1-(p-toluenesulphonyl)imidazole

The chemical structure of 1 - (p-toluenesulfonyl) imidazole is composed of an imidazole ring and a p-toluenesulfonyl group.
Looking at its imidazole ring, this is a five-membered heterocyclic ring containing two nitrogen atoms, which is aromatic. The nitrogen atoms on the ring each have their own unique properties. One nitrogen atom is connected to the carbon atom in the ring by a double bond, and the other is connected by a single bond. This structure endows the imidazole ring with a certain electron cloud distribution and chemical activity.
And the p-toluenesulfonyl group is composed of a p-toluenyl group and a sulfonyl group. The p-toluenyl group is a group that connects methyl groups on the benzene ring, which has certain hydrophobicity and electronic effects. In the sulfonyl group, the sulfur atom is connected to two oxygen atoms in a double bond, and the other oxygen atom forms a sulfur-oxygen bond, and the oxygen atom is connected to the imidazole ring.
Overall, the structure of 1- (p-toluenesulfonyl) imidazole makes this compound both reactive and p-toluenesulfonyl. The interaction of different groups in its structure determines its unique chemical behavior in the field of organic synthesis, and can participate in various reactions such as nucleophilic substitution. Because the nitrogen atom of the imidazole ring can be used as a nucleophilic check point, and the p-toluenesulfonyl group can be used as a leaving group or participate in the regulation of reaction activity and selectivity, occupying an important position in many reaction pathways of organic chemistry.

1- (p-toluenesulfonyl) imidazole, which is widely used. In the field of organic synthesis, it is often used as a strong nucleophilic reagent and can react with many electrophilic reagents, such as halogenated hydrocarbons and acid anhydrides. Through such reactions, various nitrogen-containing organic compounds can be prepared, such as imidazole derivatives, which are of great significance in the fields of medicinal chemistry and materials science. In drug research and development, many imidazole drugs are synthesized from 1- (p-toluenesulfonyl) imidazole, which has shown unique effects in antibacterial, antiviral, and antitumor.
In the field of materials science, materials prepared by 1- (p-toluenesulfonyl) imidazole participate in the reaction have special physical and chemical properties, such as specific electrical conductivity, optical properties, etc., and can be applied to the preparation of electronic devices and optical materials.
In addition, in the field of catalysis, 1- (p-toluenesulfonyl) imidazole can also play a role, which can be used as a ligand to complex with metal ions to form metal complexes with specific catalytic activities. It exhibits high catalytic performance in many organic reactions, promotes the reaction, and improves the reaction yield and selectivity. Overall, 1- (p-toluenesulfonyl) imidazole plays an indispensable role in many fields such as organic synthesis, drug development, materials science, and catalysis.

The synthesis of 1 - (p-toluenesulfonyl) imidazole is a key technique in the field of organic synthesis. Its synthesis often follows the following paths.
First, imidazole and p-toluenesulfonyl chloride are used as raw materials. In a suitable reaction vessel, add an appropriate amount of imidazole, and then dissolve it with a suitable organic solvent, such as dichloromethane, trichloromethane, etc., so that the imidazole is uniformly dispersed. Then, under low temperature and stirring conditions, slowly add the solution of p-toluenesulfonyl chloride dropwise. During this process, the reaction temperature should be strictly controlled, usually maintained at 0-5 ° C, to prevent side reactions from occurring. Add it dropwise and continue to stir to make the reaction fully proceed. The reaction process can be monitored by thin-layer chromatography (TLC). When the reaction is complete, wash the reaction solution with an appropriate amount of alkali solution, such as sodium bicarbonate solution, to remove the unreacted p-toluenesulfonyl chloride and the generated hydrogen chloride. Subsequently, the organic phase is separated, dried, and then distilled under reduced pressure to remove the organic solvent and obtain a crude product. Finally, purified by recrystallization, pure 1- (p-toluenesulfonyl) imidazole can be obtained.
Second, there is also a method of reacting imidazole salts with p-toluenesulfonyl reagents. First, the imidazole is converted to the corresponding imidazole salts, such as imidazole hydrochloride. Then, the imidazole salt is reacted with p-toluenesulfonyl lithium, p-toluenesulfonyl potassium and other reagents under suitable solvents and reaction conditions. The reaction conditions are relatively mild and the reaction selectivity is also high. After the reaction is completed, the target product can also be obtained through similar separation and purification steps, such as filtration, washing, recrystallization, etc.
These two synthesis methods have their own advantages and disadvantages. The former has easy raw materials and relatively simple operation; the latter has good selectivity and higher product purity. Synthesizers should carefully choose suitable methods according to actual needs and conditions to achieve the purpose of efficient and high-quality synthesis of 1- (p-toluenesulfonyl) imidazole.

1 - (p-toluenesulfonyl) imidazole, when storing and transporting, there are several ends that should be paid attention to. Its nature is active, and when exposed to water or moisture, it is easy to hydrolyze and lose its inherent properties. Therefore, it must be stored in a dry place, and when transporting, it should also be strictly prevented from water vapor invasion.
And because of its certain chemical activity, it can self-polymerize at high temperatures, or react with other substances, which will damage its quality. The storage and transportation temperature should be controlled at a lower range, generally no more than 25 ° C.
Furthermore, this substance may be irritating to a certain extent, and if it is accidentally contacted with the skin and eyes, it can cause discomfort. Therefore, when handling and disposal, use appropriate protective equipment, such as gloves, goggles, etc. And the packaging must also be sturdy and tight to prevent leakage. If there is any leakage, it should be disposed of in a proper manner to avoid harming the environment and people.
At the same time, 1- (p-toluenesulfonyl) imidazole may have a corrosive effect on certain materials. The containers used for storage and transportation equipment should be compatible with them, such as specific plastics, glass materials, etc., to ensure the stability of storage and transportation.

I don't know what the market price range of 1- (p-toluenesulfonyl) imidazole is. The price of these compounds often varies due to many factors, such as quality, source, supply and demand, and the amount purchased, and the quotations of different merchants in the market are also different.
If you want to get an accurate price, you can go to the chemical trading platform and chemical reagent supplier for details. Whenever there is a latest quotation there, you can get a suitable price according to the required quality and quantity. Or consult with chemical industry practitioners, purchasers, etc. They may be able to say the approximate range of market prices due to past experience. Unfortunately, it is difficult for me to determine the price range at this moment. I hope you can get a definite number according to the above method.