1H-Benzimidazole-2-carboxylic acid, 5-bromo-

5-Bromo-1H-benzimidazole-2-carboxylic acid, this is an organic compound. Its physical properties, at room temperature or as a solid, due to the bromine atom, carboxyl group and benzimidazole ring in the molecule, it has a specific melting point, boiling point and solubility. Bromine atoms have a large relative atomic weight, or their melting point is higher than that of similar bromine-free substitutes. And because carboxyl groups can form hydrogen bonds, or slightly soluble in water, solubility in polar organic solvents or better.
In terms of chemical properties, carboxyl groups have high activity and can participate in many reactions. It can neutralize with bases to form corresponding carboxylate and water. This reaction is commonly found in acid-base neutralization systems. Under suitable conditions, carboxyl groups can be esterified with alcohols to form ester compounds, which is an important way to construct ester bonds in organic synthesis.
Furthermore, the benzimidazole ring endows it with special reactivity. The distribution of electron clouds on the ring makes the benzimidazole ring electrophilic substitution reaction, especially at specific positions on the ring, due to the localization effect of bromine atoms, it is more susceptible to electrophilic attack and substitution. This is an important means to modify the structure of the compound and introduce different functional groups.
In addition, the bromine atom in the molecule is also an active check point, which can be replaced by other functional groups through reactions such as nucleophilic substitution, thus realizing the structural diversity of the compound, providing many possibilities for organic synthesis and drug development. In conclusion, 5-bromo-1H-benzimidazole-2-carboxylic acids are rich in chemical properties and have important application value in organic synthesis and related fields.

5-Bromo-1H-benzimidazole-2-carboxylic acid, this compound has a wide range of uses. In the field of medicine, it is often used as a key intermediate. The genbenzimidazole structure plays an important role in many drug molecules. 5-bromo-1H-benzimidazole-2-carboxylic acid can be added to specific functional groups through a series of chemical reactions to construct molecules with specific pharmacological activities. For example, it can be used to develop anti-tumor drugs. By modifying the structure of the compound, it can precisely act on specific targets of tumor cells and interfere with the growth and proliferation of tumor cells.
It is also useful in the field of materials science. It is used in the synthesis of some organic optoelectronic materials. Because the benzimidazole ring in the structure imparts certain conjugate properties to the molecule, the introduction of bromine atoms can adjust the electron cloud distribution and spatial structure of the molecule. The synthesized materials may have unique optical and electrical properties, such as in organic Light Emitting Diode (OLED) materials, which may improve the luminous efficiency and stability of the materials.
In the field of pesticides, it can be used as an important raw material for the synthesis of new pesticides. With the modification of its structure, it is expected to create pesticides that have high inhibition or killing effect on specific pests or bacteria, and are relatively friendly to the environment, are not easy to remain, and reduce the negative impact on the ecological environment. In conclusion, 5-bromo-1H-benzimidazole-2-carboxylic acid has shown important value and application potential in many fields due to its unique chemical structure.

The preparation of 5-bromo-1H-benzimidazole-2-carboxylic acid requires specific steps and principles.
The selection of starting materials is crucial, and suitable halogenated benzene compounds are often used as the starting material. If p-bromoaniline is used as the starting material, it is first reacted with phthalic anhydride. This step is based on the chemical activity of the two. The carbonyl group of phthalic anhydride is electrophilic, and the amino group of p-bromoaniline is nucleophilic. The condensation reaction between the two occurs to form the intermediate product N - (4-bromophenyl) phthalimide. This reaction needs to be carried out under appropriate reaction conditions, such as suitable solvents (such as glacial acetic acid, etc.), and a certain temperature and reaction time can be controlled to ensure the smooth progress of the reaction.
Then, the generated N- (4-bromophenyl) phthalimide is further cyclized. Usually treated with strong dehydrating agents such as polyphosphoric acid, the cyclization reaction occurs in the molecule to form a 5-bromo-1H-benzimidazole-2-carboxylic acid precursor. This process is actually the process of intramolecular dehydration and cyclization. The presence of strong dehydrating agents prompts the reaction to move towards cyclization.
Finally, the generated precursor is hydrolyzed. Treated with a suitable alkali solution (such as sodium hydroxide solution, etc.), the specific group in the molecule is hydrolyzed and converted into 5-bromo-1H-benzimidazole-2-carboxylic acid. After hydrolysis is completed, acid (such as hydrochloric acid) is used for acidification to precipitate the target product 5-bromo-1H-benzimidazole-2-carboxylic acid. During this process, attention should be paid to controlling the reaction conditions to ensure the purity and yield of the product.
Or start from other starting materials, but the overall idea is to construct a benzimidazole ring and introduce bromine atoms and carboxylic groups. Each step needs to carefully control the reaction conditions to achieve the purpose of preparation.

I do not know the price range of 1H-benzimidazole-2-carboxylic acid and 5-bromine in the market. However, in books such as "Tiangong Kaiwu", there are few records about the price of this product. Because "Tiangong Kaiwu" is a book of various crafts and products, it is not written to record the price of this product. This 1H-benzimidazole-2-carboxylic acid, 5-bromine, or a product made by modern chemistry, has not been available in ancient times, and there is no price at that time. If you want to know its price today, you should consult the chemical material market, relevant chemical product suppliers, or check it on the chemical trading platform. The place varies from time to time, from quality to quality, and from quantity to quantity, so that the approximate price range can be obtained. Or chemical brokers, industry experts, can also say the approximate price. I regret that I cannot confirm the price range with the words of ancient books, but I hope this statement can help you find the price in today's market.

5-Bromo-1H-benzimidazole-2-carboxylic acid is related to safety and requires more attention.
Its chemical properties are lively, and care must be taken when handling. For storage, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its reaction with many substances, it must not be mixed with oxidants, reducing agents, acids, bases, etc. to prevent unexpected changes.
During operation, protective measures are indispensable. Be sure to wear appropriate protective equipment, such as protective glasses, to protect your eyes from harm; gas masks, to prevent harmful gases from invading your mouth and nose; corrosion-resistant protective clothing and gloves, to protect your body and hands from erosion. If you accidentally come into contact with this object, you should immediately dispose of it according to different situations. If it comes into contact with the skin, you need to rinse it with a large amount of flowing water quickly; if it enters the eyes, you should immediately lift the eyelids, rinse it with flowing water or normal saline, and seek medical attention in time.
During use, strict established procedures should be followed. The experimental site needs to have good ventilation and ventilation facilities to prevent the accumulation of harmful gases. The equipment used should also be clean and dry to avoid impurities interfering with its reaction and causing the risk of accidents. After taking it out, the residue should not be discarded at will, and should be properly disposed of according to regulations to avoid polluting the environment.
Furthermore, it is also extremely important to know its emergency response methods. In the event of a leakage accident, the personnel in the contaminated area should be quickly evacuated to a safe area, quarantined, and strictly restricted access. Emergency responders need to wear professional protective equipment to avoid exposing themselves to danger. For a small amount of leakage, clean equipment can be used to collect it in a suitable container; if the leakage is large, it should be built embankment or dug for containment, and adsorbed or absorbed with appropriate materials, and then treated harmlessly according to regulations. Only in this way can the operation be safe and the harm can be avoided.