1 Methyl 1h Imidazole 4 Carboxylic Acid
quinoline thiophene imidazole thiazole

1-Methyl-1H-imidazole-4-carboxylic acid

    Specifications

    HS Code

    320718

    Chemical Formula C5H6N2O2
    Molar Mass 126.11 g/mol
    Appearance Solid
    Melting Point 170 - 174 °C
    Solubility In Water Soluble
    Pka Value Around 4.2
    Odor Odorless
    Density 1.33 g/cm³
    Cas Number 57559-62-3
    Boiling Point Decomposes

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    General Information
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    Frequently Asked Questions

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    What is the chemistry of 1-Methyl-1H-imidazole-4-carboxylic acid?
    1-Methyl-1H-imidazole-4-carboxylic acid, the chemical properties of this substance are quite unique. It is in solid form and has a certain stability. At room temperature, if there is no special chemical environment, its structure is relatively stable.
    From the perspective of its acidity and alkalinity, it shows acidic characteristics due to the carboxyl group. This carboxyl group can release protons under suitable conditions and neutralize with alkali substances, just like extinguishing a fire with water, combining acid and base to form corresponding salts and water.
    When it comes to solubility, it may have a certain solubility in some organic solvents. In case of alcohol solvents, some molecules may be evenly dispersed in them, just like sand entering water, gradually fusing. In water, its dissolution is also affected by factors such as temperature and pH.
    Then again, its reactivity is endowed with unique reactivity due to the existence of the imidazole ring. The nitrogen atom of the imidazole ring is like the "active point" of chemical reactions, and can react with many electrophilic or nucleophilic reagents. For example, it can react with acyl-halide reagents to form amide derivatives, just like a craftsman building a new substance with wood and stone, with both structure and properties changing.
    And because its structure has both a hydrophobic part of methyl and a hydrophilic part of carboxyl groups, this property makes it potentially useful in the fields of interface chemistry and other fields. Just like walking on water, depending on its hydrophilic and hydrophobic properties, it can exhibit unique behaviors at certain interfaces, or affect interfacial tension, or participate in interfacial adsorption processes.
    Its chemical properties are complex and interesting, and many properties are intertwined. It has potential application value in many fields such as organic synthesis and medicinal chemistry, and needs to be studied in depth by future generations like exploring treasures.
    What are the main uses of 1-Methyl-1H-imidazole-4-carboxylic acid?
    1-Methyl-1H-imidazole-4-carboxylic acid, an organic compound, has important uses in many fields.
    First, in the field of medicinal chemistry, this compound is a key intermediate. With exquisite chemical synthesis methods, it can be ingeniously converted into unique drug molecules. Because of its specific chemical structure and activity, it can precisely interact with specific targets in organisms, thus exhibiting unique pharmacological activities. For example, drugs developed in part based on this compound have shown remarkable potential in many important pharmaceutical fields such as anti-tumor, anti-inflammatory and antibacterial, providing new powerful weapons for human beings to fight diseases.
    Second, in the field of materials science, 1-methyl-1H-imidazole-4-carboxylic acid also plays an indispensable role. Integrating it into polymer materials can significantly improve the properties of materials. For example, it can enhance the stability of the material, making it more able to maintain its own characteristics under different environmental conditions; it can also improve the solubility of the material, making the material easier to disperse and process in specific solvents, thereby expanding the adaptability and practicality of the material in various application scenarios.
    Third, in the field of organic synthesis chemistry, it is a very commonly used starting material and reaction intermediate. With its special functional groups, it can participate in many classic organic reactions, such as acylation reactions, alkylation reactions, etc. Through these reactions, complex and diverse organic compounds can be constructed, greatly enriching the variety and structure of organic compounds, injecting a steady stream of vitality into the development of organic synthetic chemistry, and driving the field to new heights.
    What is the synthesis method of 1-Methyl-1H-imidazole-4-carboxylic acid?
    The synthesis method of 1-methyl-1H-imidazole-4-carboxylic acid has been known for a long time. In the past, many scholars have studied deeply in the field of organic synthesis, and this can also be used as a lesson.
