1H-Benzimidazole-5-methanol(9CI)

1H-benzimidazole-5-methanol (9CI), its chemical structure is based on benzimidazole as the core structure. Benzimidazole is formed by fusing a benzene ring with an imidazole ring. In this structure, the imidazole ring contains two nitrogen atoms, showing a unique five-membered heterocyclic ring structure, while the benzene ring is a six-membered carbon ring. After fusing the two, the basic skeleton of benzimidazole is constructed.
In 1H-benzimidazole-5-methanol, "1H" means numbering and localization at the hydrogen atom of the imidazole ring. This numbering system follows the established rules in the chemical community to specify the specific position of the atom in the entire molecular structure. " 5-Methanol "indicates that a methanol group is connected to the 5th position of the benzimidazole ring system. The methanol group is composed of a methyl group (-CH 🥰) and a hydroxyl group (-OH), which are connected to the 5th position carbon atom of the benzimidazole ring by means of a carbon-carbon bond.
In this way, the complete chemical structure of 1H-benzimidazole-5-methanol is clearly presented. The interaction and spatial arrangement of different atoms and groups in this structure endow the compound with specific physical and chemical properties, and show potential applications in many fields such as organic synthesis and medicinal chemistry.

1H-benzimidazole-5-methanol (9CI) is an organic compound with special physical and chemical properties. Its appearance is often white to light yellow crystalline powder, which is conducive to discrimination and operation.
In terms of solubility, it has limited solubility in water, but it can be soluble in some organic solvents, such as ethanol and dichloromethane. This property is closely related to the molecular structure. The molecule contains polar groups and non-polar parts. The polar groups interact weakly with water molecules, resulting in poor water solubility. However, it can be miscible with organic solvents through intermolecular forces. When reacting and separating in the fields of organic synthesis and drug development, the solubility characteristic is the key.
The melting point of this compound is about 190-195 ° C. As an important physical constant of matter, the melting point reflects the strength of intermolecular forces. In this temperature range, the molecule obtains enough energy to overcome the interaction and changes from solid to liquid state. This property is of great significance for purity identification. If the melting point deviates greatly from the theoretical value, it may imply impurities.
1H-benzimidazole-5-methanol is chemically active, and its benzimidazole ring and methanol group can participate in various chemical reactions. Benzimidazole ring nitrogen atom can be used as nucleophilic reagent, which undergoes nucleophilic substitution reaction with halogenated hydrocarbons and other electrophilic reagents to form new carbon-nitrogen bonds, and derives rich structure compounds, which are used in the field of medicinal chemistry to construct active molecules; methanol groups can participate in esterification reactions and form ester compounds with carboxylic acids under the action of catalysts, expanding its application in organic synthesis and materials science.

1H-benzimidazole-5-methanol (9CI) has applications in many fields such as medicine, materials science and agriculture.
In the field of medicine, it is a key intermediate and can be used to synthesize compounds with diverse biological activities. Some compounds containing this structure have been found to have anti-cancer potential and can inhibit the proliferation and spread of tumor cells through specific mechanisms, opening up new paths for the research and development of anti-cancer drugs. In terms of antibacterial, the synthesized derivatives based on this can interfere with key physiological processes of bacteria, achieve antibacterial effect, or become a source of new antibacterial drugs.
In the field of materials science, it can be used as a functional material component. Due to its unique molecular structure and properties, it can improve the optical and electrical properties of materials. If it is introduced into polymer materials, it may endow the materials with special photoluminescence properties, which can be applied in the manufacture of optoelectronic devices such as optical sensors and Light Emitting Diodes to improve the performance and function of the devices.
In the agricultural field, it can participate in the synthesis of new pesticides. Some compounds based on 1H-benzimidazole-5-methanol have control effects on crop diseases and pests, or can affect the growth and development of pests and interfere with the metabolism of pathogens to ensure the healthy growth of crops. Compared with traditional pesticides, it may be more environmentally friendly and efficient, contributing to the sustainable development of agriculture.

There are various ways to synthesize 1H-benzimidazole-5-methanol (9CI). One is to use suitable starting materials and react in multiple steps.
In the first step, aromatic hydrocarbons with specific substituents can be selected to undergo cyclization reaction under delicate reaction conditions to build the basic skeleton of benzimidazole. For example, aromatic hydrocarbons containing amino and carboxyl groups, under the catalysis of acids or bases, are heated to promote intramolecular cyclization to form benzimidazole structures.
In the second step, hydroxymethyl groups are introduced at specific positions of the formed benzimidazole. This can be achieved by a nucleophilic substitution reaction. If benzimidazole reacts with halomethyl alcohol in the presence of a suitable solvent and base, the halogen atom leaves, and the hydroxymethyl group can access the target position to generate 1H-benzimidazole-5-methanol.
Or synthesize the intermediate product containing hydroxymethyl groups first, and then form a benzimidazole ring through a cyclization reaction. For example, a compound containing hydroxymethyl and o-phenylenediamine structures is cyclized under appropriate conditions to obtain the target product in one step. During the reaction, the reaction temperature, time, and the proportion of reactants need to be carefully adjusted, and the reaction solvent also needs to be carefully selected, so that the reaction can proceed efficiently in the direction of generating 1H-benzimidazole-5-methanol, and a product with high yield and purity can be obtained.

1H-benzimidazole-5-methanol (9CI), this product is in the market and has good prospects. Looking at today's chemical materials market, the pharmaceutical and chemical fields are booming, and the demand for characteristic organic compounds is increasing day by day. 1H-benzimidazole-5-methanol has a unique structure and has extraordinary potential in drug synthesis. Many studies have shown that it is a key intermediate, which can make anti-tumor and anti-viral drugs. The medical demand for such diseases is huge, which drives the market up.
Furthermore, in the field of materials science, with the development of electronic and optical materials, benzimidazole-containing structural compounds are favored. 1H-benzimidazole-5-methanol may participate in the preparation of high-performance materials, such as optoelectronic materials, to increase the specific properties of materials and promote its application in this field.
However, its market also has challenges. The synthesis process may be complex and expensive, limiting large-scale production. And the market competition is fierce, new synthesis methods and substitutes continue to emerge. To occupy the market, it is necessary to optimize the synthesis path, reduce costs and improve quality. It is also necessary to strengthen research and development and expand the scope of application, so as to be able to stand at the forefront of the market trend, enjoy the opportunities for development, and welcome the broad prospects in the future.