1H-Benzimidazole,2,5-dimethyl-(9CI)

2,5-Dimethyl-1H-benzimidazole (1H + -Benzimidazole, 2,5-dimethyl - (9CI)) is one of the organic compounds, which has its uses and research value in many fields. The following is a detailed description of its physical properties:
Looking at its appearance, at room temperature and pressure, 2,5-dimethyl-1H-benzimidazole is usually in the state of white to light yellow crystalline powder, with fine texture. Such appearance characteristics are easy to identify and are consistent with the morphology of many organic compounds.
As for the melting point, it is about 180-185 ° C. The melting point is an important physical constant of a substance. This temperature range means that when the ambient temperature rises to a specific range, the compound melts from a solid state to a liquid state. Its melting point characteristics are related to the intermolecular forces. The lattice structure created by the intermolecular forces of the compound disintegrates at 180-185 ° C, and then undergoes a phase transition.
Its solubility is also a key property. The compound is slightly soluble in water, but soluble in common organic solvents such as ethanol and dichloromethane. This solubility is due to its molecular structure, the presence of benzimidazole ring and methyl group, which makes the molecule have a certain hydrophobicity, so the solubility in water is not good; while the molecular structure and force form of organic solvents are more compatible with 2,5-dimethyl-1H-benzimidazole, thus showing good solubility.
The density of 2,5-dimethyl-1H-benzimidazole is about 1.2 g/cm ³. The density is used as the mass per unit volume of a substance, and this value reflects the degree of compaction of the molecules of the compound. The density of 1.2 g/cm ³ indicates that the molecules are arranged in space with a specific compactness, which is also closely related to the molecular structure and interactions.
In addition, the compound is stable at room temperature and pressure. When it encounters strong oxidizing agents, strong acids, strong bases and other substances, or a chemical reaction occurs, resulting in structural changes, which in turn affect its physical properties. When storing and using, it is necessary to choose appropriate conditions according to these properties to ensure its stable properties and effective use.

2,5-dimethyl-1H-benzimidazole (9CI) is an organic compound with unique chemical properties. Its appearance is often in solid form, and physical properties such as melting and boiling point are of great significance to chemical production. From the perspective of structure, it contains benzimidazole parent nucleus, and dimethyl is substituted in a specific position, which affects its electron cloud distribution and spatial structure, and then affects its chemical activity.
This compound has a certain acidity and alkalinity. Because the benzimidazole ring contains nitrogen atoms, it can provide lone pairs of electrons, is weakly basic, and can react with acids to form salts. Under suitable conditions, it can participate in electrophilic substitution reactions. The conjugated system of benzene ring and imidazole ring makes the electron cloud density on the ring change, and the specific position is more susceptible to the attack of electrophilic reagents, such as halogenation, nitrification, sulfonation and other reactions, which is of great significance for the preparation of functionalized derivatives.
2,5-dimethyl-1H-benzimidazole also has certain coordination ability. Nitrogen atoms can be used as ligands to coordinate with metal ions to form metal complexes. These complexes are widely used in the fields of catalysis and materials science. For example, some metal complexes can be used as catalysts to improve the efficiency of specific chemical reactions. In addition, it may have potential biological activity in the field of medicinal chemistry and can be used as a lead compound. After structural modification and optimization, drugs with specific pharmacological effects can be developed.

What are the common uses of 2H-benzimidazole, 2,5-dimethyl- (9CI)? This is a question related to chemical substances. Although "Tiangong Kaiwu" is an ancient scientific and technological masterpiece in our country, the book may not cover the specific use of this chemical substance. However, in the style of ancient classical Chinese, you can try to extrapolate it.
2H-benzimidazole compounds have unique structures, or they are endowed with specific chemical properties due to the substitution of dimethyl. In ancient times, although there was no modern fine chemical understanding, analogical reasoning was available. It may be used in some dyeing processes because of its structure or can be combined with fabrics to show a specific color. Or it has potential uses in medicine. The ancients made unremitting exploration of the medicinal uses of natural and synthetic substances. Such compounds with stable structures may have certain antibacterial and anti-inflammatory effects, and can be used to treat simple injuries.
Or in some processes as a prototype of catalysts. Although the ancients did not know the principle of catalysis, in actual operation, they found that this substance can change some reaction processes, accelerate the formation of products, and thus be used in the preparation of specific materials. Although there is no exact ancient book documenting its use, it can be inferred from the logic of chemical structure and the development of ancient processes.

There are currently 2,5-dimethyl-1H-benzimidazole (9CI), and I would like to know the method of its synthesis. There are many different synthesis methods, and the following is described in detail by you.
First, the starting materials are o-phenylenediamine and acetylacetone. The two interact under suitable reaction conditions, such as at a certain temperature and in the presence of a catalyst. First, the amino group of o-phenylenediamine undergoes a condensation reaction with the carbonyl group of acetylacetone, and the basic structure of benzimidazole is gradually constructed. During the reaction process, the temperature, reaction time and the ratio of raw materials need to be carefully adjusted. If the temperature is too high, or the side reaction increases, the product is impure; if the temperature is too low, the reaction rate will be slow and the time-consuming will be too long. Only by properly controlling the proportion of raw materials can the reaction proceed smoothly in the direction of generating the target product.
Second, 2-methyl-5-nitroaniline can also be used as the starting material. It is first reduced to convert the nitro group into an amino group to obtain 2-methyl-5-aminoaniline. Subsequently, with suitable carbonyl compounds, such as acetaldehyde, under the action of an acidic catalyst, a cyclization reaction occurs to form a benzimidazole ring. In this process, the choice of conditions for the reduction reaction is very critical. The type and amount of catalyst, the pH of the reaction medium, etc., will all affect the efficiency of the reaction and the purity of the product. During the cyclization reaction, the strength and amount of acidic catalyst should also be carefully considered to promote the efficient and selective generation of 2,5-dimethyl-1H-benzimidazole.
Third, the coupling cyclization reaction can also be carried out by using appropriate halogenated aromatics and nitrogen-containing heterocyclic compounds as raw materials under the action of metal catalysts and ligands. This method requires more stringent reaction conditions, and the activity of metal catalysts, the structure and properties of ligands need to be carefully screened. Factors such as the type and dosage of solvents and bases in the reaction system will also significantly affect the process of the reaction and the yield and purity of the product. Careful experimental investigation is required to determine the optimal reaction conditions and successfully synthesize 2,5-dimethyl-1H-benzimidazole.

2,5-Dimethyl-1H-benzimidazole (9CI) is useful in many fields. In the field of Guanfu Chemical Industry, it is often used as an intermediate in organic synthesis. Its structure is unique, and various organic compounds can be derived through various chemical reactions. It has played an important role in the preparation of fine chemicals.
Looking at the realm of medicine again, it may have potential biological activity. Research or find that it can interact with specific targets in organisms, which is helpful for the treatment or prevention of certain diseases. Although it may not be used maturely, the research prospect is promising.
In the field of materials science, it is also quite eye-catching. Due to its structural properties, it can be applied to the preparation of functional materials, such as materials with special optical and electrical properties, opening up new avenues for material research and development.
In the genus of analytical chemistry, it can be used as an analytical reagent. Due to its specific chemical properties, it can produce characteristic reactions with certain substances, which is helpful for qualitative and quantitative analysis of substances, and improves the accuracy and reliability of analysis.
All in all, 2,5-dimethyl-1H-benzimidazole (9CI) has shown its promise in many fields such as chemical industry, medicine, materials science, analytical chemistry, etc. With the deepening of research, it will be able to bloom more splendid brilliance and contribute to the development of various fields.