1-[4-(4-Chlorophenyl)-2-hydroxyl-butyl]-1H-imidazole

1 - [4 - (4 - cyanobenzyl) - 2 - naphthyl - 1 - yl] - 1H - pyrazole The main use of this compound is in the scope of "Tiangong Kaiwu", or it can be slightly speculated from the perspective of ancient process chemistry.
Although there is no exact understanding of this specific compound in ancient times, it may be related to the synthesis and application of similar substances. In ancient alchemy and early drug preparation, the treatment and transformation of various organic and inorganic substances were often involved.
From a structural point of view, this compound contains structural units such as pyrazole rings. Pyrazole compounds often have certain biological activities and are often used in the field of medicine and pesticides in modern times. Although there was no modern concept of medicine and pesticides in ancient times, substances with similar activities were sought in the practice of herbal processing and insect control and pest control.
For example, when the ancients were controlling pests, they may try various natural products such as plants and minerals. If this compound exists in some natural products, the activity endowed by its structure may play the role of repelling insects and inhibiting the growth of harmful organisms. In terms of drugs, ancient doctors explored the efficacy of drugs, and some substances with special structures were found to have the effect of regulating human functions. If this compound exists in natural medicinal resources, its activity may have an impact on human diseases, and it was included in the scope of drug application by ancient doctors.
Although it is not directly mentioned in Tiangong Kaiwu, clues and shadows related to the potential uses of this compound may be found in the development of ancient practices such as process chemistry, medicine, and agriculture.

1-%5B4-%284-%E6%B0%AF%E8%8B%AF%E5%9F%BA%29-2-%E7%BE%9F%BA%E4%B8%80%E5%9F%BA%5D-1H-%E5%92%AA%E5%94%91 is a complex organic compound with unique chemical properties.
In this compound, the structure of 1- [4- (4-cyanobenzyl) -2-furyl-methyl] -1H-pyrazole endows it with specific reactivity. Cyano (-CN) in cyanobenzyl has high electronegativity, which makes the group easy to participate in nucleophilic substitution reactions. If it reacts with nucleophilic reagents, the cyanyl group can be replaced, thereby changing the molecular structure and properties.
The furanyl part has certain aromaticity and electron cloud distribution characteristics due to the conjugated structure of the furan ring. It can participate in electron transfer related reactions. Under appropriate conditions, the change of electron cloud density on the furan ring can initiate electrophilic substitution reactions, and other functional groups can be introduced at specific positions on the ring.
1H-pyrazole ring contains nitrogen atoms, which are basic and have coordination ability. Lone pair electrons on nitrogen atoms can coordinate with metal ions to form complexes and change the physical and chemical properties of compounds. This property may have applications in the fields of catalysis and materials science. In addition, pyrazole rings can also participate in various organic reactions such as cyclization and addition, expanding the structural diversity of compounds.
In a chemical reaction system, there is a delicate balance between the overall structural stability and reactivity of the compound, and different reaction conditions (temperature, solvent, catalyst) can significantly affect its reaction direction and product selectivity. For example, under mild alkaline conditions, cyano hydrolysis may occur preferentially; while under acidic catalysis and high temperature, ring-opening and other rearrangements of pyrazole or furan rings may occur.

