1-(phenylsulfonyl)-1H-benzimidazole

1- (benzenesulfonyl) -1H-benzimidazole has a wide range of uses in various fields.
In the field of pharmaceutical chemistry, it is often a key intermediate for the creation of new drugs. Because the structure of benzimidazole has good biological activity and pharmacological properties, 1- (benzenesulfonyl) -1H-benzimidazole can be modified by specific chemical reactions to derive a variety of compounds with unique therapeutic effects. Or it can act on specific biological targets and has potential value in the treatment of certain diseases such as tumors and inflammation. Cover because its structure can interact with specific proteins and enzymes in vivo to regulate physiological processes, thus achieving the purpose of treatment. < Br >
In the field of materials science, it also has unique functions. Using this as a raw material, polymer materials with special properties can be prepared. Its structure imparts specific chemical and physical properties to the material, such as enhancing the stability and heat resistance of the material. The introduction of this structural unit in the synthesis of polymers can make the obtained materials maintain good properties under high temperatures and harsh chemical environments, and has great application potential in fields such as aerospace and electronic devices that require strict material properties.
In the field of organic synthetic chemistry, 1- (benzenesulfonyl) -1H-benzimidazole is an important synthetic building block. Organic chemists design and implement the synthesis of many complex organic molecules with its unique structure and reactivity. By selecting suitable reaction conditions and reagents, various functionalization reactions can be carried out on it, and a library of organic compounds with diverse structures can be constructed, providing rich compound resources for new drug research and development, new material creation, etc.

There are various ways to synthesize 1- (benzenesulfonyl) -1H -benzimidazole. First, the two interact in a suitable solvent and under mild reaction conditions. The amino activity of phthalamines is quite high, and it is easy to undergo nucleophilic substitution reaction with the acid chloride group of benzenesulfonyl chloride. In this process, it is necessary to pay attention to the control of the reaction temperature and time. If the temperature is too high, the side reactions will increase, and if the time is too short, the reaction will not be fully functional. Usually, organic solvents such as dichloromethane, N, N-dimethylformamide, etc. are used as the reaction medium and react at room temperature to 50 degrees Celsius for several hours to obtain intermediate products. Subsequently, the intermediate product is further converted into the target product 1- (benzenesulfonyl) -1H-benzimidazole after appropriate treatment, such as adjusting the pH value, recrystallization, etc.
In addition, benzimidazole can also be used as the starting material to react with the benzenesulfonylation reagent. For example, benzenesulfonyl chloride is selected to cooperate with a base, which can bind the acid and promote the reaction to proceed in a positive direction. During the reaction, benzimidazole is dissolved in a suitable solvent, such as acetonitrile, etc., a base (such as potassium carbonate, etc.) is added, and benzenesulfonyl chloride is slowly added dropwise. This reaction needs to be monitored and the reaction process can be monitored by means of thin-layer chromatography. After the reaction is completed, pure 1- (benzenesulfonyl) -1H -benzimidazole can be obtained by separation and purification methods such as column chromatography and distillation.
In addition, there is a strategy to gradually construct the benzimidazole structure and benzimidazole group by using benzene ring derivatives with specific substituents through multi-step reactions. Although this method is complicated, the structure of the product can be fine-tuned. First, the benzene ring derivative is properly modified, and an active group such as an amino group is introduced, and then it reacts with the sulfur-containing reagent to construct the benzenesulfonyl part, and then the cyclization reaction generates the benzimidazole structure. The whole process requires precise control of the reaction conditions at each step to improve the yield and purity of the product.

