1-(ethylsulfonyl)-2-methyl-1H-benzoimidazole

1 - (ethanesulfonyl) - 2 - methyl - 1H - benzimidazole is an organic compound with unique chemical properties.
This compound is planar and rigid due to its core structure of benzimidazole, which has a great impact on its physical and chemical behavior. The benzimidazole ring endows it with certain aromaticity, enhances its stability, and has a unique electron cloud distribution, which can participate in various electron transfer and chemical reactions.
Its 1 position is connected to ethanesulfonyl group, which has strong electron absorption and can change the electron cloud density of the benzimidazole ring and shift the electron cloud on the ring to ethanesulfonyl group. In this way, the electrophilicity of the compound changes, making it easier to react with the nucleophilic reagent. For example, under suitable conditions, the sulfur atom of ethanesulfonyl can be attacked by the nucleophilic reagent and a substitution reaction occurs. The methyl group at the
2 position is relatively small, which has an electron-induced effect and has a certain effect on the electron cloud density of the benzimidazole ring. Although the degree is not as significant as that of the ethanesulfonyl group, it will affect the spatial structure and electron distribution of the compound, and change the intermolecular force. The presence of methyl groups increases the steric resistance of the compound slightly. In some reactions, it will hinder or guide the reactants to approach the specific position of the benzimidazole ring.
In terms of acidity and alkalinity, the nitrogen atom of the 1H-benzimidazole ring has a certain alkalinity and can accept protons, but the electron-absorbing action of ethylsulfonyl will weaken its basicity. Therefore, the compound is weak in alkalinity, and under acidic conditions, it may protonate, generate corresponding salts, and change its solubility and reactivity.
In terms of solubility, because it contains polar ethylsulfonyl group and relatively non-polar benzimidazole ring and methyl group, it has a certain solubility in polar organic solvents such as ethanol and acetone, but its solubility in water is not good, because the overall hydrophobicity is still strong. < Br >
This compound has a wide range of uses in the field of organic synthesis and can be used as an intermediate. With the help of the reactivity of ethanesulfonyl groups and methyl groups, through substitution, addition and other reactions, organic compounds with more complex structures and unique functions can be constructed. It is of great significance in many fields such as medicinal chemistry and materials science.

1 - (ethanesulfonyl) - 2 - methyl - 1H - benzimidazole, which is one of the organic compounds. It has a wide range of uses and is of great value.
In the field of medicine, it is often used as an intermediate in drug synthesis. Due to its special chemical structure, it can participate in the construction of many drug molecules and make great contributions to drug research and development. For example, it can be integrated into the molecular structure of antibacterial drugs through specific chemical reactions to give drugs more excellent antibacterial activity, thereby effectively inhibiting the growth of bacteria and helping to treat diseases.
In the field of materials science, 1 - (ethanesulfonyl) - 2 - methyl - 1H - benzimidazole also shows unique uses. It can be added to polymer materials as a functional additive. In this way, the properties of polymer materials can be improved, such as enhancing the stability of the material, so that it can maintain good performance under different environmental conditions; or improving the conductivity of the material, providing the possibility of manufacturing special conductive materials.
In addition, this compound also plays a key role in the preparation of some fine chemical products. Or it can be used to prepare special dyes, pigments and other products. By virtue of its structural characteristics, it gives the product more excellent color stability and dyeing performance, thereby enhancing product quality and market competitiveness.
In short, 1- (ethylsulfonyl) -2 -methyl-1H -benzimidazole plays an indispensable role in many fields such as medicine, materials science and fine chemicals, and has made a lot of contributions to the development of related industries.