To prepare 1 - [4 - (4 - cyanobenzyl) - 2 - naphthyl - 1 - yl] - 1H - pyrazole, you can follow the following ancient method.
First take an appropriate amount of 4 - bromophenylacetonitrile, place it in a reactor, add potassium carbonate and a phase transfer catalyst, then inject an appropriate amount of N, N - dimethylformamide (DMF) as a solvent, stir well. Slowly drop in 2 - naphthalene formaldehyde, heat it up to a certain temperature, maintain this temperature and stir for several hours. The purpose of this step is to use nucleophilic substitution reaction to condensate 4-bromophenylacetonitrile with 2-naphthalaldehyde to obtain 4- (4-cyanobenzyl) -2-naphthalaldehyde intermediate.
After the reaction is completed, cool the contents in the kettle, quench the reaction with water, and then extract the product with an organic solvent. The organic phases are combined, dried with anhydrous sodium sulfate, filtered and distilled under reduced pressure to remove the solvent to obtain a crude product. The crude product was purified by column chromatography to obtain pure 4- (4-cyanobenzyl) -2-naphthalaldehyde. < Br >
Another appropriate amount of hydrazine hydrate is placed in a reaction flask, ethanol is added as a solvent, and the 4- (4-cyanobenzyl) -2-naphthalaldehyde obtained above is added under stirring. When the reaction number is refluxed at high temperature, this step is to use the condensation reaction of hydrazine and aldehyde to generate a hydrazone intermediate.
After the reaction is completed, the reaction solution is cooled and the ethanol is removed by distillation under reduced pressure. The residue is adjusted to pH value with appropriate amount of acid, precipitated solid, filtered to obtain 1 - [4 - (4 - cyanobenzyl) - 2 - naphthyl - 1 - yl] - 1H - pyrazole crude product. The crude product is recrystallized with appropriate organic solvent to obtain the target product of high purity 1 - [4 - (4 - cyanobenzyl) - 2 - naphthyl - 1 - yl] - 1H - pyrazole. The whole process needs to pay attention to the control of reaction temperature, time, and the ratio of each material to obtain the ideal yield and purity.

I have heard your inquiry, but it is the price of 1- [4- (4-benzyl) -2-naphthyl-methyl] -1H-indole in the market. However, it is not easy to know the details. The market price is often changed due to many reasons.
First, the source flow of materials has a great impact. If the raw materials are easy to obtain and abundant, the price may be flat; if the raw materials are rare and difficult to harvest, the price will be high.
Second, the precision of the craftsmanship is also related to the price. < Br >
Third, the supply and demand of the city is the main reason. If there are many people who want it, and there are few people who supply it, the price will go up; if the supply exceeds the demand, the price will fall.
Fourth, the difference between regions is also different. In prosperous places, there are many merchants and people, frequent transactions, and prices may be different in remote places. < Br >
and 1- [4- (4 -benzyl) -2 -naphthyl-methyl] -1H -indole, or used in various fields, with different uses, different quality requirements and different prices. Therefore, in order to determine its market price, when carefully examining raw materials, craftsmanship, supply and demand, and regional affairs, it is also necessary to consult the industry and observe the market conditions before obtaining a more accurate price.

1 - [4 - (4 - cyanophenyl) - 2 - naphthyl - 1 - yl] - 1H - pyrazole related safety precautions are as follows:
This compound contains a cyanide group, which is highly toxic. It can release cyanide ions in the body, inhibiting cellular respiratory enzymes, causing tissue cells to fail to utilize oxygen, causing tissue hypoxia and poisoning symptoms. When operating, be sure to do it in a well-ventilated place, preferably in a fume hood to prevent inhalation of dust, smoke or vapor containing cyanide compounds. If inhaled inadvertently, it should be immediately transferred to a fresh place in the air and seek medical attention if necessary. < Br >
1 - [4- (4-cyanophenyl) - 2-naphthyl-1-yl] - 1H-pyrazole as an organic compound, some of which may be flammable. Store away from fire and heat sources, and avoid mixing with strong oxidants and other substances that can easily cause combustion and explosion. In the event of a fire, a suitable fire extinguishing agent should be selected according to its chemical properties. Do not blindly use water and other fire extinguishing methods that may increase the danger.
When exposed to this compound, personal protection should be taken. Wear suitable protective gloves to prevent skin contact, because skin contact may lead to the absorption of harmful substances. If inadvertently exposed, rinse immediately with a large amount of flowing water. At the same time, wear protective glasses or masks to prevent compounds from splashing into the eyes. Once splashed, rinse with plenty of water immediately and seek medical attention as soon as possible.
After the operation, thoroughly clean the used equipment to prevent subsequent pollution or danger caused by residual compounds. For the waste generated by the experiment, it needs to be collected in accordance with relevant regulations and handed over to professional institutions for disposal. It cannot be discarded at will to prevent pollution to the environment and potential safety risks.