1 - (benzenesulfonyl) -1H -benzimidazole is one of the organic compounds. Its physical properties are quite well researched.
Looking at its appearance, under normal temperature and pressure, it is mostly in a solid state. Due to its strong intermolecular force, the molecules are closely arranged. The color is usually white to light yellow powder. The appearance of this color is due to the absorption and reflection characteristics of the molecular structure.
When it comes to melting point, due to the presence of benzene ring and heterocyclic structure in the molecule, forming a conjugated system and enhancing the intermolecular force, the melting point is relatively high, generally in a specific temperature range. This temperature range is determined by its precise molecular structure and interaction. < Br >
In terms of solubility, it has a certain solubility in common organic solvents, such as dichloromethane, chloroform, etc. Because the benzene ring and benzenesulfonyl group in its molecule have certain hydrophobicity, the non-polar part of the organic solvent can interact with it to promote dissolution. However, the solubility in water is very small, because the polarity of the water molecule interacts weakly with the hydrophobic part of the compound structure, it is difficult to break the original intermolecular force and disperse in water.
Its density is also one of the important physical properties. Due to the close arrangement of the molecular structure and the atoms, its density has a specific value, which reflects the mass distribution of the molecule in unit volume.
In addition, the stability of the compound is quite high. The chemical bond between the intramolecular benzimidazole ring and the benzenesulfonyl group is stable. Under normal conditions, it is not easy to break or rearrange the chemical bond. This stability is also closely related to its physical properties, which affects its performance during storage and use.

1 - (benzenesulfonyl) -1H - benzimidazole, this is an organic compound. Its chemical properties are unique and contain many wonders.
When it comes to acidity, the nitrogen atom on the benzimidazole ring can bind protons, so it is weakly acidic. In a specific basic environment, it can react with bases to form corresponding salts.
When it comes to nucleophilic substitution reactions, benzenesulfonyl groups, as electron-withdrawing groups, can reduce the density of electron clouds on the benzimidazole ring, making specific positions on the ring more vulnerable to nucleophilic reagents and triggering nucleophilic substitution reactions. For example, nucleophiles may attack the ortho or para-position of the carbon atom connected to the benzenesulfonyl group on the benzimidazole ring to achieve the substitution process.
In addition to redox properties, some atoms in the compound are in a specific oxidation state, and under the action of suitable oxidizing agents or reducing agents, redox reactions can occur. For example, in the case of strong oxidizing agents, some chemical bonds in the benzimidazole ring or benzenesulfonyl group may be oxidized, causing changes in its structure and properties.
In terms of stability, its structure is relatively stable, but under extreme conditions such as high temperature, strong acid, and strong base, the structure may be damaged. For example, in a strong acid environment for a long time, the benzenesulfonyl group may be detached from the benzimidazole ring, which changes the structure of the compound.
1- (benzenesulfonyl) -1H -benzimidazole has rich and diverse chemical properties and has important applications in many fields such as organic synthesis and medicinal chemistry. It can participate in the preparation and synthesis of a variety of compounds as a key intermediate.

There is a question today, what is the price of 1- (benzenesulfonyl) -1H -benzimidazole in the market. This is a compound in the field of fine chemicals, and its price often varies due to many factors.
Looking at the price of chemical products in the past, the abundance of raw materials has a great impact on their price. If benzene, sulfonyl chloride, etc. are abundant raw materials for the preparation of 1- (benzenesulfonyl) -1H -benzimidazole, the price will stabilize or drop; if the raw materials are scarce, the price will easily rise.
The simplicity of the process also affects its price. If the preparation method is complicated, multiple steps are required, and each step requires special conditions, expensive reagents or catalysts, the cost will be high, and its price in the market will also be high; if the process is simple, the price will be relatively easy.
Product purity is crucial. High purity of 1- (benzenesulfonyl) -1H -benzimidazole is commonly used in high-end fields such as medicine and electronics. Because of its strict requirements for impurities and difficulty in preparation, the price is high; low purity, or for general chemical synthesis, the price is low.
Market supply and demand is also key. If the market demand for it is strong and the supply is limited, if the amount of new pharmaceutical research and development increases greatly, the price will rise; if the supply exceeds the demand, the price will tend to fall.
However, it is difficult to determine the exact price of 1- (benzenesulfonyl) -1H -benzimidazole on the market today. For more information, you can consult the chemical raw material supplier, or check the recent transaction price on the chemical product trading platform to get a more accurate number.