1H-Benzimidazole,2-(chloromethyl)-5-fluoro-(9CI)

This is 2 - (chloromethyl) -5 - fluoro - 1H - benzimidazole (9CI), which is an organic compound. This substance has unique chemical properties. In terms of physical properties, it is mostly solid at room temperature, but the specific properties are also related to purity. Its melting point, boiling point and other properties are affected by the presence of fluorine atoms and chloromethyl groups in the structure.
From the perspective of chemical activity, the presence of chloromethyl groups makes it highly reactive. The chlorine atom in chloromethyl groups is a good leaving group and can be replaced by nucleophiles in nucleophilic substitution reactions. If it interacts with nucleophiles such as alcohols and amines to form corresponding substitution products, this reaction is often used to construct new carbon-heteroatom bonds in organic synthesis.
The benzimidazole ring system also has certain reactivity, and nitrogen atoms can participate in the coordination reaction to form complexes with metal ions. The fluorine atom at the 5-position affects the electron cloud distribution of the molecule, which changes the electron cloud density of the benzimidazole ring, and affects the activity and check point selectivity of the electrophilic substitution reaction. The high electronegativity of the fluorine atom will cause the electron cloud of the benzimidazole ring to shift towards it, which will reduce the electron cloud density on the ring, and then affect the reaction activity and the reaction check point.
In addition, this compound may have potential applications in the field of medicinal chemistry. Due to its unique structure and reactivity, it may be used as a lead compound for structural modification and optimization to develop drugs with specific biological activities.

2 - (chloromethyl) - 5 - fluoro - 1H - benzimidazole (9CI), this compound has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of new anti-cancer drugs. Due to the unique electronic effect of fluorine atoms and the biological activity of benzimidazole structure, ingeniously modified and derived, anti-cancer agents with high targeting to specific cancer cells and precise inhibition of their proliferation and spread can be developed.
It also shows important value in the creation of pesticides. With its structural characteristics, pesticide components with high-efficiency poisoning or repelling effects on pests can be constructed, and due to the delicate molecular design, it is expected to achieve the goal of being more environmentally friendly and low-toxic to non-target organisms, and contribute to the development of green pesticides.
In the field of materials science, 2- (chloromethyl) -5-fluoro-1H-benzimidazole can participate in the synthesis of functional materials. By polymerizing or modifying with other monomers, the material is endowed with specific properties such as fluorescence and adsorption, and is applied to fluorescent detection materials or adsorption separation materials, which contributes to the innovative development of materials science.

The synthesis of 2 - (chloromethyl) - 5 - fluoro - 1H - benzimidazole (9CI) is an important research direction in the field of organic synthesis. To prepare this compound, the following steps can be followed:
Start with suitable starting materials, such as fluorine-containing benzene ring derivatives, and o-phenylenediamine compounds with appropriate substituents. In suitable reaction solvents, such as high boiling point and moderate polarity organic solvents, such as N, N - dimethylformamide (DMF), the two react with each other. During the reaction, the temperature should be controlled within a specific range, or under the state of heating and refluxing, so that the condensation reaction can fully occur to construct the basic skeleton of benzimidazole. During this process, the molar ratio of the reactants also needs to be precisely adjusted to ensure that the reaction advances in the desired direction.
After the condensation reaction is completed, the unreacted raw materials and by-products can be removed by appropriate separation and purification methods, such as column chromatography, to obtain a preliminary purified benzimidazole intermediate.
Then, for the obtained intermediate, to introduce chloromethyl chloride, a suitable chloromethyl methyl ether or a combination of triformaldehyde and hydrogen chloride can be selected. In another reaction system, the intermediate is reacted with chloromethylating reagents under the catalysis of catalysts such as anhydrous zinc chloride and other Lewis acids. This reaction requires strict control of reaction conditions, such as temperature and reaction time, to prevent excessive chloromethylation or other side reactions.
After the reaction is completed, a series of separation and purification operations, such as recrystallization and extraction, can obtain high-purity 2 - (chloromethyl) -5 - fluoro - 1H - benzimidazole products. The reaction progress and product purity of each step can be monitored and characterized by modern analytical methods such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and high performance liquid chromatography (HPLC) to ensure the effectiveness of the synthesis path and the quality of the product.

2 - (chloromethyl) - 5 - fluoro - 1H - benzimidazole (9CI) is an organic compound, and many matters need to be paid special attention during storage.
Bear the brunt, and temperature control is extremely critical. This compound is quite sensitive to temperature, and high temperature can easily cause it to decompose or deteriorate. Therefore, it should be stored in a cool place, and the temperature should be maintained between 15 and 25 degrees Celsius, which can minimize the rate of chemical change and ensure its stability.
Humidity is also a factor that cannot be ignored. Humid environment or reactions such as hydrolysis of compounds can damage their quality. It needs to be stored in a dry place. The relative humidity should be controlled at 40% to 60%. If necessary, a desiccant can be used to create a dry storage atmosphere.
Furthermore, the influence of light should not be underestimated. The compound may be sensitive to light, and the structure may be changed due to light-induced chemical reactions. Be sure to store in a dark place, and choose a brown bottle or light-shielding packaging material to avoid direct light.
In addition, the choice of storage container is crucial. Containers that are chemically stable and do not react with the compound should be selected. For example, glass containers are usually chemically stable, but it is necessary to pay attention to some special cases where the glass composition may react weakly with the compound; plastic containers should consider whether their material will interact with the compound to prevent dissolution of impurities or adsorption.
At the same time, this compound may have certain toxicity and danger. When storing, it should be separated from food, medicine, etc., and the storage area should be well ventilated to prevent the accumulation of volatile gases. At the same time, corresponding warning signs should be made to prevent personnel from accidentally touching and misusing. Only by paying attention to the above storage points can we ensure the quality and safety of 2- (chloromethyl) -5-fluoro-1H-benzimidazole (9CI) during storage.

2 - (chloromethyl) - 5 - fluoro - 1H - benzimidazole (9CI) This substance is related to safety risks and needs to be investigated in detail.
This chemical substance has a unique molecular structure, containing chloromethyl and fluorine atoms in the structure of benzimidazole. Chloromethyl has strong activity and is easily involved in reactions such as nucleophilic substitution, which may cause biological interaction with surrounding substances. The introduction of fluorine atoms changes the physical and chemical properties of compounds, affecting their stability, solubility and reactivity.
In terms of safety, the reactivity of chloromethyl may lead to dangerous reactions under improper conditions. In case of strong oxidants, strong alkalis, etc., or violent reactions, even the risk of fire and explosion. And organic compounds containing chlorine and fluorine are partially toxic. It is in the environment, or difficult to degrade, accumulates in organisms, enriches along the food chain, endangers ecological balance and biological health.
When handling this compound, proper protection is necessary. Experimenters need to wear protective clothing, goggles and gloves, and work in well-ventilated places to prevent their volatiles from inhaling and contacting the skin. When storing, it should be placed in a cool, dry and ventilated place to avoid mixing with contraindicated substances.
Overall, 2 - (chloromethyl) - 5 - fluoro - 1H - benzimidazole poses certain safety risks, and the operation and storage must be strictly regulated to ensure the safety of personnel and the environment.