1-(4-Fluorobenzyl)-2-Chloro-Benzimidazole

(1) Regarding "1 - (4 - hydroxyl) ", this expression is not complete. In chemistry, it is difficult to know the specific meaning and reaction direction of such a representation alone. "Hydroxyl" is a common functional group in organic chemistry, written -OH. To carry out relevant operations or explore its chemical significance, a more complete description of the chemical environment and specific reactions is required.
(2) Chemical structure of sulfonic acid thiazole: Sulfonic acid thiazole compounds are a class of heterocyclic compounds with a specific structure. Thiazole itself is a five-membered heterocyclic ring containing a sulfur atom and a nitrogen atom, and its ring structure has certain stability and special electronic effects. When the thiazole ring is combined with a sulfonic acid group, the sulfonic acid group-SOH is usually attached to a certain carbon atom of the thiazole ring.
From the perspective of structural characteristics, the thiazole ring imparts certain aromatic and biological activity to the whole molecule, while the introduction of the sulfonic acid group significantly increases the water solubility of the compound. This is because the sulfonic acid group is a strong hydrophilic group that can form hydrogen bonds with water molecules. In some pharmaceutical molecules or functional materials, the sulfonic acid thiazole structure has attracted much attention due to its hydrophilicity and specific biological activity check points.
In the spatial structure, the thiazole ring presents a planar or nearly planar configuration, and the spatial orientation of the sulfonic acid group affects the shape and interaction of the whole molecule. The atoms in its chemical structure are interconnected by covalent bonds, and the electron cloud distribution and bonding mode of each atom determine the chemical and physical properties of the compound, such as its acidity and alkalinity, reactivity, etc.

1. About " (4 -hydroxyl) ": In the field of chemistry, the hydroxyl group is a common functional group with the chemical formula -OH. It is widely present in many organic compounds and has an important impact on the properties of the compounds. For example, in alcohols, the hydroxyl group makes the alcohol have a certain hydrophilicity and can form hydrogen bonds with water molecules, thereby affecting its solubility; in phenolic compounds, the hydroxyl group is connected to the benzene ring, which will change the electron cloud density of the benzene ring and affect the chemical activity of phenolic substances, such as more prone to substitution reactions.
2. About "The main uses of bromobenzothiazole": Bromobenzothiazole compounds have important uses in many fields. < Br > - ** Pharmaceutical field **: Some bromobenzothiazole derivatives have potential biological activities and can be used as lead compounds for drug research and development. For example, some compounds with bromobenzothiazole structure are studied for the development of anti-tumor drugs, which can inhibit tumor growth by specific mechanisms of action, such as inhibiting the proliferation signaling pathway of tumor cells; some can be used for the development of antibacterial drugs, which have inhibitory or killing effects on some bacteria, and play an effect by interfering with the metabolic process of bacteria or destroying their cell membranes.
- ** Materials Science field **: Can be used to synthesize materials with special properties. For example, the introduction of bromobenzothiazole into the structure of polymer materials can improve the optical properties of materials and make them have better fluorescence characteristics, which can be applied to the manufacture of optoelectronic devices such as fluorescent probes and Light Emitting Diodes; at the same time, it can also enhance the stability and corrosion resistance of materials, which has application value in materials used in some special environments.
- ** Analytical Chemistry Field **: Bromobenzothiazole compounds can be used as analytical reagents. For example, using them to react specifically with certain metal ions to generate complexes with specific color or fluorescence changes, so as to realize the qualitative or quantitative analysis of metal ions, and play a role in environmental monitoring, ore analysis, etc.

