1,1'-Oxalyldiimidazole

1% 2C1% 27 - Oxalyldiimidazole (1,1 '-oxalyldiimidazole) is a commonly used reagent for organic synthesis. Its main uses involve a wide range of chemical synthesis reactions.
Bearing the brunt, in the field of peptide synthesis, 1,1' -oxalyldiimidazole can be used as a condensation agent. When synthesizing polypeptides, the carboxyl group of amino acids needs to be connected to the amino group, and this reagent can activate the carboxyl group, making it easier to react with the amino group and efficiently promote the formation of peptide bonds. Its function is to promote the reaction in the direction of generating polypeptides, improve the reaction efficiency and yield, and assist chemists in synthesizing various polypeptides of specific sequences.
Furthermore, in the field of medicinal chemistry, 1,1 '-oxalydiimidazole also has key uses. In the process of drug development, complex molecular structures are often required. This reagent can participate in many reaction steps, such as modifying and linking specific functional groups, and assisting in the synthesis of drug molecules with specific pharmacological activities. Through its participation in the reaction, chemists can precisely regulate the structure and properties of molecules to meet the requirements of drug development on molecular activity, selectivity and stability.
In addition, in other aspects of organic synthetic chemistry, 1,1' -oxalydiimidazole can also be used to construct heterocyclic compounds. Heterocyclic compounds play an important role in the fields of organic synthesis and materials science. By ingeniously designing the reaction path and taking advantage of the unique reactivity of 1,1 '-oxalyl diimidazole, the efficient construction of heterocyclic structures can be achieved, laying the foundation for the synthesis of new organic materials and functional molecules.
In short, 1,1' -oxalyl diimidazole is an indispensable reagent in many fields of peptide synthesis, pharmaceutical chemistry and organic synthesis due to its unique chemical properties, assisting chemists in the synthesis and construction of various complex organic molecules.

1%2C1%27-Oxalyldiimidazole is 1,1 '-oxalyl diimidazole, and the physical properties are as follows:
It is a white to off-white crystalline powder, which is pure and free of variegation. Stable at room temperature and pressure, it can cause danger when encountering hot topics, open flames, and strong oxidants, and should be avoided. The melting point is about 116-118 ° C. At this temperature, the substance gradually melts from solid to liquid, which is an important physical characteristic.
Solubility, easily soluble in common organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., but poor solubility in water. This property makes it convenient to select suitable solvents to build reaction systems in organic synthesis reactions.
1,1 '-oxalyl diimidazole has high chemical activity, and the imidazole group in the molecule cooperates with oxalyl group, so that it can efficiently participate in a variety of organic reactions. It is often used as an activator and contributes greatly to peptide synthesis, ester synthesis and other fields, which can speed up the reaction process and improve the yield of products. However, due to its high activity, it needs to be properly sealed when stored, and placed in a cool and dry place to prevent deterioration caused by air and moisture.

The chemical synthesis of 1% 2C1% 27-oxalyldiimidazole (1,1 '-Oxalyldiimidazole) is a very important topic in the field of organic synthesis. The most common method of synthesis is oxalyl chloride and imidazole as starting materials, obtained by condensation reaction.
First take an appropriate amount of oxalyl chloride and place it in a suitable reaction vessel. The container should be clean and dry to prevent impurities from interfering with the reaction. Next, under the condition of low temperature and stirring, slowly add the solution of imidazole dropwise. When adding dropwise, pay attention to control the temperature of the reaction, generally maintain it in the low temperature range to prevent side reactions from occurring.
After the dropwise addition is completed, continue to stir the reaction for a period of time to fully react the reactants. In this process, the temperature of the reaction system, stirring speed and other factors have an important impact on the progress of the reaction and the purity of the product. After the reaction, post-processing operations such as extraction, washing, drying, column chromatography, etc. are often required to purify the product.
During extraction, a suitable organic solvent is selected to extract the product from the reaction mixture. The washing step is designed to remove impurities and ensure the purity of the product. The drying process removes the moisture contained in the product, while column chromatography is further separated and purified to obtain a high purity of 1,1 '-oxalyl diimidazole. In this way, through this series of steps, the target product can be obtained.

1% 2C1% 27 - Oxalyldiimidazole (1,1 '-oxalyldiimidazole) is a commonly used reagent in organic synthesis. When using it, many matters need to be paid attention to.
First, safety comes first. This reagent is toxic and irritating to a certain extent. During operation, it must be well protected. Wear laboratory clothes, gloves and goggles to avoid contact with the skin and eyes of the reagent. In case of accidental contact, rinse with plenty of water immediately and seek medical attention according to specific conditions.
Second, its chemical properties need to be understood in detail. 1,1' -oxalyldiimidazole has high activity, is easy to hydrolyze in contact with water, and has poor stability in humid air. Therefore, when storing, it needs to be placed in a dry place, and after taking it, it should be sealed in time to prevent deterioration.
Third, the reaction conditions should be precisely controlled. In the reactions involved, factors such as temperature, solvent, and the proportion of reactants have a great impact on the reaction process and product yield. For example, some reactions need to be started at low temperature and then slowly warmed up; different solvents also have different effects on the reaction rate and selectivity. Before the reaction, you should study the relevant literature in detail to explore the appropriate conditions.
Fourth, post-treatment should not be ignored. After the reaction, when separating and purifying the product, in view of the characteristics of the reagents and their reaction by-products, choose an appropriate method. For example, by taking advantage of the difference in solubility, extract and recrystallize to obtain pure products.
In conclusion, the use of 1,1 '-oxalyl diimidazole requires careful treatment in terms of safety, properties, reaction conditions, post-treatment, etc., in order to ensure the smooth operation of the experiment and achieve the intended purpose.

I look at you and ask about the market price range of 1,1 '-oxalyl diimidazole. This is also a question about the market situation. However, the market situation is changeable, and prices are unstable. They are influenced by many reasons, such as the situation of supply and demand, the distance of origin, the quality of the goods, and the difference of the times.
In the past, due to the abundance of raw materials and the clumsiness of the craftsmanship, the price also fluctuated. When supply and demand are flat, the price may be in a certain area, but if the demand exceeds the supply, the price will rise; if the supply exceeds the demand, the price may fall.
The distance of the origin is related to the freight, and the cost will be high if it is far away, and the price will also increase accordingly; if the cost is saved recently, the price may be slightly reduced The difference in quality is particularly critical. The price of the excellent product is high, and the price of the second is low.
And the times change, the regulation of politics, and the competition of business can all make the price fluctuate. Therefore, in order to determine the range of the current price, when visiting the cities and observing the business information, it is difficult to determine the range of the price.