1H-Benzimidazole, 2-bromo-5,6-dichloro-1-β-D-ribofuranosyl-

The chemical structure of 1H-benzimidazole, 2-bromo-5,6-dichloro-1 - β - D-furan ribosyl group is as follows according to the ancient text of "Tiangong Kaiwu":
This compound, the first view of benzimidazole base, its shape is like a ring, formed from a diazepine aromatic ring and a benzene ring, which is the core of the structure, such as the backbone of the house, and determines its fundamental shape.
At the second position of benzimidazole, followed by a bromine atom, bromine, and a halogen element, its reactivity, such as the warrior sword, gives this structure a different activity.
The 5th and 6th positions are connected to a chlorine atom, chlorine and halogen group, and dichlorine coexist, such as double protection, which affects the physical and chemical properties of the molecule.
Furthermore, the 1st position is connected to the β-D-furan ribosyl group, which is in the shape of a furan ring and has a unique three-dimensional configuration. The logo of β-D determines its configuration direction, like a compass pointing north, which is clear. Furan ribosyl is like a branch and leaf, connected to the trunk of benzimidazole, making the overall structure more abundant.
In this way, 2-bromo-5,6-dichloro-1 - β - D-furan ribosyl is connected to benzimidazole, and the parts interact to construct this unique chemical structure, which combines the stability of benzimidazole, the activity of halogen atoms and the characteristics of furan ribosyl. In the field of chemistry, it may have unique reactions and functions.

2-Bromo-5,6-dichloro-1 - β - D-furan-ribosyl-1H-benzimidazole is an organic compound whose physical properties are worthy of investigation.
The appearance of this compound is often in the solid form. Due to the arrangement and interaction of atoms in the molecule, it is endowed with a specific crystalline structure. Under the microscope, it can be seen as a crystal with a regular geometric shape. As for the color, it may vary depending on the conjugate system and the functional groups contained in the molecule, or it may be white or slightly yellow.
Melting point is one of the important physical properties. Intermolecular forces, hydrogen bonds and three-dimensional structures work together to determine its melting point. Generally speaking, its melting point is in a certain temperature range. During the heating process, when a specific temperature is reached, the lattice can be overcome, the crystal structure disintegrates, and then the solid state is transformed into a liquid state.
In terms of solubility, due to the polar groups contained in the molecule, it may have a certain solubility in polar solvents such as methanol and ethanol. Polar solvent molecules interact with the polar groups of the compound, and the compound is dispersed in the solvent through hydrogen bonds, dipole-dipole interactions, etc. However, in non-polar solvents such as n-hexane and benzene, the solubility may be very small, because the force between it and the non-polar solvent is weak.
Density is also one of the characteristics of the compound, depending on the molecular weight and the degree of molecular packing. The density value reflects the mass of the substance per unit volume, and this parameter is crucial when studying its mixing with other substances or behavior in a specific system.
In addition, the compound may have a certain degree of hygroscopicity, because some polar groups in the molecule can interact with water molecules in the air, adsorb water molecules, resulting in an increase in its mass, and its physical form may also change, such as agglomeration.
In summary, the physical properties of 2-bromo-5,6-dichloro-1 - β - D-furanribosyl-1H-benzimidazole are affected by many factors such as molecular structure and functional groups. In-depth understanding of it is of great significance in the fields of organic synthesis and drug development.

1H-benzimidazole, 2-bromo-5,6-dichloro-1 - β - D-furan-ribosyl is a substance with diverse uses.
In the field of pharmaceutical research, this substance may be used as a lead compound. Geinbenzimidazole compounds often have a wide range of biological activities, such as antibacterial, antiviral, anti-tumor, etc. This compound contains bromine, chlorine and furan-ribosyl groups, which may change the lipophilicity and spatial structure of the compound, affecting its interaction with biological targets. Researchers may hope to find new drugs with specific pharmacological activities and good pharmacological properties by evaluating their chemical modifications and biological activities. < Br >
In the field of organic synthesis, it can be used as a key intermediate. Due to its special structure, all kinds of functional groups can participate in many classical organic reactions, such as nucleophilic substitution, coupling reaction, etc. Chemists can use it as a starting material to design reaction routes to build more complex and functional organic molecules, expand the structural diversity of organic compounds, and provide a material basis for the development of materials science, medicinal chemistry and other fields.
In the field of materials science, it can be used to prepare special functional materials. If it is introduced into the main chain or side chain of a polymer material, with its unique electronic structure and spatial configuration, it may endow the material with special optical and electrical properties, such as fluorescence properties, semiconductor properties, etc., thus being applied to the preparation of materials such as Light Emitting Diodes and sensors.

