What is the chemical structure of 1H-benzimidazole, 6- (difluoromethoxy) -2- [[ (4-dimethoxy-2-pyridinyl) methyl] sulfinyl] -, sodium salt (1:1)

This is a chemical substance with the Chinese name 6- (difluoromethoxy) -2 - [ (3,4-dimethoxy-2-pyridyl) methyl] sulfinyl-1H-benzimidazole sodium (1:1). Its chemical structure is composed of several parts:

The benzimidazole ring is the core structure of this compound and is a nitrogen-containing double-ring heterocyclic ring. In 1H-benzimidazole, 1H indicates that the hydrogen atom is connected to a specific position of the benzimidazole ring. < Br >
6- (difluoromethoxy) indicates the introduction of a difluoromethoxy group at position 6 of the benzimidazole ring. This group is connected by one methoxy group and two fluorine atoms. The introduction of fluorine atoms can significantly change the physical and chemical properties of the compound, such as lipophilicity and stability.

2 - [ (3,4 - dimethoxy - 2 - pyridyl) methyl] sulfinyl group, which is connected to a complex side chain at position 2 of the benzimidazole ring. The side chain starts with a sulfinyl group, which is S (= O) -structure. One end of the sulfinyl group is connected to the benzimidazole ring, and the other end is connected to the [ (3,4-dimethoxy-2-pyridyl) methyl] group. This group contains a pyridine ring, each of the 3 and 4 positions of the pyridine ring is connected with a methoxy group, and the 2 position is connected to a methylene group and a sulfinyl group.

Finally, the compound forms a sodium salt, and the ratio of sodium to the above organic part is 1:1, indicating that the compound has an ionic structure. The sodium cation binds to the negatively charged organic anion, which affects the solubility, stability and biological activity of the compound.

What are the physical properties of 1H-benzimidazole, 6- (difluoromethoxy) -2- [[ (4-dimethoxy-2-pyridinyl) methyl] sulfinyl] -, sodium salt (1:1)

This is 6 - (difluoromethoxy) - 2 - [ (3,4 - dimethoxy - 2 - pyridyl) methyl] sulfinyl - 1H - benzimidazole sodium salt (1:1), and its physical properties are quite important. This substance is usually in solid form with good stability and can exist stably under normal conditions.

Looking at its solubility, it has a certain solubility in specific organic solvents, such as some polar organic solvents, but the solubility in water may vary depending on the characteristics of sodium salts. Its melting point and boiling point are also key properties. The melting point reflects the intermolecular forces and lattice stability, and the boiling point is related to the energy required for gasification. Both have a profound impact on the processing and application of this substance.

The density of this substance is related to its volume and mass in different environments, and is of great significance for storage and transportation. In addition, its appearance may be white or off-white, which can help to initially distinguish.

And its physical properties are closely related to the molecular structure. The core structure of benzimidazole, difluoromethoxy, pyridyl and other parts interact to shape these properties. When applying in chemical and pharmaceutical fields, these physical properties need to be carefully considered.

1H-benzimidazole, 6- (difluoromethoxy) -2- [[ (3, 4-dimethoxy-2-pyridinyl) methyl] sulfinyl] -, sodium salt (1:1) in which applications

1H-benzimidazole, 6- (difluoromethoxy) -2- [ (3,4-dimethoxy-2-pyridyl) methyl] sulfinyl -, sodium salt (1:1), this substance is widely used in the field of medicine. The key to treating patients and saving people is the art of Guanfu Medicine, and this compound is often used as an active ingredient in pharmaceutical preparations, or participates in drug synthesis, to play an effect in curing various diseases.

In the prevention and treatment of digestive system diseases, this drug may play a unique role. Gastrointestinal diseases are related to people's livelihood, and many pharmaceutical research and development are focused on this. If the compound is properly combined, it may improve gastrointestinal function and relieve discomfort such as stomach pain and bloating. Because the stomach is the foundation of human body transportation and transformation, regulating the stomach is the key to maintaining the health of the body.