To prepare 1- (4-hydroxybenzyl) -2-bromobenzonitrile and obtain its synthesis method, the following method can be used.
First take a suitable starting material, if the common aromatic hydrocarbon compound is used as the starting point, through a specific substitution reaction, the desired functional group is introduced. If a benzene ring derivative is selected, a hydroxyl-protected benzyl group is introduced into its para-position, which can be achieved by nucleophilic substitution reaction. When a halogenated benzyl compound is reacted with a nucleophilic reagent containing hydroxyl groups in a suitable base and solvent environment, such as potassium carbonate as a base, N, N-dimethylformamide (DMF) as a solvent, heated and stirred, the product with protective hydroxyl benzyl in the para-position can be obtained.
Then, the ortho-position of the benzene ring is brominated. In this step, a brominating reagent, such as liquid bromine, can be used to react in the presence of a suitable catalyst. Commonly used catalysts include iron powder or iron tribromide. Under low temperature and inert gas protection, liquid bromine is slowly added to the reaction system containing the above products to control the reaction temperature and time, so that bromine atoms precisely replace hydrogen atoms in the ortho-position of the benzene ring.
After the bromination reaction is completed, the protecting group of the hydroxy group needs to be removed to obtain a compound of 1- (4-hydroxybenzyl) -2-bromobenzyl. According to the type of protecting group used, select the appropriate deprotection method. If it is a methoxymethyl (MOM) protecting group, the reaction can be stirred at room temperature under acidic conditions, such as dilute hydrochloric acid as a reagent, to achieve the purpose of deprotection.
Finally, the obtained 1- (4-hydroxybenzyl) -2-bromobenzyl compound is converted into a nitrile group. This can be achieved by reacting with cyanide reagents, such as potassium cyanide or sodium cyanide, in the presence of a phase transfer catalyst, in a suitable solvent. Using tetrabutylammonium bromide as a phase transfer catalyst and dichloromethane as a solvent, heating and refluxing promote the substitution of halogen atoms with cyanyl groups to obtain 1- (4-hydroxybenzyl) -2-bromobenzonitrile.
The entire synthesis process requires fine control of the conditions of each step of the reaction, including temperature, time, and reagent dosage, etc., and proper separation and purification are required after each step of the reaction, such as column chromatography, recrystallization, etc., to ensure the purity and yield of the final product.

What I am asking you is about the physical properties of (4-hydroxy) and hydroxylamine hydrazine. These two have unique properties and each has its own use in the field of chemistry.
First, (4-hydroxy), which is a common group in organic compounds. The hydroxyl group has polarity. Due to the strong electronegativity of the oxygen atom, the hydrogen-oxygen bond has a dipole moment. This polarity makes the compound containing (4-hydroxy) easy to form hydrogen bonds with water, so it has a certain degree of water solubility. And the presence of hydroxyl groups makes the boiling point of the compound higher than that of hydrocarbons with the same number of carbons, and the force of covering hydrogen bonds increases the force between molecules. And because of its active hydrogen, it can participate in many chemical reactions, such as esterification, substitution, etc.
As for hydroxylamine hydrazine, it is a nitrogen-containing compound. Nitrogen atoms have lone pairs of electrons, making the substance alkaline to a certain extent. Its physical form, at room temperature or as a solid, depends on its structure and purity. Because it contains multiple nitrogen atoms, the intermolecular force is complex and has certain stability. And because of its high nitrogen content, it may have application potential in some fields, such as propellants. Its solubility is also affected by the molecular structure. If the molecule contains more polar groups, or has a certain solubility in polar solvents. < Br >
The physical properties of these two are characterized by the characteristics of functional groups in the structure, in terms of solubility, melting boiling point and intermolecular forces, etc., and are of great significance in chemical research and industrial applications.

"Tiangong Kaiwu" is written by Song Yingxing in the Ming Dynasty, and it is also an ancient book related to the craftsmanship and creation of all things. However, it is not detailed in the price range of (4-furanyl) -2-furanothiazole above the market.
Guy "Tiangong Kaiwu" was formed in the Ming Dynasty. At that time, chemically synthesized (4-furanyl) -2-furanothiazole and other substances were not yet known to the world. It is recorded in the book, and it was mostly the common agricultural mulberry, hardware, pottery, smelting and other processes at that time. The materials were all derived from daily production and life. With the scientific and technological level at that time, it was impossible to prepare and trade this compound.
(4-furanyl) -2-furanothiazole is a product in the field of modern chemistry. Its preparation relies on advanced chemical synthesis methods and professional instruments and equipment. As for its market price, it changes constantly, often due to purity, output, market supply and demand and many other factors. For details, it is appropriate to inquire about it on the trading platform of modern chemical products and chemical raw material suppliers, or to clarify its price range, which is beyond what Tiangong Kaiwu can describe.