The method for synthesizing 1 - (ethylsulfonyl) -2 - methyl - 1H - benzimidazole is as follows:
First take an appropriate amount of o-phenylenediamine and place it in a clean reaction vessel. Add an appropriate amount of 2 - methyl - 1 - (ethylsulfonyl) - 1H - benzimidazole - 5 - carboxylic acid or its corresponding active derivatives, such as acid chloride, acid anhydride and the like. The molar ratio of o-phenylenediamine to the carboxylic acid or its derivatives needs to be precisely prepared to achieve the best reaction effect, generally about 1:1.2 to 1:1.5.
Next, an appropriate amount of organic solvent, such as dichloromethane, N, N-dimethylformamide, etc., is added to fully dissolve the reactants and form a uniform reaction system, which is conducive to the reaction.
In the reaction system, an appropriate amount of catalyst, such as concentrated sulfuric acid, p-toluenesulfonic acid, etc., needs to be added to accelerate the reaction process. The amount of catalyst is about 1% - 5% of the total mass of the reactants.
Then, the reaction vessel is sealed and placed at a suitable temperature for the reaction. The reaction temperature depends on the characteristics of the reactants and catalysts, and is generally controlled at 80 ° C - 120 ° C. During the reaction, it is necessary to continuously stir with a magnetic stirrer to make the reactants fully contact and react evenly.
After several hours of reaction, wait for the reaction system to cool to room temperature. Pour the reaction solution into an appropriate amount of ice water, and precipitate out. Filtrate with Brinell funnel, collect the precipitate, and wash it repeatedly with deionized water to remove impurities.
The crude product obtained can be further purified by recrystallization method. Select a suitable recrystallization solvent, such as ethanol, ethyl acetate, etc., heat to dissolve the crude product, and filter it while hot. After the filtrate cools, a pure 1- (ethylsulfonyl) -2 -methyl-1H -benzimidazole crystal precipitates. The crystals are collected and dried in an oven at low temperature to obtain the target product. During the entire synthesis process, attention should be paid to the control of reaction conditions, the amount of solvent and catalyst, and the operation specifications of each step to obtain a product with higher yield and purity.

I do not know for sure that 1- (ethylsulfonyl) -2-methyl-1H-benzoimidazole in the market price range. The price of this compound often varies due to various factors. The difficulty of preparation, if the preparation process is complicated and the raw materials are rare, the cost will be high, and the price will rise accordingly; and the preparation is simple, the raw materials are widely distributed, and the price may be relatively easy.
Furthermore, the market supply and demand situation also affects the price. If the demand is strong and the supply is short, the price tends to rise; if the demand is low and the supply is sufficient, the price may be downward. In addition, the purity of the product is also the key. High purity, because the purification cost is high, the price must be higher than that of low purity.
There are different suppliers, and different merchants have different pricing due to different cost control and business strategies. And the amount of purchase will also affect the price, and bulk purchases may be discounted.
With the current trend, there is no exact information on its price range. For details, you can consult chemical product suppliers, chemical raw material trading platforms, or inquire at relevant industry exhibitions to get a more accurate price range.

1 - (ethanesulfonyl) - 2 - methyl - 1H - benzimidazole, the safety and risk of this substance are related to many aspects, let me tell you one by one.
In terms of chemical properties, this compound has a specific chemical structure and active group. The presence of ethanesulfonyl and methyl groups affects its physical and chemical properties. Under specific conditions, it may participate in chemical reactions. If it is not handled properly, it can be mixed with other substances, or cause undetectable reactions. This is one of the latent risks.
In terms of toxicity, there is no detailed and conclusive study to clarify its exact toxicity to organisms. However, analogous to similar compounds containing benzimidazole structures, some of them have certain toxicity, or affect the physiological functions of organisms, such as interfering with cell metabolism, damaging organs, etc. If accidentally exposed, absorbed through the skin, inhaled or eaten by mistake, it may endanger health.
Environmental impact cannot be ignored. If this substance enters the environment, its degradation characteristics are unknown. Or persists in the environment, accumulates in soil, water bodies, etc., affecting the balance of ecosystems and causing potential harm to animals and plants.
During production and use, risks also exist. During production, chemical synthesis steps are involved, and raw materials and intermediates may be dangerous. Strict procedures must be followed to prevent accidents. When using, if used in specific industrial processes or products, it is necessary to consider its impact on product quality and safety, and to prevent leakage from causing harm to the surrounding environment and people.
In conclusion, the safety and risk of 1- (ethanesulfonyl) -2-methyl-1H-benzimidazole are difficult to fully and accurately evaluate due to limited research. In activities involving this substance, it is necessary to exercise caution and strengthen research and supervision to ensure safety.