In addition, in the field of antibacterial and anti-inflammatory, this sodium salt also has potential. Bacterial inflammation, harming the human body, invading the organs and meridians. The properties of this compound may inhibit the growth of bacteria, reduce inflammation, and help the human body resist external evil.

Furthermore, in the field of cardiovascular disease research, this substance may also emerge. The heart controls the bloodline, which is related to the operation of qi and blood throughout the body. Cardiovascular diseases occur frequently and endanger life. The compound may have a positive impact on the cardiovascular system, regulate blood lipids, blood pressure and other physiological indicators, and escort cardiovascular health.

In summary, 1H-benzimidazole, 6- (difluoromethoxy) -2- [ (3,4-dimethoxy-2-pyridyl) methyl] sulfinyl -, sodium salts (1:1) have potential application value in many fields of medicine, providing new opportunities and possibilities for relieving human pain and improving health.

What is the synthesis method of 1H-benzimidazole, 6- (difluoromethoxy) -2- [[ (3, 4-dimethoxy-2-pyridinyl) methyl] sulfinyl] -, sodium salt (1:1)

To prepare 1H-benzimidazole, 6- (difluoromethoxy) -2- [ (3,4-dimethoxy-2-pyridyl) methyl] sulfinyl-, sodium salt (1:1), the method is as follows:
First take appropriate starting materials, such as benzimidazole and pyridine compounds containing corresponding substituents. In an exquisite way, methoxy groups are introduced into the 3 and 4 positions of the pyridine compounds, and active groups that can be linked to benzimidazole can be constructed at the 2 positions. This may be fine-tuned according to the characteristics of the substrate and the reaction conditions by halogenation, nucleophilic substitution, etc. In the
benzimidazole part, a difluoromethoxy group is introduced at the 6th position. In this step, a suitable fluorination reagent and a methoxylation reagent need to be selected, or through a nucleophilic substitution reaction, under a specific solvent and catalyst, to achieve precise substitution.
Then, connect the two to form a key carbon-sulfur bond and construct a 2- [ (3,4-dimethoxy-2-pyridyl) methyl] sulfinyl structure. In this step, a sulfide reagent or an oxidizing reagent can be used to finely regulate the reaction process through multi-step conversion to ensure the correct formation of sulfinyl groups.
Finally, the alkali solution, such as sodium hydroxide solution, is neutralized by acid and alkali to form a sodium salt (1:1). The whole reaction process needs to pay attention to the control of temperature, pH, and reaction time to achieve high yield and high purity products. After each step of the reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to remove impurities and obtain a pure product, before the next step of the reaction or the final product can be obtained.

1H-benzimidazole, 6- (difluoromethoxy) -2- [ (4-dimethoxy-2-pyridinyl) methyl] sulfinyl] -, sodium salt (1:1) What are the precautions

This is a product called 1H-benzimidazole, 6- (difluoromethoxy) -2- [ (3,4-dimethoxy-2-pyridyl) methyl] sulfinyl -, sodium salt (1:1). When using this product, many matters need to be paid attention to.

First, it is related to storage. The properties of this product may vary depending on the environment. It should be placed in a dry, cool and well-ventilated place, away from fire and heat sources, to prevent deterioration. If it is not stored properly, it may cause its chemical structure to change and lose its original effect.

Second, it involves its operation. When operating, be sure to follow strict procedures. It is necessary to wear appropriate protective equipment, such as gloves, goggles, etc., due to direct contact or irritation to the skin and eyes. The operating environment should also be kept clean to avoid impurities from mixing and affecting its quality.

Third, it is related to the dosage. Dose control is the key. If it is too small or difficult to achieve the desired effect, too much may cause adverse reactions, or cause waste, or cause adverse effects on the surrounding environment.

Fourth, it is related to its compatibility. Before mixing with other substances, its compatibility must be checked in detail. If it is improperly mixed or causes chemical reactions, it will be ineffective in the light case, and dangerous in the serious case, such as explosion, generation of harmful gases, etc.

In short, the use of this object must be treated with caution in all aspects to ensure its safe and effective use.