1H-Benzimidazole-7-carboxylic acid

1H-benzimidazole-7-carboxylic acid, its chemical structure is formed by connecting the benzimidazole parent nucleus with a carboxyl group. Benzimidazole is a nitrogen-containing heterocyclic structure, which is fused by a benzene ring and an imidazole ring. In this fused structure, the two rings share two carbon atoms, and the carboxyl group (-COOH) is connected at the position numbered 7 on the basis of the benzimidazole parent nucleus.
Looking at its structure, the nitrogen atom of the benzimidazole part is alkaline and can form salts with acids. The carboxyl group is acidic and can react with bases. This acid-base property is of great significance for chemical reactions and pharmacological activities. The conjugated system in the structure of this substance gives it unique physical and chemical properties, such as certain stability and electron cloud distribution characteristics. The particularity of its structure makes it very interesting in the field of medicinal chemistry, or it is a potential active ingredient, and new drug molecules can be developed by modifying the structure. In materials science, this structure may be used to prepare functional materials due to its unique properties.
The chemical structure of 1H-benzimidazole-7-carboxylic acid, with benzimidazole as the core and carboxyl as an important substituent, gives it a variety of chemical properties and a wide range of application prospects.

1H-benzimidazole-7-carboxylic acid, an organic compound. It has a wide range of uses and is often used as a key intermediate in drug synthesis in the field of medicine. Many biologically active drug molecules rely on this to build core structures or be modified to achieve specific pharmacological effects, such as the development and preparation of anti-tumor, antiviral, and antibacterial drugs.
In the field of materials science, it can participate in the creation of functional materials. React with other substances or polymerize itself to form materials with unique properties, such as fluorescent materials, which are useful in optical devices, biological imaging, etc. < Br >
In the field of agricultural chemistry, it can be used as a raw material for the creation of pesticides to synthesize compounds with bactericidal, insecticidal or plant growth regulation effects, helping to improve crop yield and quality.
It can also be used in organic synthetic chemistry to provide a foundation for the construction of complex organic molecular structures. With its unique chemical properties, it participates in diverse chemical reactions and provides the possibility for the synthesis of novel organic compounds.

The synthesis methods of 1H-benzimidazole-7-carboxylic acid are various and exquisite. One of the common ones is to use o-phenylenediamine and oxalic acid as the starting materials. First, the o-phenylenediamine and oxalic acid are placed in the reaction vessel in an appropriate ratio, and an appropriate amount of solvent, such as ethanol and water, is added to help them mix evenly. Then, heat up to make the two slowly react. This process requires strict control of temperature and time. Usually, the reaction takes several hours within a certain temperature range to promote a sufficient reaction. After the reaction is completed, the crude 1H-benzimidazole-7-carboxylic acid can be obtained through cooling, filtration, washing, drying and other processes, and then fine operations such as recrystallization can be performed to improve the purity of the product. < Br >
Second, it can be started from o-nitroaniline. First, o-nitroaniline is converted into o-phenylenediamine through reduction reaction. Commonly used reducing agents include iron filings, sodium sulfide, etc. After obtaining o-phenylenediamine, the target product can also be prepared according to the above method of reacting with oxalic acid. Although this path has a slight increase in steps, it is convenient to obtain raw materials and has practical value.
Furthermore, using o-phenylenediamine and carbon dioxide as raw materials, under specific catalysts and suitable reaction conditions, 1H-benzimidazole-7-carboxylic acid can also be synthesized. This method is more green and environmentally friendly, but it requires strict reaction conditions. It is necessary to find an efficient catalyst and precisely control the temperature, pressure and other conditions to make the reaction proceed smoothly and obtain the ideal yield. All synthesis methods have their own advantages and disadvantages. In practical applications, careful choices should be made according to the availability of raw materials, cost, environmental protection and many other factors.

1H-benzimidazole-7-carboxylic acid, this physical property is also related to its shape, quality and properties. Its shape, under normal conditions, is solid, or in the form of powder, fine and uniform. Looking at its color, it is mostly white to off-white, pure and free of variegated stains.
In terms of its quality, the melting point is a key physical property. After various experimental investigations, its melting point is in a specific temperature range, which is the critical temperature range from solid to liquid. The number of melting points can be an important basis for identifying this substance and considering its purity. For those with high purity, the melting point is close to the theoretical value, and the melting range is narrow; if it contains impurities, the melting point may drop, and the melting range is also wide.
Its solubility varies in different solvents. In polar solvents such as water, it is slightly soluble or insoluble. The polarity of water interacts with the structure of 1H-benzimidazole-7-carboxylic acid, making it insoluble in water. However, in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it can have good solubility. This difference in solubility is of great significance in its extraction, separation and synthesis applications.
Another word about its chemistry, 1H-benzimidazole-7-carboxylic acid has the general properties of carboxylic acid. Because of its carboxyl group, it can neutralize with bases to generate corresponding salts and water. Under acid-catalyzed conditions, it can perform esterification reaction with alcohols to form ester compounds. And its benzimidazole ring also has certain reactivity and can participate in many electrophilic substitution reactions. It has a wide range of uses in the field of organic synthesis and can be used as an intermediate to derive a variety of compounds.

The price of 1H-benzimidazole-7-carboxylic acid in the market is difficult to determine. This is due to changes in price and depends on many reasons.
First, the trend of supply and demand is very critical. If there is a large number of people who need it, but the supply is small, the price will inevitably increase; conversely, if the supply exceeds the demand, the price may fall.
Second, the price of raw materials for this product also affects. The price of raw materials will increase, which will increase the cost of this product, and the price will also increase; the price of raw materials will decrease, and the cost will decrease, and the price may decrease.
Third, the process and technical level of making this product are also related to the price. The more complex the process, the more refined the technology, the higher the cost, and the higher the price.
Fourth, the state of competition in the market is also an important reason. The competition among the same industry is intense, in order to occupy the market share, or there may be a move to reduce its price; if the monopoly power in the market is strong, the price may be controllable at a high level.
As for the specific price, it is difficult to find details in ancient books such as "Tiangong Kaiwu". In today's city, its price changes frequently, or it can be consulted on the chemical raw material trading platform, related business websites, or negotiated with the factories and distributors that produce this product. Only then can the price be roughly in the range of tens to hundreds of yuan per kilogram, but this is not a fixed number, and it can be changed as the cause changes.