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What is the chemical structure of 1h-imidazole, 1- [2- [ (4-chlorophenyl) methoxy] -2- (2,4-dichlorophenyl) ethyl] -
The chemical structure of 1- [2- [ (4-chlorophenyl) methoxy] -2 - (2,4-dichlorophenyl) ethyl] -1H-imidazole is as follows:
This compound is mainly composed of an imidazole ring, which is a five-membered heterocyclic ring containing two nitrogen atoms and has aromatic properties. At position 1 of the imidazole ring, a long chain substituent is connected. The substituent contains an ethyl group, and the second position of the ethyl group is connected with two different aryl groups, one of which is 2,4-dichlorophenyl and the other is 4-chlorophenyl connected by methoxy. < Br >
Such a structure makes the compound both the characteristics of an imidazole ring and the properties conferred by two chlorine-containing aryl groups. The presence of chlorine atoms on aryl groups can affect the electron cloud distribution, polarity and steric resistance of molecules due to the electronegativity of chlorine atoms. These structural characteristics may enable the compound to exhibit unique physical, chemical and biological activities in fields such as medicinal chemistry and materials science. In medicinal chemistry, its structure may interact with specific targets to exert pharmacological effects; in materials science, or its special structure may endow materials with specific properties.
What are the main uses of 1h-imidazole, 1- [2- [ (4-chlorophenyl) methoxy] -2- (2,4-dichlorophenyl) ethyl] -
1 - [2 - [ (4 - chlorophenyl) methoxy] - 2 - (2,4 - dichlorophenyl) ethyl] - 1H - imidazole, although this compound is not directly recorded in Tiangong Kaiwu, it is widely used in the chemical and pharmaceutical fields today.
In the chemical industry, it is often a key intermediate in organic synthesis. With its unique chemical structure, it can be derived from various chemical reactions to generate multi-functional compounds. For example, in the creation of new polymer materials, specific reactions are used to polymerize with other monomers to endow the materials with special properties, such as improved material stability, heat resistance, etc., which are widely used in plastics, fiber manufacturing and other industries, resulting in significant improvement in product quality and performance.
In the field of medicine, its activity and mechanism of interaction with biological targets have attracted great attention. Studies have shown that it is targeted to specific biological enzymes or receptors, or can be used to develop new drugs. For example, for some key targets of disease-related signaling pathways, a series of derivatives are chemically modified to screen compounds with high activity and low toxicity, providing an important direction for the development of disease treatment drugs. Like the development of anti-cancer drugs, by precisely targeting specific targets of cancer cells, it inhibits the proliferation and metastasis of cancer cells, while reducing damage to normal cells, providing a new opportunity to overcome cancer problems.
What are the physical properties of 1h-imidazole, 1- [2- [ (4-chlorophenyl) methoxy] -2- (2,4-dichlorophenyl) ethyl] -
1 - [2 - [ (4 - chlorophenyl) methoxy] - 2 - (2,4 - dichlorophenyl) ethyl] - 1H - imidazole This material has unique physicochemical properties. Its color state is often white to off-white crystalline powder, which is pure and delicate in appearance, just like the crystals of snow falling, and like the splendor of frost condensation.
When it comes to the melting point, the melting point is quite high, and it begins to melt between about 147-151 ° C, just like after a hot fire trial, it shows its firmness. The boiling point varies according to specific conditions, but due to normal considerations, it also requires a higher temperature to make it boil and transform.
In terms of solubility, this substance can dissolve quite well in organic solvents, such as dichloromethane and chloroform, just like fish in water, and it fuses seamlessly. In solvents such as ethanol and acetone, it also has a certain solubility. Although it is not as good as the first two, it can also merge with the solvent. However, in water, its solubility is not good, just like oil floating in water, each holding its own state.
In terms of density, it is about 1.36-1.42 g/³ cm. Although it is not as heavy as gold, it is also dense in texture and can be felt in the palm of your hand. < Br >
Its stability is acceptable under normal conditions. However, when encountering strong acids, strong bases, hot topics or strong oxidants, it is like an enemy, easy to react and cause structural changes. Under light, it may gradually change, so it needs to be properly preserved and should be stored in a cool, dry and dark place to prevent its sexual changes.
What is the preparation method of 1h-imidazole, 1- [2- [ (4-chlorophenyl) methoxy] -2- (2,4-dichlorophenyl) ethyl] -
To prepare 1 - [2 - [ (4 - chlorophenyl) methoxy] - 2 - (2,4 - dichlorophenyl) ethyl] - 1H - imidazole, the method is as follows:
First take an appropriate amount of (4 - chlorophenyl) chloromethane and (2,4 - dichlorophenyl) ethanol and place them in a clean reactor. Add an appropriate amount of basic catalyst, such as potassium carbonate, to the kettle to promote the reaction of the two. Control the temperature in a suitable range, such as 60 - 80 ° C, this temperature can make the reaction smooth and efficient. During the reaction, continue to stir to make the materials fully mixed. After several times of reaction, 2 - [ (4-chlorophenyl) methoxy] - 2 - (2,4-dichlorophenyl) ethanol can be obtained.
Then, place this product and imidazole in another reaction vessel, and then add an appropriate amount of dehydrating agent, such as dicyclohexyl carbodiimide (DCC), etc., and also control the temperature at a certain range, about 40-60 ° C. During the reaction process, the reaction process is closely monitored. After the reaction is complete, the impurities can be removed by separation and purification methods, such as column chromatography, to obtain pure 1- [2- [ (4-chlorophenyl) methoxy] -2- (2,4-dichlorophenyl) ethyl] -1H -imidazole. The whole preparation process requires strict adherence to operating standards and controlled reaction conditions to ensure the purity and yield of the product.
1H-imidazole, 1- [2- [ (4-chlorophenyl) methoxy] -2- (2,4-dichlorophenyl) ethyl] - What are the safety precautions
1 - [2 - [ (4 - chlorophenyl) methoxy] - 2 - (2,4 - dichlorophenyl) ethyl] - 1H - imidazole This drug involves many safety precautions and needs to be treated with caution.
The preparation, use and storage of this drug are strictly regulated. When preparing, it is necessary to precisely control the dosage of each raw material, the temperature and duration of the reaction. Because the raw materials are mostly chemical agents, there is a slight difference in the pool, or the reaction is abnormal, resulting in impurities, which not only affects the efficacy of the drug, but also brings unknown risks.
When using, the first thing is to strictly follow the doctor's instructions. Patients must not increase or decrease the dose without authorization, so as not to achieve the expected effect of the drug or cause adverse reactions. And during use, pay close attention to changes in their own body, such as whether there are allergies, whether the skin is itchy, rash, shortness of breath; whether there are any digestive system discomfort, such as nausea, vomiting, abdominal pain, etc. If such symptoms occur, stop taking the drug immediately and seek medical attention.
Storage should be placed in a dry, cool and well-ventilated place. Avoid high temperature and moisture to prevent the drug from deteriorating. Because the substance may be sensitive to light, it should be stored in a dark place, and it can be stored in a dark container such as a brown bottle.
Furthermore, this medicine may have an impact on the environment. Discarded drugs and packaging must not be discarded at will, and should be properly disposed of in accordance with relevant regulations to prevent pollution of the environment and harm to all living beings. Only by taking into account the above things can we ensure the safety of drug use and make the drug play its due effect without any worries.