    One of the methods is to use a suitable imidazole derivative as the starting material. First, a methyl group is introduced at a specific position on the imidazole ring through a clever reaction. This process requires careful selection of reagents and reaction conditions. The introduction of methyl is related to the structure and purity of the product. Halogenated methane reagents are commonly used. Under the catalysis of bases, nucleophilic substitution reactions occur with imidazole derivatives. In this way, the first position of the imidazole ring can be successfully connected to the methyl group. < Br >
    Then, the carboxyl group is to be introduced at the 4 position. This step can be achieved by means of specific carboxylation reagents, such as carbon dioxide or corresponding carboxylic acid derivatives. In an appropriate metal catalyst and reaction environment, the reaction occurs smoothly. If carbon dioxide is used as the carboxyl source, it is often necessary to react with the imidazole derivative containing methyl under a high pressure environment and a specific catalyst to generate the target 1-methyl-1H-imidazole-4-carboxylic acid.
    In addition, other compounds containing imidazole structures are also used as the starting point, and the structure of the target molecule is gradually constructed through a multi-step reaction. First, the functional groups of the starting material are modified and transformed, and through reaction steps such as substitution, addition, and oxidation, the synthesis of 1-methyl-1H-imidazole-4-carboxylic acid is gradually achieved. Each step of the reaction needs to be precisely controlled, and attention should be paid to the selectivity and yield of the reaction in order to achieve the purpose of synthesis.
    The way of synthesis varies widely, but it is necessary to follow the principles of organic chemistry, observe the reaction conditions carefully, and operate cautiously to obtain a good method for this compound.
    What is the price range of 1-Methyl-1H-imidazole-4-carboxylic acid in the market?
    The price of 1-methyl-1H-imidazole-4-carboxylic acid in the market varies for various reasons. Its price often depends on the state of production and demand, the difference in quality, the amount purchased, and the state of supply.
    Looking at past market conditions, if the purchase quantity is very small, it is only for experiments or small tests, and the price may be higher in chemical malls or reagent sales. The price per gram may reach tens of gold, or even higher, depending on the merchant and the quality.
    However, if it is purchased for industrial mass production, the dosage is quite huge, such as hundreds of kilograms or even several tons at a time, the price should be reduced. Under such circumstances, suppliers are often willing to reduce their prices due to large profits. The price per kilogram may fall to hundreds of gold.
    In addition, quality products are also the main reason for the price. High purity, refined products, the price is not cheap; while universal products, the price may be slightly lower. And the production demand is also loud. If the situation needs to be prosperous and the production is small, the price will rise; on the contrary, the production needs to be weak, the price may fall.
    As for the exact number, it is difficult to give. To know the exact price, when consulting chemical suppliers, reagent merchants, or referring to the price information of chemical trading platforms, you can get the current actual price.
    What are the storage conditions for 1-Methyl-1H-imidazole-4-carboxylic acid?
    1-Methyl-1H-imidazole-4-carboxylic acid, this is a chemical substance. Its storage conditions are quite important, which is related to its quality and stability.
    According to the general principles of chemistry, it should be placed in a cool and dry place. If the temperature is too high, it is easy to cause chemical reactions, or cause decomposition and deterioration. If the temperature exceeds the appropriate range, the molecular movement will intensify, or the chemical bonds will be broken, which will damage its chemical structure.
    A dry environment is also indispensable. Water vapor in the air may interact with the substance to initiate reactions such as hydrolysis. If the environment is humid, the water vapor will adsorb on the surface of the substance, or penetrate into the interior, changing its chemical properties.
    Furthermore, it needs to be stored in a well-ventilated place. This is to prevent the accumulation of volatile gas, one is to avoid the potential safety hazard caused by high gas concentration, and the other is to avoid the reaction with air components at local high concentrations.
    In addition, it should be kept away from fire sources, heat sources and strong oxidants. This substance may be flammable, and it is easy to catch fire or even explode in case of fire and heat sources. Strong oxidants are highly oxidizing, and contact with them may cause severe oxidation reactions and cause the substance to deteriorate.
    When storing, it is appropriate to use a sealed container. Sealing can prevent air and water vapor from invading and keep its chemical properties stable.
    In summary, 1-methyl-1H-imidazole-4-carboxylic acid should be stored in a cool, dry and ventilated place in a sealed container, away from fire, heat and strong oxidants, so as to ensure its quality and safety.