1,1'-sulfonylbis(1H-imidazole)

1% 2C1% 27 - sulfonylbis% 281H - imidazole% 29, Chinese name 1,1 '-sulfonyldiimidazole, this substance is widely used. In the field of organic synthesis, it can be called an important reagent. Due to its special structure, it can be used as an activator to assist the reaction between carboxylic acids, alcohols and other compounds, making the reaction easier to occur. For example, in the preparation of ester compounds, 1,1' -sulfonyldiimidazole can activate carboxylic acids to react efficiently with alcohols to obtain ideal yields.
In the field of medicinal chemistry, it also plays a key role. In drug development, it is often necessary to modify the structure of lead compounds. 1,1 '-sulfonyl diimidazole can participate in it to build specific functional groups and optimize the properties of drug molecules, such as improving the solubility, stability and biological activity of drugs, etc., laying the foundation for creating better drugs.
In materials science, it can be used in the synthesis of polymer materials. By participating in polymerization reactions, changing the structure and properties of polymers, materials with special properties, such as polymer materials with good mechanical properties or special optical properties, can be prepared to meet the needs of different fields. In short, 1,1' -sulfonyl diimidazole plays an indispensable role in many scientific fields, promoting the development and progress of various fields.

1% 2C1% 27 - sulfonylbis% 281H - imidazole% 29 is 1,1 '-sulfonylbis (1H - imidazole). The physical properties of this substance are particularly important for its application in many fields.
Looking at its appearance, under normal circumstances, 1,1' -sulfonylbis (1H - imidazole) is mostly white to light yellow crystalline powder. This color characteristic can be the primary basis for preliminary identification and quality determination. Its texture is fine and the particles are uniform, which facilitates uniform dispersion in various preparations and reaction systems, thus ensuring the uniformity of the reaction or application.
When it comes to solubility, 1,1 '-sulfonyl bis (1H-imidazole) is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, with a little stirring, it can be seen to slowly dissolve to form a clear solution. This solubility is conducive to its use as a reactant or catalyst carrier in organic synthesis reactions, so that the reaction can be carried out efficiently in homogeneous systems. However, its solubility in water is relatively limited, and this point needs to be carefully considered when it comes to the application of aqueous systems.
Once again, the melting point of 1,1' -sulfonyl bis (1H-imidazole) has a specific melting point range, which is between about 180 and 185 ° C. Melting point is the inherent physical constant of a substance. Accurate determination of melting point can not only be used to identify its purity, but also to evaluate its stability under heating process or high temperature reaction conditions, which is of great significance. When heated to the vicinity of the melting point, the substance gradually changes from a solid state to a liquid state. This phase transition process needs to be precisely controlled so as not to affect the quality of the subsequent product or the reaction process.
As for the density, although there is no extremely accurate and widely reported data, it can be roughly inferred that its density is moderate. The moderate density makes it not easy to fly and lose due to low density during storage, transportation and actual operation, nor will it cause inconvenience in packaging and handling due to excessive density.
In addition, 1,1 '-sulfonyl bis (1H-imidazole) is relatively stable chemically at room temperature and pressure, but its structure may change under extreme conditions such as strong acid, strong base or high temperature. This stability is related to physical properties and jointly determines its scope of application and storage conditions.

1% 2C1% 27-sulfonyl bis (1H-imidazole), this is an organic compound. The stability of its chemical properties needs to be viewed from multiple perspectives.
Let's talk about its structure first, the sulfonyl group is connected to the imidazole group. Imidazole has an aromatic heterocyclic structure, electron-rich properties, and has certain stability. The sulfur atom in the sulfonyl group is connected to two oxygen atoms in a strong electron-absorbing state. This structure is connected, which has a unique effect on the stability of the compound.
From the perspective of reactivity, the nitrogen atom on the imidazole ring has a lone pair of electrons, which can be used as a nucleophilic check point and is easy to react with electrophilic reagents. However, the electron-absorbing effect of the sulfonyl group may reduce the electron cloud density of the imidazole ring, which may change the nucleophilic reactivity. If there are electrophilic reagents in the environment, under suitable conditions, reactions may occur, so its stability is not absolute.
Besides thermal stability, compounds usually containing aromatic rings have certain thermal stability due to the existence of conjugated systems. However, the sulfonyl groups in this compound may have other effects on thermal stability. When the sulfur-oxygen bond in the sulfonyl group is heated, it may break due to energy changes, which in turn affects the overall stability. When the temperature rises to a certain level, the sulfur-oxygen bond breaks, causing molecular structure changes, which shows that its thermal stability is also limited.
In common chemical environments, if there are no special reagents and conditions, the compound can remain relatively stable for a certain period of time. However, in case of special chemicals such as strong acids, strong bases or strong oxidizing agents, due to the reactivity, stability or impact of imidazole ring and sulfonyl group in the structure, the molecular structure may change.
In short, the stability of the chemical properties of 1% 2C1% 27-sulfonyl bis (1H-imidazole) is not static, but is influenced by various factors such as structure, chemical substances and conditions in the environment.

To prepare 1% 2C1% 27 - sulfonylbis% 281H - imidazole% 29, the following method is often followed. In the past, imidazole and sulfonyl chloride were mostly used as starting materials, and the two were intersected in a suitable reaction environment.
Prepare the refined imidazole first to ensure its high purity, which is the basis for a smooth reaction. Take an equal or slightly excessive amount of sulfonyl chloride to prevent imidazole from not fully responding. Place the two in an organic solvent, such as dichloromethane, chloroform, etc. These solvents have good solubility to the reactants and are stable in nature and do not disturb the reaction.
When reacting, it is appropriate to control the temperature in an ice bath to room temperature. At the beginning, the cold of the ice bath can make the reaction start smoothly, so as not to overreact and cause side reactions to clump. When the reaction starts slightly, it gradually rises to room temperature, which promotes the reaction to accelerate. In the reaction system, acid binding agents, such as triethylamine and pyridine, are often used, which can trap the acid generated by the reaction and keep the reaction moving forward.
When the reaction occurs, it is often monitored by thin-layer chromatography (TLC). When the raw material point is eliminated, the product point is obvious and stable, indicating that the reaction is nearly complete. Afterwards, conventional separation and purification techniques, such as column chromatography, are used to separate the product and impurities according to the difference in retention between the stationary phase and the mobile phase. The product-rich fractions were collected and then distilled under reduced pressure and recrystallized to remove residual impurities to obtain a high purity of 1% 2C1% 27 - sulfonylbis% 281H - imidazole% 29.

1% 2C1% 27 - sulfonylbis% 281H - imidazole% 29, which is a chemical, or 1,1 '-sulfonylbis (1H - imidazole) in Chinese. However, in the market, its price range is difficult to determine. The price is often determined by many factors, such as quality, supply and demand, place of manufacture and sale, amount of purchase, season changes, etc.
If the quality is good and meets high-end demand, the price may be high; conversely, if the quality is average, the price may be slightly lower. When the market is urgent and supply is scarce, the price also rises; if supply exceeds demand, the price decreases. If you buy it near the place of origin, or because you save long-distance freight, the price is favorable; if you buy it in different places, the price may increase. Bulk buyers often get discounts due to large quantities, and the unit price is lower; if you buy a small amount, the price may be higher. And the chemical market often fluctuates with the seasons, and the price of raw materials changes and energy consumption differences in some periods cause its price to fluctuate.
To sum up, if you want to know the exact price range, you need to consult the supplier of chemical raw materials in detail, and get an accurate quotation according to the quality and quantity you need. It must not be based on conventional speculation alone, but must be negotiated through business to get the real price.