The preparation methods of 2-bromo-5,6-dichloro-1 - β - D-furanyl-1H-benzimidazole are as follows:
First, the corresponding benzimidazole is used as the starting material, and bromine and chlorine atoms are introduced through halogenation reaction. First, benzimidazole is dissolved in a suitable organic solvent, such as dichloromethane or chloroform, and halogenated reagents containing bromine and chlorine are slowly added dropwise at low temperature, such as N-bromosuccinimide (NBS) and dichlorosulfoxide (SOCl ²). The reaction process needs to be closely monitored, and the reaction process can be tracked by thin-layer chromatography (TLC). After the reaction is complete, pure halogenated products can be obtained by conventional post-treatment methods such as extraction, washing, drying and column chromatography separation.
Second, ribose is used as the starting material, and it is properly protected first, such as protecting groups such as acetyl groups to protect hydroxyl groups. The protected ribose and halobenzimidazole undergo glycosylation under base catalysis. Select a strong base such as potassium carbonate or sodium hydride, heat and stir the reaction in an anhydrous organic solvent such as acetonitrile or DMF. After the reaction is completed, remove the protecting group, hydrolyze under acidic or alkaline conditions, and then separate and purify to obtain the target product.
Third, a benzimidazole ring can also be constructed by a multi-step reaction. First, a suitable o-phenylenediamine derivative is condensed with a halogenated furan ribose derivative under suitable conditions to form an intermediate. After that, the intermediate is cyclized, such as under the action of dehydrating agents such as concentrated sulfuric acid or polyphosphoric acid, to form a benzimidazole ring. Finally, according to the needs, the ring is halogenated to obtain 2-bromo-5,6-dichloro-1 - β - D-ribose-furan-1H-benzimidazole. Careful separation and purification are required after each step of the reaction to ensure the purity and yield of the product.

There are many chemical reactions related to 2-bromo-5,6-dichloro-1 - β - D-furanosyl-1H-benzimidazole, and they are of great significance in various synthesis and transformation.
In the halogenation reaction, the bromine atom of this compound can be used as the leaving group of the nucleophilic substitution reaction. For example, in the case of nucleophilic reagents such as alkoxides and amines, nucleophilic substitution will occur, forming new C-O bonds or C-N bonds, resulting in ether or amine derivatives.
In the glycosylation reaction, its furan ribosyl group can participate in the glycosyl transfer reaction. When combined with suitable receptor molecules and under the action of catalysts, new glycoside bonds can be constructed to synthesize complex glycoconjugates, which are widely used in the fields of pharmaceutical chemistry and total synthesis of natural products.
Furthermore, the benzimidazole ring system is also reactive. Electrophilic substitution reactions can be carried out on the ring. Due to the distribution of electron clouds on the ring, there will be selective substitution at specific positions. For example, under suitable conditions, other functional groups, such as alkyl and aryl groups, can be introduced into the benzimidazole ring to enrich the structure of compounds and expand their properties and uses.
In addition, reduction reactions are also worth mentioning. Some functional groups in molecules, such as halogen atoms, can be reduced and removed under the action of specific reducing agents, or converted into other functional groups, providing a way to adjust the structure and activity of compounds.
This kind of chemical reaction, like the ancient alchemist's method of preparing medicinal pills, has its own ingenuity. By finely manipulating the reaction conditions, the proportion of reactants, etc., the precise shaping of the compound structure can be achieved, just like a skilled craftsman carving beautiful jade, making products that meet different needs, paving the way for organic synthesis, drug research and development and other fields, opening the door to the world of new compounds and new materials.