1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole

1 - [ (4 -methylphenyl) sulfonyl] -1H -benzimidazole is used in various fields such as medicine and chemical industry.
In the field of medicine, it is often the key intermediate for the creation of new drugs. Due to its unique chemical structure, it endows drugs with specific biological activities and pharmacological effects. For example, some drugs made from this base have great potential for the treatment of specific diseases, or can act on specific targets in the body. By regulating physiological and biochemical processes, they can achieve therapeutic purposes, such as targeting certain tumor diseases, inflammatory reactions or neurological diseases. Drugs with significant efficacy and less side effects are expected to be developed. < Br >
In the chemical industry, it also plays an important role. First, it can be used as a modifier for polymer materials, added to polymers, which can improve the properties of materials, such as improving the thermal stability, mechanical properties or chemical resistance of materials, so that materials can better meet various industrial needs. Second, in organic synthesis chemistry, in order to build the key building blocks of complex organic molecular structures, various organic reactions can be used to derive compounds with rich structures, expand the scope of organic synthesis, and promote the research and development and production of fine chemical products.
In conclusion, 1- [ (4-methylphenyl) sulfonyl] -1H-benzimidazole is of great significance in the development of the pharmaceutical and chemical industries, providing an important material foundation and development opportunity for research and application in many related fields.

1 - [ (4 - methylphenyl) sulfonyl] - 1H - benzimidazole, is a kind of organic compound. Its physical properties are of great value to explore.
First of all, its appearance is often solid, and the color is either white or nearly white. It is delicate and uniform. It looks like frost and snow, and the tentacles feel dry.
When it comes to the melting point, it is about a specific temperature range. This temperature is the critical point for the substance to change from solid to liquid. When the ambient temperature gradually rises to the melting point, the compound begins to melt, just like when ice meets warm spring, it slowly turns invisible. The exact value of its melting point depends on accurate experimental determination, but it is roughly within a certain range, which is of important significance for the identification and purification of substances.
Furthermore, its solubility is also one of the key physical properties. In organic solvents, such as common ethanol and dichloromethane, the compound exhibits certain solubility characteristics. In ethanol, the degree of dissolution varies with the rise and fall of temperature and the change of solvent ratio. Moderate heating, or increasing the amount of dissolution in ethanol, is like melting snow in warm water in winter, gradually melting and gradually disappearing. In water, its solubility is relatively limited, and it is difficult to form a homogeneous solution. It is mostly suspended, like gravel entering water, and difficult to melt. < Br >
Its density is also a factor that characterizes physical properties. Although the exact density needs to be measured by rigorous experiments, it is conceivable that it is similar to the density of common organic solids and has a certain sense of weight. When placed in the hand, it can feel its stable texture. This density is necessary to consider in scenarios such as chemical applications and material transportation.
It also has its stability. Under the environment of room temperature and pressure without special chemical action, 1- [ (4-methylphenyl) sulfonyl] -1H-benzimidazole is relatively stable, and the structure is not easy to be damaged. It is like the water of a quiet deep pool, which is not turbulent. However, in case of extreme conditions such as high temperature and strong acid and alkali, its structure may change, and its chemical properties will also change accordingly, like burning wood with fire, which is beyond recognition.

To obtain a chemical synthesis method of 1- [ (4-methylphenyl) sulfonyl] -1H-benzimidazole, the method is as follows:
First take o-phenylenediamine and p-toluenesulfonyl chloride as raw materials. In a suitable reaction vessel, an organic solvent such as dichloromethane, N, N-dimethylformamide, etc. is used as a medium to mix the two. The reaction system needs to be opened in a low temperature environment, such as in an ice bath, to facilitate a smooth initiation of the reaction. Due to the high activity of p-toluenesulfonyl chloride, low temperature can prevent its overreaction.
Subsequently, slowly add acid binding agents such as triethylamine. The function of acid binding agent is to neutralize the hydrogen chloride generated by the reaction, so that the reaction balance moves in the direction of the product. The speed of dropwise addition needs to be carefully controlled. If it is too fast, it is easy to cause local overheating of the system and affect the purity of the product. If it is too slow, it will take too long and reduce the reaction efficiency.
After the dropwise addition is completed, gradually raise the temperature to room temperature and continue to stir to make the reaction fully proceed. During this period, the reaction process can be monitored by thin-layer chromatography (TLC) to understand the consumption of raw materials and the formation of products.
When the reaction reaches the expected level, stop stirring. Pour the reaction solution into an appropriate amount of water and extract the product with an organic solvent. After extraction, the organic phases are combined and washed with dilute acid, dilute alkali and water successively to remove unreacted raw materials, acid binding agents and other impurities.
After washing, the organic phase is dried with a desiccant such as anhydrous sodium sulfate. After filtering off the desiccant, the organic solvent is removed by distillation under reduced pressure to obtain a crude product.
The crude product needs to be further purified. The method of recrystallization can be adopted. A suitable solvent such as ethanol, ethyl acetate, etc. is used to dissolve the crude product under heating conditions, and then slowly cooled to allow the product to crystallize and precipitate. After suction filtration and drying, a pure 1- [ (4-methylphenyl) sulfonyl] -1H -benzimidazole is finally obtained.

The price range of 1 - [ (4-methylphenyl) sulfonyl] -1H-benzimidazole in the market is difficult to determine. The price of this product often varies due to many factors, such as the quality of the product, the status of supply and demand, the cost of production, and the scale of the transaction.
If the quality is high, the raw materials are excellent and the process is fine, and it meets high standards of purity and quality specifications, the price may be higher; on the contrary, if the quality is slightly inferior, the price may be slightly lower.
On the supply and demand side, if there are many people who want it, and the supply is small, the price will rise; if the market supply is abundant and the demand is flat, the price may decline.
The cost of production is also the key. The price fluctuations of raw materials, the complexity of the synthesis process, and the amount of energy consumption all affect the final selling price. Complex synthesis processes require high-end equipment and technology, and the cost is high, and the price follows.
Transaction scale also has an impact. Bulk purchases, due to large quantities, sellers may give discounts, and the unit price is lower; sporadic purchases, the unit price may be higher.
Today in the market, the price of this product may fluctuate between a few yuan to tens of yuan per gram, but this is only a rough estimate. The actual price should be consulted in detail with the supplier or on the chemical product trading platform to obtain a more accurate figure.

1-% 5B% 284 - methylphenyl%29sulfonyl%5D - 1H - benzimidazole, this is a kind of organic compound. As for its manufacturer, I have searched the classics and know that there are many manufacturers involved in the production of this product.
One, Sigma - Aldrich Company, has a long-standing reputation and is respected in the field of chemical reagents. Its products are diverse and of high quality, and are trusted by many scientific research institutions and enterprises. When producing this product, strict standards and procedures must be followed to ensure the best quality.
Second, Alfa Aesar Company, is also a leader in the industry. Its production process is exquisite, focusing on R & D and innovation. It produces 1-% 5B% 284 - methylphenyl%29sulfonyl%5D - 1H - benzimidazole, which is often supplied in the fields of scientific research experiments and industrial production.
Furthermore, some domestic manufacturers are also involved in the production of this product. For example, some fine chemical enterprises, with their own technical strength and production experience, are committed to producing such compounds. They continuously optimize the production process and improve product quality to meet the diverse needs of the market.
Foreign manufacturers, with their advanced technology and profound heritage, occupy an important position in the global market. Domestic manufacturers, on the other hand, have a place in the domestic market by virtue of cost advantages and the convenience of local services. With the continuous advancement of technology, domestic and foreign manufacturers are continuously improving product quality and production efficiency to cope with the intense market competition.