1H-Benzimidazole, 2-phenyl-

2-Phenyl-1H-benzimidazole, this substance is quite unique in its properties. Its shape is often crystalline, with a white to light yellow color, a pure texture, and a rather uniform appearance.
In terms of its melting point, it is about 282-286 ° C. Such a high melting point makes it stable in a solid state under normal circumstances. In terms of solubility, it is insoluble in water, just like oil and water. However, in some organic solvents, such as dimethylformamide and dimethylsulfoxide, it can be well dissolved, as if a wanderer has found a suitable place.
Furthermore, 2-phenyl-1H-benzimidazole has a certain thermal stability, and its structure and properties can be maintained in a certain temperature range under a heated environment, just like a person who is not surprised. However, when the temperature exceeds a specific limit, its structure will gradually change and even decompose, showing the inherent laws of matter under the action of heat.
In addition, it also has certain optical properties. Under specific wavelengths of light, it may exhibit fluorescence properties, just like a shimmer that quietly blooms in the dark. This property makes it potentially useful in fields such as optical materials.

2-Phenyl-1H-benzimidazole, this property belongs to the category of organic compounds. It has unique chemical properties and is a common substance in scientific research and industrial applications.
Looking at its physical properties, it is mostly white to light yellow crystalline powder at room temperature, which is conducive to storage and use. Its melting point is quite high, about 290-294 ° C. This characteristic makes the substance melt at higher temperatures and has good stability. And it is insoluble in water, and it is soluble in common organic solvents such as ethanol, chloroform, and dimethyl sulfoxide. Such solubility characteristics determine its application scenarios in different solvent systems.
When it comes to chemical properties, the structure of 2-phenyl-1H-benzimidazole contains a benzimidazole parent nucleus and a phenyl group. The benzimidazole parent nucleus endows it with a certain alkalinity, because the nitrogen atom has lone pairs of electrons, it can bind protons. Phenyl enhances the conjugate system of molecules, affecting its electron cloud distribution and reactivity.
The substance has significant chemical stability and is not prone to spontaneous chemical reactions under conventional conditions. However, under specific conditions, such as high temperature, strong acid-base or the presence of catalysts, it can participate in many chemical reactions. For example, it can be alkylated with halogenated hydrocarbons under appropriate conditions, introducing an alkyl group on the nitrogen atom of benzimidazole. This reaction broadens its chemical derivatization pathway and lays the foundation for the preparation of a variety of functional compounds.
In the field of organic synthesis, 2-phenyl-1H-benzimidazole is often used as a key intermediate. With its reactivity and structural properties, complex organic molecular structures can be constructed. In the field of materials science, due to its thermal stability and chemical stability, it can be used to prepare high-performance polymer materials and improve the thermal stability and mechanical properties of materials. In addition, in the field of medicinal chemistry, its derivatives exhibit a variety of biological activities, such as anti-tumor and antibacterial activities, providing potential directions for drug development.

2-Phenyl-1H-benzimidazole has a wide range of uses. In the field of medicine, it is often the key raw material for the creation of drugs. Because it has a specific chemical structure and biological activity, it can play a therapeutic effect on many diseases. For example, in the development of anti-parasitic drugs, by modifying the structure of 2-phenyl-1H-benzimidazole, the drug can improve the targeting and lethality of parasites, so as to achieve the purpose of effective deworming.
In the field of materials science, this compound also has important functions. It can be used to prepare polymer materials with unique functions because of its stable structure and specific optical and electrical properties. For example, by introducing it into polymers, the material can exhibit excellent fluorescence properties, which can be used in devices such as Light Emitting Diodes and fluorescence sensors.
Furthermore, in the field of organic synthesis chemistry, 2-phenyl-1H-benzimidazole often acts as a key intermediate. With its rich reaction check points, chemists can derive it through various chemical reactions, thereby constructing organic compounds with more complex and diverse structures, opening up a broad path for the creation and performance exploration of new substances. This compound plays an indispensable role in medicine, materials, organic synthesis and other fields, and has made great contributions to the development of related fields.

There are several common methods for the synthesis of 1H-benzimidazole-2-phenyl:
First, it uses o-phenylenediamine and benzoic acid as raw materials. Put o-phenylenediamine and benzoic acid in an appropriate proportion in the reaction vessel, and add an appropriate amount of catalyst, such as polyphosphoric acid. Raise the temperature to a suitable range, usually at 180-220 ° C, and the reaction lasts for several hours. In this process, the amino group of o-phenylenediamine and the carboxyl group of benzoic acid first condensate to form an amide, and then the amide is dehydrated and closed, and then 1H-benzimidazole-2-phenyl is obtained. The raw materials of this method are easy to obtain, the operation is relatively straight, but the reaction temperature is quite high, the equipment requirements are stricter, and there are many side reactions.
Second, o-nitroaniline and phenylacetic acid are used as starting materials. First, o-nitroaniline is reduced to o-phenylenediamine. The commonly used reducing agents are iron powder, sodium sulfide, etc. After obtaining o-phenylenediamine, it is reacted with phenylacetic acid under suitable conditions. The reaction can be carried out under acid catalysis, such as hydrochloric acid and sulfuric acid. The temperature is controlled at 150-180 ° C, and the synthesis of the target product is achieved through condensation and closed-loop steps. Although this approach is slightly complicated, the raw material cost is lower, and the yield may be considerable.
Third, o-phenylenediamine and benzoyl chloride are used In a basic environment, such as the presence of organic bases such as pyridine and triethylamine, o-phenylenediamine and benzoyl chloride are acylated to form an intermediate product. Subsequently, under the action of high temperature and appropriate dehydrating agent, the intermediate product is dehydrated and closed-loop to form 1H-benzimidazole-2-phenyl. This method has milder reaction conditions and faster reaction rate, but benzoyl chloride is corrosive, and careful protection is required during operation.
There are also 2-halo benzimidazole and phenylboronic acid synthesized by Suzuki coupling reaction. Under the action of palladium catalyst such as tetra (triphenylphosphine) palladium and base, the halogen atom of 2-halogenated benzimidazole is coupled with the boron group of phenylboronic acid to form 1H-benzimidazole-2-phenyl. This method has good selectivity and mild conditions, but the catalyst cost is high and the reaction equipment and operation requirements are fine.

Today, there is 1H-benzimidazole-2-phenyl. I will describe in detail the price of this product in the market. However, it is not easy to determine its price, and its price often changes for many reasons.
First, it is related to the purity of this product. If the purity is extremely high, it is almost flawless, and the price must be high; if it contains impurities, the price should drop.
Second, the supply and demand of the market is also the main reason. If there are many people who want it, and there are few suppliers, the price will rise; if the supply exceeds the demand, the price will tend to fall.
Third, the place of production and the method of production also have an impact. Different origins, due to differences in raw materials and processes, the price is also different.
According to my opinion, in the current market conditions, the price may be between tens of gold and hundreds of gold per catty. If it is of ordinary purity, and the market supply is still sufficient, the price may be low, about tens of gold per catty; if it is of excellent purity and there are many applicants, the price may be hundreds of gold per catty. However, this is only a rough estimate. The market conditions are ever-changing. The actual price must be consulted in detail with merchants in various cities, or the market situation at the trading place can be carefully inspected before the exact number can be obtained.