1-methyl-1,3-dihydro-2H-imidazole-2-thione

1 - methyl - 1,3 - dihydro - 2H - imidazole - 2 - thione, the Chinese name is often 1 - methyl - 2 - mercapto imidazoline. The chemical structure of this compound has an imidazoline ring, which consists of two nitrogen atoms and three carbon atoms to form a five-member heterocyclic ring. There is a double bond in the ring, which makes the ring aromatic. The methyl is connected at 1 position, the sulfur atom is replaced by the oxygen atom at 2 positions to form a thione group, and the hydrogen atom is connected at 3 positions. This structure endows it with specific chemical properties and reactivity, and may have various applications in organic synthesis, medical chemistry. Its structure is unique. In the reaction, thione groups may exhibit nucleophilicity, participate in nucleophilic substitution reactions, and interact with suitable electrophilic reagents to form new carbon-sulfur bonds or other bonds to expand molecular structures. Nitrogen atoms on the ring have lone pair electrons, or can participate in coordination chemistry, forming complexes with metal ions, which affect the chemical properties and reactivity of metal ions. The presence of methyl groups also affects the molecular spatial structure and electron cloud distribution, or changes the physical properties of compounds such as solubility and boiling point. In different chemical reaction scenarios, this structural feature is a key consideration.

1 - methyl - 1,3 - dihydro - 2H - imidazole - 2 - thione is an organic compound with specific physical properties. Its shape is either solid and stable at room temperature. In case of high temperature, open flame or strong oxidizing agent, or reaction, it needs to be properly stored.
Look at its melting point, which is about 180 - 185 ° C. The melting point is the temperature at which a substance changes from solid to liquid. If the melting point of this compound is in this range, it means that it needs to reach the corresponding temperature to change its shape.
As for the boiling point, it can be boiled due to the structure and intermolecular forces, or at a higher temperature. Although exact data are not available, it is speculated that the boiling point may be higher according to its chemical properties and similar structural compounds. Due to the cyclic structure and sulfur atoms in the molecule, the intermolecular force is enhanced, and more energy is required to make it boil.
In terms of solubility, this compound has a certain solubility in organic solvents such as ethanol and acetone. For ethanol and acetone, common organic solvents also have specific polarities. The compound can dissolve in it, or because of the interaction between its structure and solvent molecules, such as van der Waals force, hydrogen bond, etc. However, the solubility in water may be limited, due to the poor matching of water polarity and compound structure and polarity.
Its density is also an important physical property. Although the exact value is unknown, it can be estimated according to the structure and composition. The molecule contains carbon, hydrogen, nitrogen, and sulfur atoms. Due to the atomic weight and spatial arrangement, the density may be similar to that of common organic compounds, ranging from 1.1 to 1.3 g/cm ³. This density range indicates that it is slightly heavier than water.
In addition, the compound may have a certain smell, but the relevant description is rare. According to the general nature of sulfur-containing organic compounds, or have a special smell, or pungent, or unpleasant smell, the presence of sulfur atoms is affected.

1-Methyl-1,3-dihydro-2H-imidazole-2-thione, commonly known as 1-methylimidazoline-2-thione in Chinese. This substance has a wide range of uses and has its influence in many fields.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. Through specific chemical reactions, it can be ingeniously converted into sulfur-containing heterocyclic compounds with different structures, which often have unique biological activities. Some drugs derived from this have shown significant effects in antibacterial, antiviral and antitumor. For example, through a series of complex reaction steps, researchers have successfully built it into the core structure of a new type of antimicrobial drug, which has a strong inhibitory effect on specific types of bacteria, opening up a new path for pharmaceutical research and development.
In the field of materials science, 1-methylimidazoline-2-thione also plays a pivotal role. It can be integrated into polymer materials as an excellent additive, which can effectively improve some properties of materials. Taking a certain type of plastic material as an example, after adding an appropriate amount of this substance, the oxidation resistance and thermal stability of the material are greatly enhanced, making the plastic less prone to aging and deformation in high temperature environments or long-term use, greatly expanding its application scenarios and service life.
In the field of chemical production, it is often involved in the synthesis process of various fine chemicals. For example, the preparation of some special dyes, fragrances, etc., 1-methylimidazoline-2-thione can impart special color, smell and other properties to the product with its unique chemical structure. For example, in the synthesis of specific dyes, it is used as a key reaction raw material. After a multi-step reaction, the resulting dye is not only brightly colored, but also has excellent light resistance and washable fastness, making it widely used in the textile printing and dyeing industry.

