1H-Benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-, methyl ester

The chemical structure of 1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester is as follows:
This compound contains benzimidazole core structure, benzimidazole is formed by fusing benzene ring and imidazole ring. In the 1H-benzimidazole-5-carboxylic acid part, there is a hydrogen atom at position 1 of the benzimidazole ring, and a carboxyl group at position 5. The 2,3-dihydro-2-oxo moiety shows that the double bond between positions 2 and 3 on the imidazole ring is reduced to a single bond, and the oxygen atom at position 2 exists in the form of carbonyl. The last methyl ester moiety, that is, the carboxyl group at position 5, is esterified with methanol to form a methyl ester structure.
Its overall structure can be depicted as follows: first draw the basic framework of the benzimidazole ring, fused by a benzene ring and the imidazole ring in a specific way, then connect the carboxyl group-COOH at position 5, and then esterify the carboxyl group with methanol to form a - COOCH 🥰 structure, add a carbonyl group = O at position 2, and change the double bond between positions 2 and 3 to a single bond, and replenish the hydrogen atom at position 1. This is the chemical structure of 1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester.

1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester, this material has many physical properties. Its appearance is often a crystalline solid. Due to the specific atomic arrangement and interaction in the molecular structure, it has a specific crystal form, which can be seen under the microscope.
In terms of melting point, it is about [X] ° C. This value is determined by the intermolecular forces, including van der Waals forces, hydrogen bonds, etc. When heating up, the molecules are energized and vibrated. When the melting point is reached, these forces are overcome, and the substance changes from solid to liquid.
In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), because the molecules of the substance can form specific interactions with these organic solvent molecules, such as dipole-dipole interactions, etc., to help it disperse and dissolve; but it has low solubility in water, because its molecular hydrophobic part accounts for a large proportion, and its ability to form hydrogen bonds with water molecules is weak.
In terms of density, it is about [X] g/cm ³, depending on the molecular weight and the degree of molecular packing. If the molecular weight is large and the packing is close, the density is high.
In addition, the substance has a certain stability, and under normal environmental conditions, the chemical structure does not change significantly in a short time. However, under extreme conditions such as strong acid, strong base or high temperature, sensitive chemical bonds in the molecular structure, such as ester bonds, may undergo reactions such as fracture and hydrolysis, resulting in changes in their chemical properties.

1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester, this substance is widely used. In the field of medicinal chemistry, it is a key intermediate that can be chemically modified and structurally optimized to synthesize compounds with specific pharmacological activities. In the process of drug development for the treatment of diseases such as cancer and inflammation, it is used as a starting material to build complex and biologically active molecular structures through exquisite organic synthesis methods.
In the field of materials science, some materials based on this compound exhibit unique physical and chemical properties, such as specific optical and electrical properties, so it may be applied to the creation of new photoelectric materials, such as organic Light Emitting Diode (OLED), sensor materials and other fields, injecting new vitality into the development of materials science.
In the field of pesticide chemistry, after rational derivatization of this compound, it may be possible to obtain pesticide products with high insecticidal and bactericidal activities, which can help the prevention and control of agricultural pests and diseases, and ensure the healthy growth and harvest of crops.
It plays an important role in many fields, serving as a bridge between basic chemical research and practical applications, contributing an indispensable force to the advancement of science and technology in related fields.

To prepare 1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester, there are many methods. Common methods include using suitable starting materials and reacting in multiple steps.
First, you can take a compound containing a benzene ring and introduce an appropriate substituent under specific conditions to construct the basic skeleton of benzimidazole. For example, an aromatic derivative reacts with a nitrogen-containing reagent under the catalysis of an acid or base to form an imidazole ring. This process requires attention to the reaction temperature, time and reagent dosage to ensure that the reaction proceeds in the desired direction.
Furthermore, for the construction of the carboxylic acid methyl ester moiety, it can be obtained by esterification reaction with the corresponding carboxylic acid and methanol under the action of a catalyst at a suitable stage. The catalysts used are common, such as protonic acids such as sulfuric acid or solid acids such as p-toluenesulfonic acid, and also use enzyme-catalyzed green synthesis methods, which can obtain higher yields under milder conditions and are environmentally friendly.
Or, by selecting a suitable protecting group strategy. In the early stage of the reaction, some easily reactive groups are protected, and after the key steps are completed, the protecting groups are removed to obtain the target product. In this way, unnecessary side reactions can be avoided and product purity and yield can be improved.
During the preparation process, it is also necessary to use analytical methods such as thin layer chromatography, nuclear magnetic resonance, mass spectrometry, etc., to monitor the reaction process in real time to ensure that each step of the reaction achieves the expected effect, so as to successfully synthesize 1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester.

1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester There are many things to pay attention to when storing and transporting.
First, because of its chemical properties, it is quite sensitive to temperature and humidity. If the temperature is too high, it may cause changes in its chemical structure, which will damage the quality; if the humidity is too high, it may also cause deliquescence and other conditions. Therefore, when storing, it should be placed in a cool and dry place, and the temperature and humidity should be strictly controlled to ensure its stability.
Second, this substance may have a certain chemical activity and is easy to react with some substances. During transportation and storage, it is necessary to avoid co-storage and transportation with substances with strong oxidation and reduction, as well as strong acids and alkalis, to prevent dangerous chemical reactions, such as combustion and explosion.
Third, the packaging must be tight and reliable. The packaging materials must have good sealing and corrosion resistance to prevent leakage. And the packaging should be clearly marked with relevant warning labels and product information for identification and handling.
Fourth, the storage area should be well ventilated to prevent the accumulation of volatile gases and reduce safety risks. At the same time, the transportation process should be smooth, avoid violent vibration and collision, and prevent package damage.
In conclusion, when storing and transporting 1H-benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-methyl ester, it is necessary to fully consider its chemical properties and strictly follow relevant specifications and requirements to ensure personnel safety and product quality.