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What is the chemical structure of 1- {2- [ (7-chloro-1-benzothiophen-3-yl) methoxy] -2- (2,4-dichlorophenyl) ethyl} -1H-imidazole
1-% 7B2-% 5B% 287-chloro-1-benzothiophene-3-yl% 29 methoxy% 5D-2 - (2,4-dichlorophenyl% 29 ethyl% 7D-1H-imidazole, the chemical structure of this compound can be named according to the picture. Looking at its name, 1H-imidazole is the core mother ring, and there is a specific substituent in the first position of imidazole. This substituent is 2 -% 5B% 287 - chloro - 1 - benzothiophene - 3 - yl% 29 methoxy% 5D - 2 - (2,4 - dichlorophenyl% 29 ethyl.
wherein, 2 - (2,4 - dichlorophenyl% 29 ethyl, indicating that there is a monoethyl group, which is connected to 2,4 - dichlorophenyl at 2 - (2,4 - dichlorophenyl% 29 ethyl), that is, the 2 and 4 positions on the benzene ring are replaced by chlorine atoms. And the 2 -% 5B% 287 - chloro - 1 - benzothiophene - 3 - yl% 29 methoxy% 5D part means that at the 2 positions of the above ethyl group, there is also a 7 - chloro - 1 - benzothiophene - 3 - based structure connected by methoxy group. That is, the 7 positions of the 1 - benzothiophene ring are substituted by chlorine atoms, and the 3 positions are connected by methoxy group and ethyl group. In this way, the chemical structure of 1-% 7B2-% 5B% 287-chloro-1-benzothiophene-3-yl% 29-methoxy% 5D-2- (2,4-dichlorophenyl% 29-ethyl% 7D-1H-imidazole was clarified.
What are the main uses of 1- {2- [ (7-chloro-1-benzothiophen-3-yl) methoxy] -2- (2,4-dichlorophenyl) ethyl} -1H-imidazole
1 - {2 - [ (7 - chloro - 1 - benzothiophene - 3 - yl) methoxy] -2 - (2,4 - dichlorophenyl) ethyl} -1H - imidazole, which has a wide range of uses. In the field of medicine, it is often used as a key intermediate in drug synthesis. Its structural characteristics make it unique in the development of new antifungal drugs. It can construct compounds with high antifungal activity through specific chemical reactions, which is of great significance for the treatment of invasive fungal infections and other diseases. In the field of pesticides, it can be modified and modified to create new insecticides or fungicides, which can use their unique chemical structure to poison or inhibit pests or bacteria, improve crop protection efficiency, and ensure agricultural harvest. In the field of materials science, the compound may contribute to the synthesis of materials with special properties due to its special molecular structure, such as the preparation of adsorption materials with high selective adsorption capacity for specific substances, play a role in environmental monitoring and pollutant treatment, and help environmental protection and resource recovery. In conclusion, 1 - {2 - [ (7 - chloro - 1 - benzothiophene - 3 - yl) methoxy] -2 - (2,4 - dichlorophenyl) ethyl} -1H - imidazole has important applications in many fields, and with the deepening of research, more potential uses may be excavated.
What is the synthesis method of 1- {2- [ (7-chloro-1-benzothiophen-3-yl) methoxy] -2- (2,4-dichlorophenyl) ethyl} -1H-imidazole
To prepare 1 - {2 - [ (7 - chloro - 1 - benzothiophene - 3 - yl) methoxy] - 2 - (2,4 - dichlorophenyl) ethyl} - 1H - imidazole, the method is as follows:
First take 7 - chloro - 1 - benzothiophene - 3 - methanol, place it in a clean reaction bottle, dissolve it with an appropriate amount of organic solvent, such as dichloromethane. In this solution, slowly add an appropriate base, such as potassium carbonate, stir well, so that the base is fully dissolved and dispersed. Then 2 - (2,4 - dichlorophenyl) ethyl halide containing haloalkane is slowly dropped into the reaction flask to control the dripping speed and do not overdo the reaction. After the drip addition is completed, heat up to an appropriate temperature and keep stirring to continue the reaction. This step aims to form a connection between (7 - chloro - 1 - benzothiophene - 3 - yl) methoxy and 2 - (2,4 - dichlorophenyl) ethyl by nucleophilic substitution reaction.