1 - methyl - 1,3 - dihydro - 2H - imidazole - 2 - thione, the Chinese name is often 1 - methyl - 2 - mercaptoimidazoline. There are many ways to synthesize this compound, which are described in detail below.
First, ethylene diamine and formic acid are used as starting materials. First, ethylene diamine and formic acid are reacted under specific conditions to form imidazoline derivatives. This reaction requires suitable temperature and pressure, and also requires the proportion of reactants. Too high or too low temperature will affect the formation and purity of the product. When ethylene diamine reacts with formic acid, the intermediate is formed, and then the intermediate is further cyclized to form imidazoline structure. At this time, if methyl is introduced, a specific methylation reagent, such as iodomethane, is required to carry out methylation reaction in an alkaline environment to obtain the target product 1-methyl-2-mercaptoimidazoline.
Second, 1,2-dibromoethane and thiourea are used as the starting materials. The reaction of 1,2-dibromoethane and thiourea will generate intermediates containing thiourea groups. This reaction is carried out in a suitable solvent, such as ethanol, etc. Heating can accelerate the reaction process. The resulting intermediate is then reacted with a methylation reagent to introduce methyl. After that, through cyclization, an imidazoline ring is constructed, and the final product is obtained. In the reaction process, it is necessary to pay attention to the reaction conditions of each step, such as temperature, pH, etc., which are all related to the yield and purity of the product.
Third, formaldehyde, ethylenediamine and carbon disulfide are used as raw materials. Formaldehyde and ethylenediamine first condensate to form an imine intermediate, which then reacts with carbon disulfide to form a sulfur-containing structural intermediate. Subsequently, methyl is introduced through methylation reaction, and then cyclized to form 1-methyl-2-mercaptoimidazoline. The raw materials for this route are common and easy to obtain, but the control of reaction conditions in each step is relatively high. For example, the condensation reaction of formaldehyde and ethylenediamine is extremely critical to the control of pH and temperature. Otherwise, by-products are easily formed, which affects the yield and quality of the target product
The above synthesis methods have their own advantages and disadvantages. According to the actual situation, such as raw material availability, cost, and product purity requirements, the appropriate method should be weighed to achieve the best synthesis effect.

1 - methyl - 1,3 - dihydro - 2H - imidazole - 2 - thione is a chemical substance, commonly known as methimazole. When storing and using, be sure to pay attention to the following matters.
One is storage. This substance should be stored in a cool, dry and well-ventilated place. Due to its nature or affected by temperature and humidity, if the environment is hot and humid, it may deteriorate, so it should be avoided from direct sunlight and heat sources. And it needs to be stored separately from oxidizing agents, acids and other substances. Due to its chemical activity, it can mix with other substances or react violently, causing danger. The storage place should also be clearly marked for identification, and the storage condition should be checked regularly to see if there are any signs of deterioration.
The second is about use. Users must have professional knowledge and skills, familiar with its chemical properties and latent risks. Before use, read the relevant information and safety operating procedures carefully. When operating, appropriate protective equipment should be worn, such as protective gloves, goggles and protective clothing, to prevent contact with skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the situation. Use in the fume hood to avoid the accumulation of volatile gases in the environment and the risk of inhalation. During use, precisely control the dosage and operate according to the experimental or production requirements to prevent random increase or decrease. After use, properly dispose of the remaining substances and waste, and must not be discarded at will. They must be disposed of in accordance with relevant environmental regulations to prevent environmental pollution.