used as a buffer or reagent to adjust the pH of the reaction system, or to participate in specific biochemical reactions, providing necessary conditions for the study of the structure and function of biomolecules. In protein crystallization experiments, a suitable buffer system is essential. 1H-imidazole-1-acetate hydrochloride can create a suitable environment for protein crystallization by virtue of its buffering properties, which helps to obtain high-quality protein crystals, and then help to analyze the three-dimensional structure of proteins.

The synthesis method of 1H-imidazole-1-acetic acid hydrochloride is as follows:
First take an appropriate amount of imidazole, place it in a reactor, and dissolve it in a suitable organic solvent. This organic solvent, when selected, has good solubility to imidazole and does not side-react with subsequent reactants, such as dichloromethane. Then, under stirring, slowly add the alkali metal salt solution of chloroacetic acid, and the alkali metal salt is usually sodium salt. This process requires temperature control. The temperature should be maintained within a certain range, between about 20 and 30 degrees Celsius, to prevent the reaction from being too dramatic or too slow. Add it dropwise and continue to stir for a few times to make the reaction fully proceed.
After the reaction is roughly completed, check the reaction progress by a suitable method, such as thin layer chromatography. After confirming that the reaction has reached the desired degree, the reaction solution is treated. First, adjust the pH value with dilute acid to the acidic range, about pH 3-4, so that the product can be salted out. Then, filter means to collect the filtered solid, which is the crude 1H-imidazole-1-acetic acid hydrochloride containing impurities.
The crude product is then purified. The crude product is recrystallized with an appropriate amount of alcohol solvent, alcohol is commonly selected ethanol, after heating and dissolving, filtered while hot to remove insoluble impurities, the filtrate is left to cool, and the crystals are precipitated. The crystals are collected by double filtration, washed with cold ethanol several times to remove surface impurities, and finally dried at a suitable temperature to obtain a pure 1H-imidazole-1-acetate hydrochloride product. In this way, it is the method of synthesizing 1H-imidazole-1-acetate hydrochloride.

1H-imidazole-1-acetic acid hydrochloride, the price of this product in the market is difficult to say in a word. Its price often varies with many factors.
In the past, the price of chemical products was mostly determined by the supply of raw materials, the difficulty of the production method and the prosperity of the market demand. If the raw materials are abundant and easy to obtain, the production method is simple and efficient, and the market demand is not too hot, then the price may be stable and low.
However, if the raw materials are scarce, it is difficult to find, and the preparation method is complicated, and when the market demand increases greatly, when the supply exceeds the demand, the price will rise. And the place where the market is traded is different from near and far, and the north and south are different, which also makes its price vary.
Furthermore, the business operation of merchants may have a strategy of small profits but quick turnover, or heavy quality and high price, which also makes the price of this product different. Therefore, if you want to know the exact market price of 1H-imidazole-1-acetate hydrochloride, you can get a more accurate price when you visit the chemical industry city, consult the industry, or search for recent business information.

1H-imidazole-1-acetate hydrochloride is a chemical substance. When storing and transporting, it is necessary to check the number.
It is quite sensitive to environmental conditions. This substance should be stored in a cool, dry and well-ventilated place. If placed in a high temperature environment, or cause its decomposition and deterioration, due to high temperature or trigger changes in its chemical structure. Similarly, humid environments are not advisable because they may absorb moisture, which in turn affects purity and quality, so moisture protection is essential.
Furthermore, this substance has certain chemical activity. When storing, it must not be co-stored with oxidizing or reducing substances to prevent violent chemical reactions and even cause danger. During transportation, the packaging must be firm to prevent leakage. If the package is damaged and leaks, not only may damage the surrounding items, but also the leakage may cause harm to the environment and human body.
It should also be noted that 1H-imidazole-1-acetate hydrochloride may be irritating to a certain extent. Those who operate, store and transport should take necessary protective measures, such as wearing appropriate protective gloves, glasses, etc., to avoid contact with skin and eyes to ensure personal safety. In short, when storing and transporting 1H-imidazole-1-acetate hydrochloride, relevant regulations and operating guidelines must be strictly followed to ensure its quality and safety.