After the first step of reaction is completed, the reaction mixture is processed. The organic phase is extracted and separated with water and an organic solvent, and the organic phase is collected. Then the organic phase is dried with a desiccant such as anhydrous sodium sulfate to remove the moisture. After that, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
Transfer this crude product to another reaction flask, add imidazole and an appropriate amount of catalyst, such as a combination of cuprous iodide and ligands, and then add a suitable base, such as potassium tert-butoxide. Replace the air in the reaction flask with nitrogen to form an inert atmosphere to avoid side reactions. Warm to a certain temperature and stir continuously to react imidazole with the previously obtained product to form the target product 1 - {2 - [ (7 - chloro - 1 - benzothiophene - 3 - yl) methoxy] - 2 - (2,4 - dichlorophenyl) ethyl} - 1H - imidazole.
After the reaction is completed, the reaction solution is cooled to room temperature, and the product is purified by column chromatography. The fractions containing the target product are collected, and impurities are removed. Finally, pure 1 - {2- [ (7-chloro-1-benzothiophene-3-yl) methoxy] -2 - (2,4-dichlorophenyl) ethyl} -1H -imidazole can be obtained. Each step of the reaction requires strict control of the reaction conditions, such as temperature, reagent dosage, reaction time, etc., to improve the yield and purity of the product.
What are the physical properties of 1- {2- [ (7-chloro-1-benzothiophen-3-yl) methoxy] -2- (2,4-dichlorophenyl) ethyl} -1H-imidazole
1 - {2 - [ (7 - chloro - 1 - benzothiophene - 3 - yl) methoxy] - 2 - (2,4 - dichlorophenyl) ethyl} - 1H - imidazole This substance has multiple physical properties. Its form may be solid, stable at room temperature. Looking at its appearance, it may be in the shape of a white to off-white powder, fine and uniform, which is convenient for subsequent processing and application.
When it comes to solubility, this substance behaves differently in organic solvents. In some polar organic solvents such as ethanol and acetone, it can exhibit a certain solubility, and gradually disperse and dissolve by intermolecular forces interacting with solvents. However, in water, its solubility is not good. Due to the molecular structure characteristics, it is difficult to form an effective force with water molecules, and it mostly exists in a suspended state.
Melting point is also one of the important physical properties. Experiments have determined that its melting point is in a specific temperature range. At this temperature, the substance transitions from a solid state to a liquid state, and the arrangement of molecules changes significantly. The exact value of the melting point is of great significance to its use and storage under different conditions, and is related to the stability of its physical form.
In addition, density is also a physical property that cannot be ignored. The substance has a specific density, reflecting its mass per unit volume. The characteristics of density, which affect its distribution and related operations in the mixed system, are important factors to consider when it comes to separation, mixing and other processes.
The above many physical properties together constitute the physical properties of 1 - {2- [ (7-chloro-1-benzothiophene-3-yl) methoxy] -2 - (2,4-dichlorophenyl) ethyl} -1H -imidazole, providing the basis for its application in various fields.
What is the market outlook for 1- {2- [ (7-chloro-1-benzothiophen-3-yl) methoxy] -2- (2,4-dichlorophenyl) ethyl} -1H-imidazole?
1-% {2- [ (7-chloro-1-benzothiophene-3-yl) methoxy] 2- (2,4-dichlorophenyl) ethyl} -1H-imidazole, this is a rather complex organic compound. Looking at its market prospects, we need to explore it many times.
From the perspective of the pharmaceutical field, such compounds may have unique pharmacological activities. Today, there is a strong demand for new compounds in pharmaceutical research and development to overcome various intractable diseases. If this compound is confirmed to have significant therapeutic effects, such as antibacterial, antiviral or anti-tumor, through rigorous experiments and research, it will have broad prospects in the pharmaceutical market. Many pharmaceutical companies will also compete to invest resources and carry out in-depth research and development to transform them into clinically usable drugs.
However, in the chemical industry, its prospects depend on the difficulty and cost of the synthesis process. If the synthesis process is simple and cost-controllable, it may be mass-produced and used as a key intermediate for the synthesis of other fine chemicals, thus expanding its application scope in the chemical industry chain. However, if the synthesis process is complicated and costly, or restricts its large-scale industrial production, it is only suitable for the preparation of specific high-end chemical products.
Furthermore, environmental regulations are increasingly stringent, and the environmental friendliness of compounds is also a key consideration. If it has little impact on the environment during production, use and disposal, it will be more favored by the market. On the contrary, if it is potentially harmful to the environment, it may require a large amount of resources to solve environmental protection problems, or reduce its market competitiveness.
In summary, the market prospect of 1-% {2- [ (7-chloro-1-benzothiophene-3-yl) methoxy] -2- (2,4-dichlorophenyl) ethyl} -1H-imidazole depends on many factors such as pharmaceutical research and development results, chemical synthesis costs and environmental protection characteristics. It is difficult to make a conclusion. Only through in-depth research and practice can the exact market trend be clarified.